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19 Jul 2022
Others
Experimental Drug Development Centre
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir
Subramanyam Vankadara,
Monique Danielle Dawson,
Jia Yi Fong,
Qin Yao Oh,
Qi An Ang,
Boping Liu,
Hong Yun Chang,
Judice Koh,
Xiaoying Koh,
Qian Wen Tan,
Joma Joy,
Cheng San Brian Chia
ACS Medicinal Chemistry Letters
14 Jul 2021
Others
Experimental Drug Development Centre
A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors
Subramanyam Vankadara,
Yun Xuan Wong,
Boping Liu,
Yi Yang See,
Li Hong Tan,
Qian Wen Tan,
Gang Wang,
Ratna Karuna,
Xue Guo,
Shu Ting Tan,
Jia Yi Fong,
Joma Joy,
C.S. Brian Chia
Bioorganic & Medicinal Chemistry Letters
24 Apr 2018
Others
Experimental Drug Development Centre
Fragment-based drug discovery of potent Protein Kinase C-iota inhibitors
Jacek Kwiatkowski,
Boping Liu,
Doris Hui Ying Tee,
Guoying Chen,
Nur Huda Binte Ahmad,
Yun Xuan Wong,
Zhi Ying Poh,
Shi Hua Ang,
Eldwin Sum Wai Tan,
Esther Ong,
Nurul Dinie,
Anders Poulsen,
Vishal Pendharkar,
Kanda Sangthongpitag,
May Ann Lee,
Sugunavathi D/O Sepramaniam,
Soo Yei Ho,
Joseph Cherian,
Jeffrey Hill,
Thomas Hugo Keller,
Alvin Wei Hung
Journal of Medicinal Chemistry
23 Apr 2018
BMRC
Bioinformatics Institute
Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia
Haiyan Yang,
Lohitha Rao Chennamaneni,
Melvyn Wai Tuck Ho,
Shi Hua Ang,
Eldwin Sum Wai Tan,
Duraiswamy Athisayamani Jeyaraj,
Yoon Sheng Yeap,
Boping Liu,
Esther Hq Ong,
Joma Kanikadu Joy,
John Liang Kuan Wee,
Perlyn Kwek,
Priya Retna,
Nurul Dinie,
Thuy Thi Hanh Nguyen,
Shi Jing Tai,
Vithya Manoharan,
Vishal Pendharkar,
Choon Bing Low,
Yun Shan Chew,
Susmitha Vuddagiri,
Kanda Sangthongpitag,
Meng Ling Choong,
May Ann Lee,
Srinivasaraghavan Kannan,
Chandra S. Verma,
Anders Poulsen,
Sharon Lim,
Charles Chuah,
Tiong Sin Ong,
Jeffrey Hill,
Alex Matter,
Kassoum Nacro
Journal of Medicinal Chemistry
30 Jun 2016
Others
Experimental Drug Development Centre
Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy
Yan Li,
Ying Lei Wong,
Fui Mee Ng,
Boping Liu,
Yun Xuan Wong,
Zhin Ying Poh,
Shuang Liu,
Siew Wen Then,
Michelle Yueqi Lee,
Hui Qi Ng,
Qiwei Huang,
Alvin W Hung,
Joseph Cherian,
Jeffrey Hill,
Thomas H Keller,
CongBao Kang
Journal of Biological Chemistry
24 Mar 2016
Others
Experimental Drug Development Centre
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 & 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells
Kassoum Nacro,
Zhi Ying Poh,
Samantha Guo,
Joseph Cherian,
Duraiswamy Jeyaraj,
Yun Xuan Wong,
Melvyn Ho,
Hai Yan Yang,
Joma Kanikadu Joy,
Zekui Perlyn Kwek,
Boping Liu,
John Laing Kuan Wee Wee,
Esther Hq Ong,
Meng Ling Choong,
Anders Poulsen,
May Ann Lee,
Vishal Pendharkar,
Vithya Manoharan,
Yun Shan Chew,
Kanda Sangthongpitag,
Sharon Lim,
S. Tiong Ong,
Jeffrey Hill,
Thomas H. Keller
Journal of Medicinal Chemistry
4 Nov 2015
Others
Experimental Drug Development Centre
Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor.
Boping Liu,
CongBao Kang,
Yan Li,
Joseph Cherian,
Hui Qi Ng,
Michelle Yueqi Lee,
Nur Huda Ahmad,
Zhi Ying Poh,
Yun Xuan Wong,
Qiwei Huang,
Ying Lei Wong,
Alvin Hung,
Jeffrey Hill,
Thomas Keller
Biophysical Journal
17 Oct 2015
Others
Experimental Drug Development Centre
Characterization of the interaction between E. coli topoisomerase IV E subunit and an ATP competitive inhibitor.
Thomas Hugo Keller,
CongBao Kang,
Yan Li,
Ying Lei Wong,
Fui Mee Ng,
Boping Liu,
Yun Xuan Wong,
Zhi Ying Poh,
Siew Wen Then,
Michelle Lee,
Hui Qi Ng,
Alvin Hung,
Joseph Cherian,
Jeffrey Hill
Biochemical and Biophysical Research Communications
10 Aug 2015
Others
Experimental Drug Development Centre
NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.
Yan Li,
Yun Xuan Wong,
Zhi Ying Poh,
Ying Lei Wong,
Michelle Yueqi Lee,
Hui Qi Ng,
Boping Liu,
Alvin Hung,
Joseph Cherian,
Jeffrey Hill,
Thomas Hugo Keller,
CongBao Kang
FEBS Letters
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