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22 Apr 2023
BMRC
Bioprocessing Technology Institute
Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content
Sean Chia,
Shi Jie Tay,
Zhiwei Song,
Yuansheng Yang,
Ian Walsh,
Kuin Tian Pang
Biomedicine & Pharmacotherapy
25 Jan 2023
BMRC
Bioprocessing Technology Institute
Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step
Serene W. Chen,
Zi Ying Zheng,
Farouq Bin Mahfut,
Yuansheng Yang,
Masahiro Ogino,
Kazuo Okada,
Kohei Sato,
Wei Zhang
PLOS ONE
4 Jul 2022
BMRC
Bioprocessing Technology Institute
Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography
Serene W. Chen,
Kong Meng Hoi,
Farouq Bin Mahfut,
Yuansheng Yang,
Wei Zhang
Bioresources and Bioprocessing
27 Aug 2020
BMRC
Bioprocessing Technology Institute
Clustering and Curation of Electropherograms: An Efficient Method for Analysing Large Cohorts of Glycomic Profiles in Tracking the Effects of Multivariate Parameters in Bioprocessing Operations
Walsh Ian,
Choo Matthew S F,
Chiin Sim Lyn,
Mak Amelia,
Tay Shi Jie,
Rudd Pauline M,
Yuansheng Yang,
Choo Andre,
Ying Swan Ho,
Nguyen-Khuong Terry
Beilstein Journal of Organic Chemistry
11 Aug 2020
BMRC
Bioprocessing Technology Institute
A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins
Kae Hwan Sim,
Lillian Chia-Yi Liu,
Hwee Tong Tan,
Kelly Tan,
Daniel Ng,
Wei Zhang,
Yuansheng Yang,
Stephen Tate,
Xuezhi Bi
Scientific Data
2 Aug 2018
BMRC
Bioprocessing Technology Institute
Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer
Heng Liang Tan,
Charlene Yong,
Bao Zhu Tan,
Wey Jia Fong,
Jayanthi Padmanabhan,
Angela Chin,
Vanessa Ding,
Ally Lau,
Lu Zheng,
Xuezhi Bi,
Yuansheng Yang,
Andre Choo
Scientific Reports
10 Jan 2018
BMRC
Bioprocessing Technology Institute
Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448
Simeon Cua,
Heng Liang Tan,
Wey Jia Fong,
Angela Chin,
Ally Lau,
Vanessa Ding,
Zhiwei Song,
Yuansheng Yang,
Andre Choo
Oncotarget
25 Jan 2016
BMRC
Bioprocessing Technology Institute
Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
Peiqing Zhang,
Susanto Woen,
Tianhua Wang,
Brian Liau,
Sophie Zhao,
Chen Chen,
Yuansheng Yang,
Zhiwei Song,
Mark R. Wormald,
Chuanfei Yu,
Pauline M. Rudd
Drug Discovery Today
19 Dec 2015
BMRC
Bioprocessing Technology Institute
Advance chromatin extraction improves capture performance of protein A affinity chromatography
Rui Nian,
Wei Zhang,
Lihan Tan,
Jeremy Lee,
Xuezhi Bi,
Yuansheng Yang,
Hui Theng Gan,
Pete Gagnon
Journal of Chromatography A
16 Oct 2015
BMRC
Bioprocessing Technology Institute
Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies
Kah Fai Chan,
Wahyu Shahreel,
Corrine Wan,
Gavin Teo,
Noor Hayati,
Shi Jie Tay,
Wen Han Tong,
Yuansheng Yang,
Pauline M. Rudd,
Peiqing Zhang,
Zhiwei Song
Biotechnology Journal
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