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11 Aug 2018
Others
Experimental Drug Development Centre
Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria
Soo Yei Ho,
Weiling Wang,
Fui Mee Ng,
Yun Xuan Wong,
Zhi Ying Poh,
Wai Sum Eldwin Tan,
Shi Hua Ang,
Si Si Liew,
Yin Sze Joyner Wong,
Yvonne Tan,
Anders Poulsen,
Vishal Pendharkar,
Kanda Sangthongpitag,
John Manchester,
Gregory Basarab,
Jeffrey Hill,
Thomas H. Keller,
Joseph Cherian
European Journal of Medicinal Chemistry
24 Apr 2018
Others
Experimental Drug Development Centre
Fragment-based drug discovery of potent Protein Kinase C-iota inhibitors
Jacek Kwiatkowski,
Boping Liu,
Doris Hui Ying Tee,
Guoying Chen,
Nur Huda Binte Ahmad,
Yun Xuan Wong,
Zhi Ying Poh,
Shi Hua Ang,
Eldwin Sum Wai Tan,
Esther Ong,
Nurul Dinie,
Anders Poulsen,
Vishal Pendharkar,
Kanda Sangthongpitag,
May Ann Lee,
Sugunavathi D/O Sepramaniam,
Soo Yei Ho,
Joseph Cherian,
Jeffrey Hill,
Thomas Hugo Keller,
Alvin Wei Hung
Journal of Medicinal Chemistry
24 Mar 2016
Others
Experimental Drug Development Centre
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 & 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells
Kassoum Nacro,
Zhi Ying Poh,
Samantha Guo,
Joseph Cherian,
Duraiswamy Jeyaraj,
Yun Xuan Wong,
Melvyn Ho,
Hai Yan Yang,
Joma Kanikadu Joy,
Zekui Perlyn Kwek,
Boping Liu,
John Laing Kuan Wee Wee,
Esther Hq Ong,
Meng Ling Choong,
Anders Poulsen,
May Ann Lee,
Vishal Pendharkar,
Vithya Manoharan,
Yun Shan Chew,
Kanda Sangthongpitag,
Sharon Lim,
S. Tiong Ong,
Jeffrey Hill,
Thomas H. Keller
Journal of Medicinal Chemistry
4 Nov 2015
Others
Experimental Drug Development Centre
Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor.
Boping Liu,
CongBao Kang,
Yan Li,
Joseph Cherian,
Hui Qi Ng,
Michelle Yueqi Lee,
Nur Huda Ahmad,
Zhi Ying Poh,
Yun Xuan Wong,
Qiwei Huang,
Ying Lei Wong,
Alvin Hung,
Jeffrey Hill,
Thomas Keller
Biophysical Journal
17 Oct 2015
Others
Experimental Drug Development Centre
Characterization of the interaction between E. coli topoisomerase IV E subunit and an ATP competitive inhibitor.
Thomas Hugo Keller,
CongBao Kang,
Yan Li,
Ying Lei Wong,
Fui Mee Ng,
Boping Liu,
Yun Xuan Wong,
Zhi Ying Poh,
Siew Wen Then,
Michelle Lee,
Hui Qi Ng,
Alvin Hung,
Joseph Cherian,
Jeffrey Hill
Biochemical and Biophysical Research Communications
10 Aug 2015
Others
Experimental Drug Development Centre
NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.
Yan Li,
Yun Xuan Wong,
Zhi Ying Poh,
Ying Lei Wong,
Michelle Yueqi Lee,
Hui Qi Ng,
Boping Liu,
Alvin Hung,
Joseph Cherian,
Jeffrey Hill,
Thomas Hugo Keller,
CongBao Kang
FEBS Letters
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