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Publication date Communities Collections Article title Author(s)
25 Mar 2021 BMRC Institute of Molecular and Cell Biology Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione
7 Jun 2019 BMRC Experimental Drug Development Centre Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Qianhui Nah, Yee Hwa Wong, Jeffrey Hill, Julien Lescar, Peter C. Dedon, CongBao Kang
10 Jan 2019 BMRC Bioinformatics Institute Perspective: The promises of a holistic view of proteins - impact on antibody engineering and drug discovery Ser-Xian Phua, Kwok-Fong Chan, Chinh Tran-To Su, Jun-Jie Poh, Samuel Ken-En Gan
11 May 2018 BMRC Experimental Drug Development Centre Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2. Qiu Ying Lau, Jianguo Li, Marc-Antoine Sani, Sheetal Sinha, Yan Li, Ng Fui Mee, Kang CongBao, Bhattacharjya Surajit, Separovic Frances, Verma Chandra, Chia Brian
8 May 2018 BMRC Experimental Drug Development Centre Phenotypic screening for inhibitors of a mutant thrombopoietin receptor Anna Ngo, Ann Koay, Christian Pecquet, Meng Ling Choong, Carmen Diaconu, David Jenkins, Andrew Shiau, Stefan Constantinescu
24 Apr 2018 BMRC Experimental Drug Development Centre Fragment-based drug discovery of potent Protein Kinase C-iota inhibitors Jacek Kwiatkowski, Boping Liu, Doris Hui Ying Tee, Guoying Chen, Nur Huda Binte Ahmad, Yun Xuan Wong, Zhi Ying Poh, Shi Hua Ang, Eldwin Sum Wai Tan, Esther Ong, Nurul Dinie, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, May Ann Lee, Sugunavathi D/O Sepramaniam, Soo Yei Ho, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, Alvin Wei Hung
9 Mar 2018 BMRC Experimental Drug Development Centre Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans Shawn Hoon, Siew Mei Samantha Ng, Jia Mao Yap, Qiu Ying Lau, Fui Mee Ng, Esther Ong, Timothy Barkham, Jeanette Teo, Alfatah Mohammad, Kiat Whye Kong, Prakash Arumugam, Jeffrey Hill, Brian Chia
22 Jan 2018 BMRC Experimental Drug Development Centre Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent Roland Jureen, Jeffrey Hill, Cheng San Brian Chia, Shu Wei Teo, Yaqing Elena Yong, Siew Mei Samantha Ng, Fui Mee Ng, Jeanette Teo
14 Aug 2017 BMRC Experimental Drug Development Centre Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor Thomas Hugo Keller, CongBao Kang, Yan Li, Hui Qi Ng, Anna Ngo, Joma Joy, Jeffrey Hill, Pearlyn Kwek, Alvin Hung
5 Aug 2017 BMRC Experimental Drug Development Centre Zika Virus Protease: An Antiviral Drug Target CongBao Kang, Thomas Keller, Dahai Luo
20 Jul 2017 BMRC Experimental Drug Development Centre Structural characterization of the linked NS2B-NS3 protease of Zika virus Wint Wint Phoo, Weiling Wang, Ying Ru Loh, Zhenzhen Zhang, Elizabeth Yihui Ng, Thomas Hugo Keller, Dahai Luo, CongBao Kang, Yan Li
7 Mar 2017 BMRC Experimental Drug Development Centre Discovery and characterisation of the automethylation properties of PRDM9 Xiaoying Koh-Stenta, Anders Poulsen, Rong Li, John Liang Kuan Wee, Perlyn Zekui Kwek, Sin Yin Chew, Jianhe Peng, Liling Wu, Ernesto Guccione, Joma Joy, Jeffrey Hill
4 Feb 2017 BMRC Experimental Drug Development Centre Screening for a Potent Antibacterial Peptide to Treat Mupirocin- Resistant MRSA Skin Infections Siew Mei Samantha Ng, Hui Si Vivian Ching, GuiFang Xu, Fui Mee Ng, Esther H. Q. Ong, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, C. S. Brian Chia
19 Jan 2017 BMRC Experimental Drug Development Centre Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans Yi Yong Alvin Yap, Timothy Barkham, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Siew Mei Samantha Ng, Jeanette Woon Pei Teo, Jeffrey Hill, C. S. Brian Chia
5 Dec 2016 BMRC Bioinformatics Institute Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer Mareike M. Wiedmann, Yaw Sing Tan, Yuteng Wu, Shintaro Aibara, Wenshu Xu, Hannah F. Sore, Chandra S. Verma, Laura Itzhaki, Murray Stewart, James D. Brenton, David R. Spring
18 Oct 2016 BMRC Experimental Drug Development Centre A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms. Zhufang Ann Koay, Christian Pecquet, Carmen Diaconu, Yasmine Ould-Amer, CongBao Kang, Anders Poulsen, May Ann Lee, David Jenkins, Andrew Shiau, Stefan Constantinescu, Anna Ngo, Meng Ling Choong
24 Mar 2016 BMRC Experimental Drug Development Centre Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 & 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells Kassoum Nacro, Zhi Ying Poh, Samantha Guo, Joseph Cherian, Duraiswamy Jeyaraj, Yun Xuan Wong, Melvyn Ho, Hai Yan Yang, Joma Kanikadu Joy, Zekui Perlyn Kwek, Boping Liu, John Laing Kuan Wee Wee, Esther Hq Ong, Meng Ling Choong, Anders Poulsen, May Ann Lee, Vishal Pendharkar, Vithya Manoharan, Yun Shan Chew, Kanda Sangthongpitag, Sharon Lim, S. Tiong Ong, Jeffrey Hill, Thomas H. Keller
4 Nov 2015 BMRC Experimental Drug Development Centre Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor. Boping Liu, CongBao Kang, Yan Li, Joseph Cherian, Hui Qi Ng, Michelle Yueqi Lee, Nur Huda Ahmad, Zhi Ying Poh, Yun Xuan Wong, Qiwei Huang, Ying Lei Wong, Alvin Hung, Jeffrey Hill, Thomas Keller
23 Oct 2015 BMRC Experimental Drug Development Centre The use of porcupine inhibitors to target Wnt-driven cancers Soo Yei Ho, Thomas Keller
9 Oct 2015 BMRC Experimental Drug Development Centre An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA). Qiu Ying Lau, Yoke Yan Fion Tan, Vanessa Chai Yin Goh, David Jing Qin Lee, Fui Mee Ng, Esther H. Q. Ong, Jeffrey Hill, Cheng San Brian Chia
10 Aug 2015 BMRC Experimental Drug Development Centre NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor. Yan Li, Yun Xuan Wong, Zhi Ying Poh, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, Boping Liu, Alvin Hung, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, CongBao Kang
24 Jun 2015 BMRC Experimental Drug Development Centre Application of Fragment-Based Drug Discovery against DNA Gyrase B Cheng San Brian Chia, Qiu Ying Lau, Jeffrey Hill, Alvin Hung, Thomas Keller, Siew Wen Then, Nur Huda Ahmad, Ying Lei Wong, Hui Qi Ng, Guo-Ying Chen, Fui Mee Ng, Yih Wan Tan, Anders Poulsen, Wei Guang Seetoh, Grace Lin, CongBao Kang
29 May 2015 BMRC Experimental Drug Development Centre A Pharmacophore Model for Wnt/Porcupine Inhibitors and its Use for Drug Design Grace Ruiting Lin, Vivien Wei Wen Cheong, Zhiyuan Ke, May Ann Lee, Thomas Keller, Anders Poulsen, Soo Yei Ho, Weiling Wang, Jenefer Alam, Duraiswamy Jeyaraj, Shi Hua Ang, Eldwin Sum Wai Tan
5 May 2015 BMRC Experimental Drug Development Centre Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria Horst Flotow, Jeffrey Hill, Ravikiran Raju, Wilfried Moreira, Grace Ngan, Jian Liang Low, Anders Poulsen, Brian Chia, Melgious Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim, Audrey Khoo, Eric Rubin, Thomas Dick