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Publication date Communities Collections Article title Author(s) Journal/Conference
29 Nov 2024 BMRC Singapore Immunology Network Development of BCMA-Targeted Bispecific Natural Killer Cell Engagers for Multiple Myeloma Treatment Minchuan Zhang, Han Ping Loh, Shiyi Goh Fang, Yuansheng Yang, Kong-Peng Lam, Shengli Xu Antibodies
18 Oct 2024 BMRC Bioprocessing Technology Institute Thermal and pH stress dictate distinct mechanisms of monoclonal antibody aggregation Kong Meng Hoi, Kuin Tian Pang, Corrine Wan, Zi Ying Zheng, Beiying Qiu, Yuansheng Yang, Zhang Wei, Ying Swan Ho, Ian Walsh, Sean Chia International Journal of Biological Macromolecules
22 Jul 2024 BMRC Bioprocessing Technology Institute Effects of molecule hydrophobicity and structural flexibility of appended bispecific antibody on Protein A chromatography Xinhui Wang, Nattha Ingavat, Jia Min Liew, Nuruljannah Dzulkiflie, Han Ping Loh, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang, Wei Zhang Journal of Chromatography A
13 Dec 2023 BMRC Bioprocessing Technology Institute Harnessing ceramic hydroxyapatite as an effective polishing strategy to remove product- and process-related impurities in bispecific antibody purification Nattha Ingavat, Xinhui Wang, Jia Min Liew, Farouq Bin Mahfut, Ka Pui But, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang, Kobayashi Shintaro, Maria Tsoumpra, Wei Zhang Bioresources and Bioprocessing
20 Sep 2023 BMRC Bioprocessing Technology Institute Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform Ngan T. B. Nguyen, Hau Wan Leung, Kuin Tian Pang, Shi Jie Tay, Ian Walsh, Andre B. H. Choo, Yuansheng Yang Scientific Reports
5 Jul 2023 BMRC Bioprocessing Technology Institute Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang mAbs
22 Apr 2023 BMRC Bioprocessing Technology Institute Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content Sean Chia, Shi Jie Tay, Zhiwei Song, Yuansheng Yang, Ian Walsh, Kuin Tian Pang Biomedicine & Pharmacotherapy
25 Jan 2023 BMRC Bioprocessing Technology Institute Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step Serene W. Chen, Zi Ying Zheng, Farouq Bin Mahfut, Yuansheng Yang, Masahiro Ogino, Kazuo Okada, Kohei Sato, Wei Zhang PLOS ONE
4 Jul 2022 BMRC Bioprocessing Technology Institute Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography Serene W. Chen, Kong Meng Hoi, Farouq Bin Mahfut, Yuansheng Yang, Wei Zhang Bioresources and Bioprocessing
9 Jun 2022 BMRC Singapore Immunology Network Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for the suppression of multiple myeloma cell growth Jianxin Huo, Yuhan Huang, Ziying Zheng, Xin Ni Tay, Farouq Bin Mahfut, Wei Zhang, Kong-Peng Lam, Yuansheng Yang, Shengli Xu Antibody Therapeutics