Experimental Drug Development Centre

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Publication date Article title Author(s)
7 Aug 2025 Discovery of an Orally Bioavailable Reversible Covalent SARS-CoV-2 Mpro Inhibitor with Pan-Coronavirus Activity Qian Wen Tan, Subramanyam Vankadara, Jia Yi Fong, Yi Yang See, Nithya Baburajendran, Pearly Shuyi Ng, Weijun Xu, Yee Khoon Yeo, Weiling Wang, Choon Heng Low, Li Hong Tan, Eileen Gui Ju Tay, Yun Xuan Wong, Chuhui Huang, Sandra Sim, Shi Hua Ang, Hannah Hui Min Toh, Juliana Mohammad, Gang Wang, Boping Liu, Shu Ting Tan, Perlyn Zekui Kwek, Monique Danielle Dawson, Qin Yao Oh, Xiaoying Koh, Joma Joy, May Ann Lee, Walter Stunkel, Vishal Pendharkar, Hannes Hentze, Siew Pheng Lim, Kantharaj Ethirajulu, C. S. Brian Chia, Joseph Cherian
16 Jul 2025 Entry Inhibitors of SARS-CoV-2 Targeting the Transmembrane Domain of the Spike Protein Kristin V. Lyles, Shannon Stone, Priti Singh, Lila D. Patterson, Janhavi Natekar, Heather Pathak, Rohit K. Varshnaya, Amany Elsharkawy, Dongning Liu, Shubham Bansal, Oluwafoyinsola O. Faniyi, Sijia Tang, Xiaoxiao Yang, Nagaraju Mulpuri, Donald Hamelberg, CongBao Kang, Binghe Wang, Mukesh Kumar, Ming Luo
5 Dec 2024 Perspectives on Applications of 19F-NMR in Fragment-Based Drug Discovery Qingxin Li, CongBao Kang
7 Nov 2024 1H, 15N and 13C backbone resonance assignment of the N-terminal region of Zika virus NS4B protein in detergent micelles Yan Li, Ying Ru Loh, Qingxin Li, Dahai Luo, CongBao Kang
30 Oct 2024 Button-Push On-Demand Synthesis for Rapid Optimization of Antiviral Peptidomimetics Duanshuai Tian, Ting Wei Tan, Ronald Toh Kuan Hai, Gan Wang, Fadhil Peer Mohamed, Zhenyang Yu, Hwee Ting Ang, Weijun Xu, Qian Wen Tan, Pearly Shuyi Ng, Choon Heng Low, Boping Liu, Perlyn Quek Zekui, Joma Kanikadu Joy, Joseph Cherian, Frankie S Mak, Jie Wu
3 Sep 2024 Regio-MPNN: predicting regioselectivity for general metal-catalyzed cross-coupling reactions using a chemical knowledge informed message passing neural network Baochen Li, Yuru Liu, Haibin Sun, Rentao Zhang, Yongli Xie, Klement Foo, Frankie S. Mak, Ruimao Zhang, Tianshu Yu, Sen Lin, Peng Wang, Xiaoxue Wang
22 Aug 2024 Protocol to perform fragment screening using NMR spectroscopy Qiwei Huang, CongBao Kang
4 Jul 2024 Ultra-large scale virtual screening identifies a small molecule inhibitor of the Wnt transporter Wntless Jia Yu, Pei-Ju Liao, Thomas H. Keller, Joseph Cherian, David M. Virshup, Weijun Xu
23 May 2024 A high-throughput cell-based screening method for Zika virus protease inhibitor discovery Paulina Duhita Anindita, Yuka Otsuka, Simon Lattmann, Khac Huy Ngo, Chong Wai Liew, CongBao Kang, Reuben S. Harris, Louis Scampavia, Timothy P. Spicer, Dahai Luo
15 Apr 2024 Cytotoxic activity and cell specificity of a novel LHRH peptide drug conjugate, D-Cys6-LHRH vedotin, against ovarian cancer cell lines Subramanyam Vankadara, Zhiyuan Ke, Sifang Wang, Sin Yun Foo, Jayantha Gunaratne, May Ann Lee, Xiaoying Koh, C. S. Brian Chia