Singapore Immunology Network

Publication date Article title Author(s)
7 May 2021 Microscopy-based Methods for Rosetting Assay in Malaria Research Wenn-Chyau Lee, Laurent Renia
23 Dec 2020 Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors Claudia Pasqualini, Tatsuya Kozaki, Marco Bruschi, Thi Hai Hoa Nguyen, Véronique Minard-Colin, David Castel, Jacques Grill, Florent Ginhoux
1 Jul 2020 Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor Immanuel Kwok, Etienne Becht, Yu Xia, Melissa Ng, Ye Chean Teh, Leonard De Li Tan, Maximilien Evrard, Jackson L.Y Li, Hoa Tran TN, Yingrou Tan, Dehua Liu, Kahang Liong, Keith Leong, Yuning Zhang, Andre Olsson, Chinmay Kumar Mantri, Pavithra Shyamsunder, Zhaoyuan Liu, Cecile Piot, Charles-Antoine Dutertre, Hui Cheng, Sudipto Bari, Nicholas Ang, Subhra K. Biswas, H. Philip Koeffler, Hong Liang Tey, Anis Larbi, I-Hsin Su, Bernett Lee, Ashley St. John, Jerry K.Y. Chan, William Y.K. Hwang, Jinmiao Chen, Nathan Salomonis, Shu Zhen Chong, H. Leighton Grimes, Bing Liu, Andrés Hidalgo, Evan W. Newell, Tao Cheng, Florent Ginhoux, Lai Guan Ng
10 Jun 2020 The Role of Single-Cell Technology in the Study and Control of Infectious Diseases Weikang Nicholas Lin, Matthew Zirui Tay, Ri Lu, Yi Liu, Chia-Hung Chen, Lih Feng Cheow
1 Jun 2020 Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients Chek Meng Poh, Guillaume Carissimo, Bei Wang, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Wen-Hsin Lee, Anthony Torres-Ruesta, Yee-Sin Leo, Mark I-Cheng Chen, Seow-Yen Tan, Barnaby Edward Young, David C. Lye, Brendon John Hanson, Cheng-I Wang, Laurent Renia, Lisa F. P. Ng
20 May 2020 Deciphering human macrophage development at single-cell resolution Chunli Ma, Lei Cui, Rui Zhang, K. Y. Jerry Chan, Jian He, Jie Zhou, Xianlong Li, Zongcheng Li, Yanli Ni, Zhilei Bian, Yandong Gong, Tao Huang, Z. W. Christopher Lee, Lihong Bian, Zhijie Bai, Hui Shi, Yang Zeng, Chen Liu, Lai Guan Ng, Florent Ginhoux, Bing Liu
18 Feb 2020 Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis Wenn-Chyau Lee, Bruce Russell, Radoslaw Mikolaj Sobota, Khairunnisa Ghaffar, Shanshan W Howland, Zi Xin Wong, Alexander G. Maier, Dominique Dorin-Semblat, Subhra Biswas, Benoit Gamain, Yee-Ling Lau, Benoit Malleret, Cindy Chu, François Nosten, Laurent Renia
27 Jan 2020 IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease Lauretta D. Low, Liangjian Lu, Chang-Yien Chan, Jinmiao Chen, Henry H. Yang, Hanry Yu, Caroline G. L. Lee, Kar-Hui Ng, Hui-Kim Yap
9 Dec 2019 Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells. Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Ohno-Oishi, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi
6 Dec 2019 Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy Alfonso Tan-Garcia, Fritz Lai, Joe Poh Sheng Yeong, Sergio E. Irac, Pei Y. Ng, Rasha Msallam, Jeffrey Chun Tatt Lim, Lu-En Wai, Christine Y. L. Tham, Su P. Choo, Tony Lim, Dan Y. Young, Roberta D’Ambrosio, Elisabetta Degasperi, Riccardo Perbellini, Evan Newell, Nina Le Bert, Florent Ginhoux, Antonio Bertoletti, Qingfeng Chen, Charles-Antoine Dutertre
5 Nov 2019 Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women Fok-Moon Lum, Vipin Narang, Susan Hue, Jie Chen, Naomi McGovern, Ravisankar Rajarethinam, Jeslin J. L. Tan, Siti Naqiah Amrun, Yi-Hao Chan, Cheryl Y. P. Lee, Tze-Kwang Chua, Wearn-Xin Yee, Nicholas K. W. Yeo, Thiam-Chye Tan, Xuan Liu, Sam Haldenby, Yee-Sin Leo, Florent Ginhoux, Jerry K. Y. Chan, Julian Hiscox, Chia-Yin Chong, Lisa F. P. Ng
5 Sep 2019 Fate mapping via Ms4a3 expression history traces monocyte-derived cells Zhaoyuan Liu, Yaqi Gu, Svetoslav Chakarov, Camille Bleriot, Immanuel Kwok, Xin Chen, Amanda Shin, Weijie Huang, Regine J. Dress, Charles-Antoine Dutertre, Andreas Schlitzer, Jinmiao Chen, Lai Guan Ng, Honglin Wang, Zhiduo Liu, Bing Su, Florent Ginhoux
29 Aug 2019 Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells Charles-Antoine Dutertre, Etienne Becht, Sergio Erdal Irac, Ahad Khalilnezhad, Vipin Narang, Shabnam Khalilnezhad, Pei Y. Ng, Lucas L. van den Hoogen, Jing Yao Leong, Bernett Lee, Marion Chevrier, Xiao Meng Zhang, Pearly Ai Yong Jean, Geraldine Koh, Josephine Lum, Shanshan Howland Wu, Esther Mok, Jinmiao Chen, Anis Larbi, Henry Kun Kiaang Tan, Tony Kiat Hon Lim, Panagiota Karagianni, Athanasios G. Tzioufas, Benoit Malleret, Joshua Brody, Salvatore Albani, Joel van Roon, Timothy Radstake, Evan W. Newell, Florent Ginhoux
30 Jul 2019 Biphasic impact of prenatal inflammation and macrophages depletion on the wiring of neocortical inhibitory circuits Morgane Sonia Thion, Coralie-Anne Mosser, Isabelle Fe´re´ zou, Pauline Grisel, Sofia Baptista, Donovan Low, Florent Ginhoux, Sonia Garel, Etienne Audinat
26 Jul 2019 CSF-1 controls cerebellar microglia and is required for motor function and social interaction Veronika Kana, Fiona A. Desland, Maria Casanova-Acebes, Pinar Ayata, Ana Badimon, Elisa Nabel, Kazuhiko Yamamuro, Marjolein Sneeboer, I-Li Tan, Meghan E. Flanigan, Samuel A. Rose, Christie Chang, Andrew Leader, Hortense Le Bourhis, Eric S. Sweet, Navpreet Tung, Aleksandra Wroblewska, Yonit Lavin, Peter See, Alessia Baccarini, Florent Ginhoux, Violeta Chitu, E. Richard Stanley, Scott J. Russo, Zhenyu Yue, Brian D. Brown, Alexandra L. Joyner, Lotje D. De Witte, Hirofumi Morishita, Anne Schaefer, Miriam Merad
20 Jul 2019 Plasmacytoid dendritic cells develop from Ly6D + lymphoid progenitors distinct from the myeloid lineage Regine J Dress, Charles-Antoine Dutertre, Amir Giladi, Andreas Schlitzer, Ivy Low, Nurhidaya Binte Shadan, Alicia Tay, Josephine Lum, Muhammad Faris Bin Mohd Kairi, Yi Hwang You, Etienne Becht, Cheng Yang, Marion Chevrier, Anis Larbi, Evan W Newell, Ido Amit, Jinmiao Chen, Florent Ginhoux
1 Jul 2019 Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen Kohei Fujita, Svetoslav Chakarov, Tetsuro Kobayashi, Keiko Sakamoto, Benjamin Voisin, Kaibo Duan, Taneaki Nakagawa, Keisuke Horiuchi, Masayuki Amagai, Florent Ginhoux, Keisuke Nagao
27 Jun 2019 Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm Wenn-Chyau Lee, Bruce Russell, Laurent Renia
17 Jun 2019 Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome Keiichi Ishihara, Ryohei Shimizu, Kazuyuki Takata, Eri Kawashita, Kenji Amano, Atsushi Shimohata, Donovan Low, Takeshi Nabe, Haruhiko Sago, Warren S. Alexander, Florent Ginhoux, Kazuhiro Yamakawa, Satoshi Akiba
30 Apr 2019 Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate Beomsue Kim, Masahiro Fukuda, Jung‐Yeol Lee, Dongdong Su, Srikanta Sanu, Aymeric Silvin, Audrey T. T. Khoo, Taejoon Kwon, Xiao Liu, Weijie Chi, Xiaogang Liu, Sejong Choi, Diana S. Y. Wan, Sung‐Jin Park, Jin‐Soo Kim, Florent Ginhoux, H. Shawn Je, Young‐Tae Chang
15 Mar 2019 Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Svetoslav Chakarov, Hwee Ying Lim, Leonard Tan, Sheau Yng Lim, Peter See, Josephine Lum, Xiao-Meng Zhang, Shihui Foo, Satoshi Nakamizo, Kaibo Duan, Wan Ting Kong, Rebecca Gentek, Akhila Balachander, Daniel Carbajo, Camille Bleriot, Benoit Malleret, John Kit Chung Tam, Sonia Baig, Muhammad Shabeer, Sue-Anne Ee Shiow Toh, Andreas Schlitzer, Anis Larbi, Thomas Marichal, Bernard Malissen, Jinmiao Chen, Michael Poidinger, Kenji Kabashima, Marc Bajénoff, Lai Guan Ng, Véronique Angeli, Florent Ginhoux
5 Mar 2019 Microglial Functionality Varies by Niche in Retinal Homeostasis and Degeneration Emily G. O’Koren, Chen Yu, Mikael Klingeborn, Alicia Y. W. Wong, Cameron L. Prigge, Rose Mathew, Joan Kalnitsky, Rasha A. Msallam, Aymeric Silvin, Jeremy N. Kay, Catherine Bowes Rickman, Vadim Y. Arshavsky, Florent Ginhoux, Miriam Merad, Daniel R. Saban
5 Mar 2019 HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers Hui Ling Ko, Ziyi Zhuo, Ee Chee Ren
22 Feb 2019 Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21 Patricia M. L. Ng, Nivashini Kaliaperumal, Chia Yin Lee, Wen Jie Chin, Hwee Ching Tan, Veonice B. Au, Angeline X. -H. Goh, Qiao Wen Tan, Darren S. G. Yeo, John E. Connolly, Cheng-I Wang
15 Jan 2019 MeSsAGe Risk Score: Tool for Renal Biopsy Decision in Steroid-dependent Nephrotic Syndrome Chang-Yien Chan, Lourdes Paula Resontoc, Md Abdul Qader, Yiong-Huak Chan, Isaac Desheng Liu, Perry Yew-Weng Lau, Mya Than, Wee-Song Yeo, Alwin Hwai-Liang Loh, Puay-Hoon Tan, Changli Wei, Jochen Reiser, Subhra K Biswas, Kar-Hui Ng, Hui-Kim Yap
8 Nov 2018 Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult Rebecca Gentek, Clément Ghigo, Guillaume Hoeffel, Audrey Jorquera, Rasha Msallam, Stephan Wienert, Frederick Klauschen, Florent Ginhoux, Marc Bajénoff
12 Oct 2018 Microglia and early brain development: an intimate journey Morgane S. Thion, Florent Ginhoux, Sonia Garel
24 Jul 2018 LYVE-1+ macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen Hwee Ying Lim, Sheau Yng Lim, Chek Kun Tan, Chung Hwee Thiam, Chi Ching Goh, Daniel Carbajo, Samantha Hui Shang Chew, Peter See, Svetoslav Chakarov, Xiao Nong Wang, Li Hui Lim, Louise A. Johnson, Josephine Lum, Chui Yee Fong, Ariff Bongso, Arijit Biswas, Chern Goh, Maximilien Evrard, Kim Pin Yeo, Ranu Basu, Jun Kit Wang, Yingrou Tan, Rohit Jain, Shweta Tikoo, Cleo Choong, Wolfgang Weninger, Michael Poidinger, Richard E. Stanley, Matthew Collin, Nguan Soon Tan, Lai Guan Ng, David G. Jackson, Florent Ginhoux, Ve´ronique Angeli
17 Nov 2017 Enterococcus faecalis promotes innate immune suppression and polymicrobial catheter-associated urinary tract infection Hwee Mian Sharon Goh, Kelvin Kian Long Chong, Soumili Bhaduri-Tagore, Sarah Holec, Regine Dress, Florent Ginhoux, Molly A. Ingersoll, Rohan B. H. Williams, Kimberly A. Kline, Brenda Yin Qi Tien
17 Oct 2017 Enterococcus faecalis modulates immune activation and slows healing during wound infection Kelvin Kian Long Chong, Wei Hong Tay, Baptiste Janela, Adeline Mei Hui Yong, Tze Horng Liew, Leigh Madden, Damien Keogh
5 Sep 2017 Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter Hui Ling Ko, Tze Hau Lam, Huijin Ng, Jiaying Toh, Liang Wei Wang, Ee Chee Ren
18 Jul 2017 Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Tatsuya Kozaki, Kazuyuki Takata, Christopher Zhe Wei Lee, Morgane Sonia Thion, Masayuki Otsuka, Shawn Lim, Kagistia Hana Utami, Kerem Fidan, Dong Shin Park, Benoit Malleret, Svetoslav Chakarov, Peter See, Donovan Low, Gillian Low, Marta Garcia-Miralles, Ruizhu Zeng, Jinqiu Zhang, Chi Ching Goh, Ahmet Gul, Sandra Hubert, Bernett Lee, Jinmiao Chen, Ivy Low, Nurhidaya Binte Shadan, Josephine Lum, Tay Seok Wei, Esther Mok, Shohei Kawanishi, Yoshihisa Kitamura, Anis Larbi, Michael Poidinger, Laurent Renia, Lai Guan Ng, Yochai Wolf, Steffen Jung, Tamer O¨ nder, Evan Newell, Tara Huber, Eishi Ashihara, Sonia Garel, Mahmoud A. Pouladi, Florent Ginhoux
28 Jan 2016 The mononuclear phagocyte system in organ transplantation J. Ochando, W.-H. Kwan, F. Ginhoux, J. A. Hutchinson, D. Hashimoto, M. Collin
17 Dec 2015 New insights into the multidimensional concept of macrophage ontogeny, activation and function Florent Ginhoux, Joachim L Schultze, Peter J Murray, Jordi Ochando, Subhra K Biswas
25 Nov 2015 Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors Franziska Paul, Ya’ara Arkin, Amir Giladi, Diego Adhemar Jaitin, Ephraim Kenigsberg, Hadas Keren-Shaul, Deborah Winter, David Lara-Astiaso, Meital Gury, Assaf Weiner, Eyal David, Nadav Cohen, Felicia Kathrine Bratt Lauridsen, Simon Haas, Andreas Schlitzer, Alexander Mildner, Florent Ginhoux, Steffen Jung, Andreas Trumpp, Bo Torben Porse, Amos Tanay, Ido Amit
2 Oct 2015 Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems Ari Waisman, Florent Ginhoux, Melanie Greter, Julia Bruttger
22 Sep 2015 Ontogeny of tissue-resident macrophages Guillaume Hoeffel, Florent Ginhoux
30 Jul 2015 Identification of a novel lymphoid population in the murine epidermis Guillaume Hoeffel, Francisca F. Almeida, Peter See, Lai Guan Ng, Hans Jörg Fehling, Nicholas R. J. Gascoigne, Ichiro Taniuchi, Florent Ginhoux, Mari Tenno, Joanna Brzostek, Jackson LiangYao Li, Gabriele Allies
1 Jul 2015 Origin of Microglia: Current Concepts and Past Controversies Florent Ginhoux, Marco Prinz
9 Jun 2015 DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance Patricia Conde, Mercedes Rodriguez, William van der Touw, Ana Jimenez, Matthew Burns, Jennifer Miller, Manisha Brahmachary, Hui-ming Chen, Peter Boros, Francisco Rausell-Palamos, Tae Jin Yun, Paloma Riquelme, Alberto Rastrojo, Begoña Aguado, Joan Stein-Streilein, Masato Tanaka, Lan Zhou, Junfeng Zhang, Todd L. Lowary, Florent Ginhoux, Chae Gyu Park, Cheolho Cheong, Joshua Brody, Shannon J. Turley, Sergio A. Lira, Vincenzo Bronte, Siamon Gordon, Peter S. Heeger, Miriam Merad, James Hutchinson, Shu-Hsia Chen, Jordi Ochando
8 Jun 2015 Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow Andreas Schlitzer, V Sivakamasundari, Jinmiao Chen, Hermi Rizal Bin Sumatoh, Jaring Schreuder, Josephine Lum, Benoit Malleret, Sanqian Zhang, Anis Larbi, Francesca Zolezzi, Laurent Renia, Michael Poidinger, Shalin Naik, Evan W Newell, Paul Robson, Florent Ginhoux
13 May 2015 Poised for action: USP18 restrains microglial activation in the white matter Kazuyuki Takata, Florent Ginhoux
13 May 2015 Liver Inflammation Abrogates Immunological Tolerance Induced by Kupffer Cells Felix Heymann, Julia Peusquens, Isis Ludwig-Portugall, Marlene Kohlhepp, Can Ergen, Patricia Niemietz, Christian Martin, Nico van Rooijen, Jordi C. Ochando, Gwendalyn J. Randolph, Tom Luedde, Florent Ginhoux, Christian Kurts, Christian Trautwein, Frank Tacke
6 May 2015 Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems Andreas Schlitzer, Naomi McGovern, Florent Ginhoux
21 Apr 2015 C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages Guillaume Hoeffel, Jinmiao Chen, Peter See, Anna E. Beaudin, Yonit Lavin, Donovan Low, Francisca F. Almeida, Josephine Lum, Ivy Low, E. Camilla Forsberg, Michael Poidinger, Francesca Zolezzi, Anis Larbi, Lai Guan Ng, Jerry K.Y. Chan, Melanie Greter, Burkhard Becher, Igor M. Samokhvalov, Miriam Merad, Florent Ginhoux
9 Mar 2015 The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin Wen Hao Neo, Liang Yao Jackson Li, Myint Khun La Win, Heidi Berger, Jong Fu Wong, Merry Gunawan, Nandini Venkatesan, Jia Tong Loh, Yin Hoe Yau, Tiannan Guo, Peter Chi Ee See, Sayuri Yamazaki, Keh Chuang Chin, Alexandre R Gingras, Susana Geifman Shochat, Lai Guan Ng, Siu Kwan Sze, Florent Ginhoux, I-Hsin Su
1 Jun 2014 Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39 Rossella Melchiotti, Kia Joo Puan, Anand Kumar Andiappan, Tuang Yeow Poh, Mireille Starke, Li Zhuang, Kerstin Petsch, Tuck Siong Lai, Fook Tim Chew, Anis Larbi, De Yun Wang, Michael Poidinger, Olaf Rotzschke
21 Apr 2014 CD11b+ DCs rediscovered: implications for vaccination Florent Ginhoux, Andreas Schlitzer
5 Feb 2014 Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration H. L. Malech, X. Wu, S. S. De Ravin, L. Su, N. Theobald, U. Choi, J. L. Macpherson, M. Poidinger, G. Symonds, S. M. Pond, A. L. Ferris, S. H. Hughes
21 Jan 2014 ArchiLD: Hierarchical Visualization of Linkage Disequilibrium in Human Populations Rossella Melchiotti, Olaf Rotzschke, Michael Poidinger