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27 Aug 2020
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BMRC
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Bioprocessing Technology Institute
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Clustering and Curation of Electropherograms: An Efficient Method for Analysing Large Cohorts of Glycomic Profiles in Tracking the Effects of Multivariate Parameters in Bioprocessing Operations
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Walsh Ian,
Choo Matthew S F,
Chiin Sim Lyn,
Mak Amelia,
Tay Shi Jie,
Rudd Pauline M,
Yuansheng Yang,
Choo Andre,
Ying Swan Ho,
Nguyen-Khuong Terry
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Beilstein Journal of Organic Chemistry
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11 Aug 2020
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BMRC
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Bioprocessing Technology Institute
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A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins
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Kae Hwan Sim,
Lillian Chia-Yi Liu,
Hwee Tong Tan,
Kelly Tan,
Daniel Ng,
Wei Zhang,
Yuansheng Yang,
Stephen Tate,
Xuezhi Bi
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Scientific Data
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2 Aug 2018
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BMRC
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Bioprocessing Technology Institute
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Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer
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Heng Liang Tan,
Charlene Yong,
Bao Zhu Tan,
Wey Jia Fong,
Jayanthi Padmanabhan,
Angela Chin,
Vanessa Ding,
Ally Lau,
Lu Zheng,
Xuezhi Bi,
Yuansheng Yang,
Andre Choo
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Scientific Reports
|
|
10 Jan 2018
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BMRC
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Bioprocessing Technology Institute
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Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448
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Simeon Cua,
Heng Liang Tan,
Wey Jia Fong,
Angela Chin,
Ally Lau,
Vanessa Ding,
Zhiwei Song,
Yuansheng Yang,
Andre Choo
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Oncotarget
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25 Jan 2016
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BMRC
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Bioprocessing Technology Institute
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Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
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Peiqing Zhang,
Susanto Woen,
Tianhua Wang,
Brian Liau,
Sophie Zhao,
Chen Chen,
Yuansheng Yang,
Zhiwei Song,
Mark R. Wormald,
Chuanfei Yu,
Pauline M. Rudd
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Drug Discovery Today
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19 Dec 2015
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BMRC
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Bioprocessing Technology Institute
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Advance chromatin extraction improves capture performance of protein A affinity chromatography
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Rui Nian,
Wei Zhang,
Lihan Tan,
Jeremy Lee,
Xuezhi Bi,
Yuansheng Yang,
Hui Theng Gan,
Pete Gagnon
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Journal of Chromatography A
|
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16 Oct 2015
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BMRC
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Bioprocessing Technology Institute
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Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies
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Kah Fai Chan,
Wahyu Shahreel,
Corrine Wan,
Gavin Teo,
Noor Hayati,
Shi Jie Tay,
Wen Han Tong,
Yuansheng Yang,
Pauline M. Rudd,
Peiqing Zhang,
Zhiwei Song
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Biotechnology Journal
|
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12 Oct 2015
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BMRC
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Bioprocessing Technology Institute
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Impact of Using Different Promoters and Matrix Attachment Regions on Recombinant Protein Expression Level and Stability in Stably Transfected CHO Cells
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Steven C. L. Ho,
Mariati,
Jessna H. M. Yeo,
Shiyi Goh Fang,
Yuansheng Yang
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Molecular Biotechnology
|
|
8 Jul 2015
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BMRC
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Bioprocessing Technology Institute
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Non-immunospecific association of immunoglobulin G with chromatin during elution from protein A inflates host contamination, aggregate content, and antibody loss
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Pete Gagnon,
Rui Nian,
Yuansheng Yang,
Qiaohui Yang,
Chiew Ling Lim
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Journal of Chromatography A
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28 Mar 2015
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BMRC
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Bioprocessing Technology Institute
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Characterization of DNA in cell culture supernatant by fluorescence-detection size-exclusion chromatography
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Lihan Tan,
Veronica Yeo,
Yuansheng Yang,
Pete Gagnon
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Analytical and Bioanalytical Chemistry
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11 Mar 2015
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BMRC
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Bioprocessing Technology Institute
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Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells
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Jake Chng,
Tianhua Wang,
Rui Nian,
Ally Lau,
Kong Meng Hoi,
Steven C. L. Ho,
Peter Gagnon,
Xuezhi Bi,
Yuansheng Yang
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mAbs
|
|
6 Mar 2015
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BMRC
|
Bioprocessing Technology Institute
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IgG aggregation mechanism for CHO cell lines expressing excess heavy chains and strategies to reduce the aggregates
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Steven C. L. Ho,
Tianhua Wang,
Zhiwei Song,
Yuansheng Yang
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Molecular Biotechnology
|
|
23 Feb 2015
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BMRC
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Bioprocessing Technology Institute
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Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells
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Ryan Haryadi,
Steven Ho,
Yee Jiun Kok,
Helen X. Pu,
Lu Zheng,
Natasha A. Pereira,
Bin Li,
Xuezhi Bi,
Lin-Tang Goh,
Yuansheng Yang,
Zhiwei Song
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PLOS ONE
|
|
25 Nov 2014
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BMRC
|
Bioprocessing Technology Institute
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Chromatin-Mediated Depression of Fractionation Performance on Electronegative Multimodal Chromatography Media, its Prevention, and Ramifications for Purification of Immunoglobulin G
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Pete Gagnon,
Rui Nian,
Lihan Tan,
Jason Cheong,
Veronica Yeo,
Yuansheng Yang,
Hui Theng Gan
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Journal of Chromatography A
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|
23 Jul 2014
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BMRC
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Bioprocessing Technology Institute
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Toward stable gene expression in CHO cells
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Mariati Mariati,
Esther Y.C Koh,
Jessna H.M. Yeo,
Steven C.L. Ho,
Yuansheng Yang
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Bioengineered
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23 Jun 2014
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BMRC
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Bioprocessing Technology Institute
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Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells
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Wan Ping Loh,
Bernard Loo,
Peiqing Zhang,
Dong-Yup Lee,
Yuansheng Yang,
Kong Peng Lam,
Lihan Zhou
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Biotechnology Journal
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10 May 2014
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BMRC
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Bioprocessing Technology Institute
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Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells
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Mariati Mariati,
Jessna H. M. Yeo,
Esther Y. C. Koh,
Steven C. L. Ho,
Yuansheng Yang
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Biotechnology Progress
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16 Apr 2014
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BMRC
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Bioprocessing Technology Institute
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Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells
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Steven C. L. Ho,
Yuansheng Yang
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Biotechnology Letters
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11 Mar 2014
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BMRC
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Bioprocessing Technology Institute
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Nonspecific interactions of chromatin with immunoglobulin G and protein A, and their impact on purification performance
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Pete Gagnon,
Rui Nian,
Jeremy Lee,
Lihan Tan,
Sarah Maria Abdul Latiff,
Chiew Ling Lim,
Cindy Chuah,
Xuezhi Bi,
Yuansheng Yang,
Wei Zhang,
Hui Theng Gan
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Journal of Chromatography A
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9 Dec 2013
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BMRC
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Bioprocessing Technology Institute
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An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells
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Esther Y. C. Koh,
Steven C. L. Ho,
Mariati Mariati,
Zhiwei Song,
Xuezhi Bi,
Muriel Bardor,
Yuansheng Yang
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PLoS ONE
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