Dharmesh Kumar, Sridhar Idapalapati, Wang Wei, Microstructural Response and Strain Hardening in Deep Cold Rolled Nickel-based Superalloy for Aerospace Application, Procedia CIRP, Volume 71, 2018, Pages 374-379, ISSN 2212-8271, https://doi.org/10.1016/j.procir.2018.05.044.0022-2623
Abstract:
Protein Kinase C iota (PKC-i) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of fragment library has identified several hits, from which an azaindole-based scaffold was chosen for optimization. Driven by structure-activity relationship and supported by molecular modelling, a weakly bound fragment was systematically grown into a potent and selective inhibitor against PKC-i.
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Funding Info:
Agency for Science, Technology and Research (A*STAR) Joint Council grant 1231B105