Experimental Drug Development Centre

Publication date Article title Author(s)
7 Jun 2019 Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Qianhui Nah, Yee Hwa Wong, Jeffrey Hill, Julien Lescar, Peter C. Dedon, CongBao Kang
23 May 2019 Discovery of Irreversible Inhibitors Targeting Histone Methyltrans-ferase, SMYD3 Chuhui Huang, Si Si Liew, Grace R Lin, Anders Poulsen, Melgious J. Y. Ang, Brian C. S. Chia, Sin Yin Chew, Zekui Perlyn Kwek, John L. K. Wee, Esther H. Ong, Priya Retna, Nithya Baburajendran, Rong Li, Weixuan Yu, Xiaoying Koh-Stenta, Anna Ngo, Sravanthy Manesh, Justina Fulwood, Zhiyuan Ke, Hwa Hwa Chung, Sugunavathi Sepramaniam, Xin Hui Chew, Nurul Dinie, Yun Shan Chew, May Ann Lee, Choon Bing Low, Vishal Pendharkar, Vithya Manoharan, Susmitha Vuddagiri, Kanda Sangthongpitag, Joma Joy, Alex Matter, Jeffrey Hill, Thomas Keller, Klement Foo
8 Oct 2018 Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Xiaoying Koh-Stenta, Qianhui Nah, Siau Hoi Lim, Andreas Larsson, Julien Lescar, Jeffrey Hill, Peter C. Dedon, CongBao Kang
21 Sep 2018 Expression, purification of Zika virus membrane protein-NS2B in detergent micelles for NMR studies Elizabeth Yihui Ng, Ying Ru Loh, Yan Li, Qingxin Li, CongBao Kang
13 Aug 2018 Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA. Giovinna Arfan, Chu Yang Fann Ong, Siew Mei Samantha Ng, Qiu Ying Lau, Fui Mee Ng, Esther Hong Qian Ong, Jeffrey Hill, C. S. Brian Chia
11 Aug 2018 Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria Soo Yei Ho, Weiling Wang, Fui Mee Ng, Yun Xuan Wong, Zhi Ying Poh, Wai Sum Eldwin Tan, Shi Hua Ang, Si Si Liew, Yin Sze Joyner Wong, Yvonne Tan, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, John Manchester, Gregory Basarab, Jeffrey Hill, Thomas H. Keller, Joseph Cherian
5 Jul 2018 Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, Cheng San Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen
21 Jun 2018 Characterization of molecular interactions between Zika virus protease and peptides derived from the C-terminus of NS2B Yan Li, Ying Ru Loh, Alvin Wei Hung, CongBao Kang
23 May 2018 Structural and ligand binding analysis of the YAP-binding domain of transcription factor TEAD4 Yan Li, Shuang Liu, Elizabeth Yihui Ng, Rong Li, Anders Poulsen, Jeffrey Hill, CongBao Kang, Ajaybabu Pobbati, Alvin Wei Hung, Wanjin Hong, Thomas Keller
11 May 2018 Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2. Qiu Ying Lau, Jianguo Li, Marc-Antoine Sani, Sheetal Sinha, Yan Li, Ng Fui Mee, Kang CongBao, Bhattacharjya Surajit, Separovic Frances, Verma Chandra, Chia Brian
8 May 2018 Phenotypic screening for inhibitors of a mutant thrombopoietin receptor Anna Ngo, Ann Koay, Christian Pecquet, Meng Ling Choong, Carmen Diaconu, David Jenkins, Andrew Shiau, Stefan Constantinescu
24 Apr 2018 Fragment-based drug discovery of potent Protein Kinase C-iota inhibitors Jacek Kwiatkowski, Boping Liu, Doris Hui Ying Tee, Guoying Chen, Nur Huda Binte Ahmad, Yun Xuan Wong, Zhi Ying Poh, Shi Hua Ang, Eldwin Sum Wai Tan, Esther Ong, Nurul Dinie, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, May Ann Lee, Sugunavathi D/O Sepramaniam, Soo Yei Ho, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, Alvin Wei Hung
9 Mar 2018 Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans Shawn Hoon, Siew Mei Samantha Ng, Jia Mao Yap, Qiu Ying Lau, Fui Mee Ng, Esther Ong, Timothy Barkham, Jeanette Teo, Alfatah Mohammad, Kiat Whye Kong, Prakash Arumugam, Jeffrey Hill, Brian Chia
6 Feb 2018 Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small molecule inhibitor Kassoum Nacro, Yan Li, Zhenzhen Zhang, Ying Ru Loh, Rong Li, Hai Yan Yang, Anna Jansson, Jeffrey Hill, Thomas Keller, Dahai Luo, CongBao Kang
22 Jan 2018 Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent Roland Jureen, Jeffrey Hill, Cheng San Brian Chia, Shu Wei Teo, Yaqing Elena Yong, Siew Mei Samantha Ng, Fui Mee Ng, Jeanette Teo
18 Oct 2017 Secondary Structure and Membrane Topology of Dengue Virus NS4A Protein in Micelles Yan Li, Michelle Yueqi Lee, Ying Ru Loh, CongBao Kang
10 Oct 2017 Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections Jaron Sioson, Jia Mao Yap, Fui Mee Ng, Vivian Ching, Jeanette Teo, Roland Jureen, Jeffrey Hill, Brian Chia, Siew Mei Samantha Ng
23 Aug 2017 Solution NMR Spectroscopy in Target-Based Drug Discovery Yan Li, CongBao Kang
14 Aug 2017 Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor Thomas Hugo Keller, CongBao Kang, Yan Li, Hui Qi Ng, Anna Ngo, Joma Joy, Jeffrey Hill, Pearlyn Kwek, Alvin Hung
5 Aug 2017 Zika Virus Protease: An Antiviral Drug Target CongBao Kang, Thomas Keller, Dahai Luo
20 Jul 2017 Structural characterization of the linked NS2B-NS3 protease of Zika virus Wint Wint Phoo, Weiling Wang, Ying Ru Loh, Zhenzhen Zhang, Elizabeth Yihui Ng, Thomas Hugo Keller, Dahai Luo, CongBao Kang, Yan Li
11 Jul 2017 Preliminary investigations into developing all-D Omiganan for treating Mupirocin-resistant MRSA skin infections Siew Mei Samantha Ng, Shu Wei Teo, Yaqing Elena Yong, Fui Mee Ng, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, Cheng San Brian Chia
6 Jul 2017 Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors Ying Ru Loh, Weiling Wang, Alvin Wei Hung, Thomas Hugo Keller, Dahai Luo, CongBao Kang, Yan Li, Zhenzhen Zhang, Wint Wint Phoo, Shuang Liu, Ming Wei Chen
7 Mar 2017 Discovery and characterisation of the automethylation properties of PRDM9 Xiaoying Koh-Stenta, Anders Poulsen, Rong Li, John Liang Kuan Wee, Perlyn Zekui Kwek, Sin Yin Chew, Jianhe Peng, Liling Wu, Ernesto Guccione, Joma Joy, Jeffrey Hill
4 Feb 2017 Screening for a Potent Antibacterial Peptide to Treat Mupirocin- Resistant MRSA Skin Infections Siew Mei Samantha Ng, Hui Si Vivian Ching, GuiFang Xu, Fui Mee Ng, Esther H. Q. Ong, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, C. S. Brian Chia
19 Jan 2017 Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans Yi Yong Alvin Yap, Timothy Barkham, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Siew Mei Samantha Ng, Jeanette Woon Pei Teo, Jeffrey Hill, C. S. Brian Chia
23 Dec 2016 Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus Yan Li, Ying Ru Loh, Wint Wint Phoo, Alvin Hung, CongBao Kang, Dahai Luo, Zhenzhen Zhang
15 Nov 2016 Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage CongBao Kang, Dahai Luo, Wint Wint Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Ying Ru Loh, Yaw Bia Tan, Elizabeth Yihui Ng, Julien Lescar
18 Oct 2016 A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms. Zhufang Ann Koay, Christian Pecquet, Carmen Diaconu, Yasmine Ould-Amer, CongBao Kang, Anders Poulsen, May Ann Lee, David Jenkins, Andrew Shiau, Stefan Constantinescu, Anna Ngo, Meng Ling Choong
24 Aug 2016 Secondary structure and membrane topology of the full length Dengue Virus NS4B in micelles Yan Li, Ying Lei Wong, Michelle Yueqi Lee, Qingxin Li, Qing-Yin Wang, Julien Lescar, CongBao Kang, Pei-Yong Shi
30 Jun 2016 Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhin Ying Poh, Shuang Liu, Siew Wen Then, Michelle Yueqi Lee, Hui Qi Ng, Qiwei Huang, Alvin W Hung, Joseph Cherian, Jeffrey Hill, Thomas H Keller, CongBao Kang
31 May 2016 Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease Anders Poulsen, John Liang Kuan Wee, Fui Mee Ng, Joma Joy, Jeffrey Hill, J. Y. Melgious Ang, C. S. Brian Chia, Huichang Annie Lim
30 Mar 2016 Structure of the transmembrane domain of human nicastrin-a component of γ-secretase Yan Li, Lynette Sin Yee Liew, Qingxin Li, CongBao Kang
24 Mar 2016 Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 & 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells Kassoum Nacro, Zhi Ying Poh, Samantha Guo, Joseph Cherian, Duraiswamy Jeyaraj, Yun Xuan Wong, Melvyn Ho, Hai Yan Yang, Joma Kanikadu Joy, Zekui Perlyn Kwek, Boping Liu, John Laing Kuan Wee Wee, Esther Hq Ong, Meng Ling Choong, Anders Poulsen, May Ann Lee, Vishal Pendharkar, Vithya Manoharan, Yun Shan Chew, Kanda Sangthongpitag, Sharon Lim, S. Tiong Ong, Jeffrey Hill, Thomas H. Keller
10 Mar 2016 Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants Ilyas Chachoua, Christian Pecquet, Mira El-Khoury, Harini Nivarthi, Roxana-Irina Albu, Caroline Marty, Vitalina Gryshkova, Jean-Philippe Defour, Gaelle Vertenoeil, Anna Ngo, Ann Koay, Hana Raslova, Meng Ling Choong, Robert Kralovics, Stefan N. Constantinescu
3 Feb 2016 Selection of suitable detergents for obtaining an active dengue protease in its natural form from E. coli Lynette Sin Yee Liew, Micelle Yueqi Lee, Ying Lei Wong, Jinting Cheng, Qingxin Li, CongBao Kang
18 Jan 2016 Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome Yan Li, Hui Qi Ng, Qingxin Li, CongBao Kang
4 Nov 2015 Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor. Boping Liu, CongBao Kang, Yan Li, Joseph Cherian, Hui Qi Ng, Michelle Yueqi Lee, Nur Huda Ahmad, Zhi Ying Poh, Yun Xuan Wong, Qiwei Huang, Ying Lei Wong, Alvin Hung, Jeffrey Hill, Thomas Keller
23 Oct 2015 The use of porcupine inhibitors to target Wnt-driven cancers Soo Yei Ho, Thomas Keller
22 Oct 2015 Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study. Alvin Yap, Qiu Ying Lau, Fui Mee Ng, Darryl Cheong, Fion Tan, Roland Jureen, Brian Chia
19 Oct 2015 Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit Yan Li, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, CongBao Kang
17 Oct 2015 Characterization of the interaction between E. coli topoisomerase IV E subunit and an ATP competitive inhibitor. Thomas Hugo Keller, CongBao Kang, Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhi Ying Poh, Siew Wen Then, Michelle Lee, Hui Qi Ng, Alvin Hung, Joseph Cherian, Jeffrey Hill
9 Oct 2015 An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA). Qiu Ying Lau, Yoke Yan Fion Tan, Vanessa Chai Yin Goh, David Jing Qin Lee, Fui Mee Ng, Esther H. Q. Ong, Jeffrey Hill, Cheng San Brian Chia
25 Sep 2015 Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids Yan Li, Xuping Xie, Qiwei Huang, Julien Lescar, Pei-Yong Shi, CongBao Kang, Young Mee Kim, Jing Zou, Qing-Yin Wang, Shovanlal Gayen, Ying Lei Wong, Le Tian Lee
28 Aug 2015 Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles. Qingxin Li, Ying Lei Wong, Michelle Yueqi Lee, Yan Li, CongBao Kang
10 Aug 2015 NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor. Yan Li, Yun Xuan Wong, Zhi Ying Poh, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, Boping Liu, Alvin Hung, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, CongBao Kang
10 Aug 2015 Wnt addiction of genetically defined cancers reversed by PORCN inhibition Babita Madan, Zhiyuan Ke, Nathan Harmston, Soo Yei Ho, Frois Ashley Oliver, Jenefer Alam, Duraiswamy Jeyaraj, Vishal Pendharkar, Kakaly Ghosh, Isaac H Virshup, Vithya Manoharan, Esther Hq Ong, Kanda Sangthongpitag, Jeffrey Hill, Enrico Petretto, Thomas Keller, May Ann Lee, Alex Matter, David M Virshup
25 Jun 2015 Discovery and Optimization of a Porcupine Inhibitor Athisayamani Jeyaraj Duraiswamy, May Ann Lee, Babita Madan, Shi Hua Ang, Eldwin Sum Wai Tan, Wei Wen Vivien Cheong, Zhiyuan Ke, Vishal Pendharkar, Li Jun Ding, Yun Shan Chew, Vithya Manoharan, Kanda Sangthongpitag, Jenefer Alam, Anders Poulsen, Soo Yei Ho, David Virshup, Thomas Hugo Keller
24 Jun 2015 Application of Fragment-Based Drug Discovery against DNA Gyrase B Cheng San Brian Chia, Qiu Ying Lau, Jeffrey Hill, Alvin Hung, Thomas Keller, Siew Wen Then, Nur Huda Ahmad, Ying Lei Wong, Hui Qi Ng, Guo-Ying Chen, Fui Mee Ng, Yih Wan Tan, Anders Poulsen, Wei Guang Seetoh, Grace Lin, CongBao Kang
11 Jun 2015 Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy Yan Li, Qingxin Li, Ying Lei Wong, Lynette Sin Yee Liew, CongBao Kang