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7 Jun 2019 BMRC Experimental Drug Development Centre Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Qianhui Nah, Yee Hwa Wong, Jeffrey Hill, Julien Lescar, Peter C. Dedon, CongBao Kang
23 May 2019 BMRC Experimental Drug Development Centre Discovery of Irreversible Inhibitors Targeting Histone Methyltrans-ferase, SMYD3 Chuhui Huang, Si Si Liew, Grace R Lin, Anders Poulsen, Melgious J. Y. Ang, Brian C. S. Chia, Sin Yin Chew, Zekui Perlyn Kwek, John L. K. Wee, Esther H. Ong, Priya Retna, Nithya Baburajendran, Rong Li, Weixuan Yu, Xiaoying Koh-Stenta, Anna Ngo, Sravanthy Manesh, Justina Fulwood, Zhiyuan Ke, Hwa Hwa Chung, Sugunavathi Sepramaniam, Xin Hui Chew, Nurul Dinie, Yun Shan Chew, May Ann Lee, Choon Bing Low, Vishal Pendharkar, Vithya Manoharan, Susmitha Vuddagiri, Kanda Sangthongpitag, Joma Joy, Alex Matter, Jeffrey Hill, Thomas Keller, Klement Foo
8 Oct 2018 BMRC Experimental Drug Development Centre Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Xiaoying Koh-Stenta, Qianhui Nah, Siau Hoi Lim, Andreas Larsson, Julien Lescar, Jeffrey Hill, Peter C. Dedon, CongBao Kang
13 Aug 2018 BMRC Experimental Drug Development Centre Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA. Giovinna Arfan, Chu Yang Fann Ong, Siew Mei Samantha Ng, Qiu Ying Lau, Fui Mee Ng, Esther Hong Qian Ong, Jeffrey Hill, C. S. Brian Chia
11 Aug 2018 BMRC Experimental Drug Development Centre Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria Soo Yei Ho, Weiling Wang, Fui Mee Ng, Yun Xuan Wong, Zhi Ying Poh, Wai Sum Eldwin Tan, Shi Hua Ang, Si Si Liew, Yin Sze Joyner Wong, Yvonne Tan, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, John Manchester, Gregory Basarab, Jeffrey Hill, Thomas H. Keller, Joseph Cherian
5 Jul 2018 BMRC Experimental Drug Development Centre Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, Cheng San Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen
5 Jul 2018 BMRC Bioinformatics Institute Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, C. S. Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora X. Y. Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen
23 May 2018 BMRC Experimental Drug Development Centre Structural and ligand binding analysis of the YAP-binding domain of transcription factor TEAD4 Yan Li, Shuang Liu, Elizabeth Yihui Ng, Rong Li, Anders Poulsen, Jeffrey Hill, CongBao Kang, Ajaybabu Pobbati, Alvin Wei Hung, Wanjin Hong, Thomas Keller
24 Apr 2018 BMRC Experimental Drug Development Centre Fragment-based drug discovery of potent Protein Kinase C-iota inhibitors Jacek Kwiatkowski, Boping Liu, Doris Hui Ying Tee, Guoying Chen, Nur Huda Binte Ahmad, Yun Xuan Wong, Zhi Ying Poh, Shi Hua Ang, Eldwin Sum Wai Tan, Esther Ong, Nurul Dinie, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, May Ann Lee, Sugunavathi D/O Sepramaniam, Soo Yei Ho, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, Alvin Wei Hung
23 Apr 2018 BMRC Bioinformatics Institute Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia Haiyan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, Shi Hua Ang, Eldwin Sum Wai Tan, Duraiswamy Athisayamani Jeyaraj, Yoon Sheng Yeap, Boping Liu, Esther Hq Ong, Joma Kanikadu Joy, John Liang Kuan Wee, Perlyn Kwek, Priya Retna, Nurul Dinie, Thuy Thi Hanh Nguyen, Shi Jing Tai, Vithya Manoharan, Vishal Pendharkar, Choon Bing Low, Yun Shan Chew, Susmitha Vuddagiri, Kanda Sangthongpitag, Meng Ling Choong, May Ann Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Anders Poulsen, Sharon Lim, Charles Chuah, Tiong Sin Ong, Jeffrey Hill, Alex Matter, Kassoum Nacro
9 Mar 2018 BMRC Experimental Drug Development Centre Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans Shawn Hoon, Siew Mei Samantha Ng, Jia Mao Yap, Qiu Ying Lau, Fui Mee Ng, Esther Ong, Timothy Barkham, Jeanette Teo, Alfatah Mohammad, Kiat Whye Kong, Prakash Arumugam, Jeffrey Hill, Brian Chia
6 Feb 2018 BMRC Experimental Drug Development Centre Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small molecule inhibitor Kassoum Nacro, Yan Li, Zhenzhen Zhang, Ying Ru Loh, Rong Li, Hai Yan Yang, Anna Jansson, Jeffrey Hill, Thomas Keller, Dahai Luo, CongBao Kang
22 Jan 2018 BMRC Experimental Drug Development Centre Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent Roland Jureen, Jeffrey Hill, Cheng San Brian Chia, Shu Wei Teo, Yaqing Elena Yong, Siew Mei Samantha Ng, Fui Mee Ng, Jeanette Teo
10 Oct 2017 BMRC Experimental Drug Development Centre Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections Jaron Sioson, Jia Mao Yap, Fui Mee Ng, Vivian Ching, Jeanette Teo, Roland Jureen, Jeffrey Hill, Brian Chia, Siew Mei Samantha Ng
14 Aug 2017 BMRC Experimental Drug Development Centre Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor Thomas Hugo Keller, CongBao Kang, Yan Li, Hui Qi Ng, Anna Ngo, Joma Joy, Jeffrey Hill, Pearlyn Kwek, Alvin Hung
11 Jul 2017 BMRC Experimental Drug Development Centre Preliminary investigations into developing all-D Omiganan for treating Mupirocin-resistant MRSA skin infections Siew Mei Samantha Ng, Shu Wei Teo, Yaqing Elena Yong, Fui Mee Ng, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, Cheng San Brian Chia
7 Mar 2017 BMRC Experimental Drug Development Centre Discovery and characterisation of the automethylation properties of PRDM9 Xiaoying Koh-Stenta, Anders Poulsen, Rong Li, John Liang Kuan Wee, Perlyn Zekui Kwek, Sin Yin Chew, Jianhe Peng, Liling Wu, Ernesto Guccione, Joma Joy, Jeffrey Hill
4 Feb 2017 BMRC Experimental Drug Development Centre Screening for a Potent Antibacterial Peptide to Treat Mupirocin- Resistant MRSA Skin Infections Siew Mei Samantha Ng, Hui Si Vivian Ching, GuiFang Xu, Fui Mee Ng, Esther H. Q. Ong, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, C. S. Brian Chia
19 Jan 2017 BMRC Experimental Drug Development Centre Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans Yi Yong Alvin Yap, Timothy Barkham, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Siew Mei Samantha Ng, Jeanette Woon Pei Teo, Jeffrey Hill, C. S. Brian Chia
30 Jun 2016 BMRC Experimental Drug Development Centre Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhin Ying Poh, Shuang Liu, Siew Wen Then, Michelle Yueqi Lee, Hui Qi Ng, Qiwei Huang, Alvin W Hung, Joseph Cherian, Jeffrey Hill, Thomas H Keller, CongBao Kang
31 May 2016 BMRC Experimental Drug Development Centre Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease Anders Poulsen, John Liang Kuan Wee, Fui Mee Ng, Joma Joy, Jeffrey Hill, J. Y. Melgious Ang, C. S. Brian Chia, Huichang Annie Lim
24 Mar 2016 BMRC Experimental Drug Development Centre Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 & 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells Kassoum Nacro, Zhi Ying Poh, Samantha Guo, Joseph Cherian, Duraiswamy Jeyaraj, Yun Xuan Wong, Melvyn Ho, Hai Yan Yang, Joma Kanikadu Joy, Zekui Perlyn Kwek, Boping Liu, John Laing Kuan Wee Wee, Esther Hq Ong, Meng Ling Choong, Anders Poulsen, May Ann Lee, Vishal Pendharkar, Vithya Manoharan, Yun Shan Chew, Kanda Sangthongpitag, Sharon Lim, S. Tiong Ong, Jeffrey Hill, Thomas H. Keller
4 Nov 2015 BMRC Experimental Drug Development Centre Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor. Boping Liu, CongBao Kang, Yan Li, Joseph Cherian, Hui Qi Ng, Michelle Yueqi Lee, Nur Huda Ahmad, Zhi Ying Poh, Yun Xuan Wong, Qiwei Huang, Ying Lei Wong, Alvin Hung, Jeffrey Hill, Thomas Keller
17 Oct 2015 BMRC Experimental Drug Development Centre Characterization of the interaction between E. coli topoisomerase IV E subunit and an ATP competitive inhibitor. Thomas Hugo Keller, CongBao Kang, Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhi Ying Poh, Siew Wen Then, Michelle Lee, Hui Qi Ng, Alvin Hung, Joseph Cherian, Jeffrey Hill
9 Oct 2015 BMRC Experimental Drug Development Centre An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA). Qiu Ying Lau, Yoke Yan Fion Tan, Vanessa Chai Yin Goh, David Jing Qin Lee, Fui Mee Ng, Esther H. Q. Ong, Jeffrey Hill, Cheng San Brian Chia
10 Aug 2015 BMRC Experimental Drug Development Centre NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor. Yan Li, Yun Xuan Wong, Zhi Ying Poh, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, Boping Liu, Alvin Hung, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, CongBao Kang
10 Aug 2015 BMRC Experimental Drug Development Centre Wnt addiction of genetically defined cancers reversed by PORCN inhibition Babita Madan, Zhiyuan Ke, Nathan Harmston, Soo Yei Ho, Frois Ashley Oliver, Jenefer Alam, Duraiswamy Jeyaraj, Vishal Pendharkar, Kakaly Ghosh, Isaac H Virshup, Vithya Manoharan, Esther Hq Ong, Kanda Sangthongpitag, Jeffrey Hill, Enrico Petretto, Thomas Keller, May Ann Lee, Alex Matter, David M Virshup
24 Jun 2015 BMRC Experimental Drug Development Centre Application of Fragment-Based Drug Discovery against DNA Gyrase B Cheng San Brian Chia, Qiu Ying Lau, Jeffrey Hill, Alvin Hung, Thomas Keller, Siew Wen Then, Nur Huda Ahmad, Ying Lei Wong, Hui Qi Ng, Guo-Ying Chen, Fui Mee Ng, Yih Wan Tan, Anders Poulsen, Wei Guang Seetoh, Grace Lin, CongBao Kang
5 May 2015 BMRC Experimental Drug Development Centre Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria Horst Flotow, Jeffrey Hill, Ravikiran Raju, Wilfried Moreira, Grace Ngan, Jian Liang Low, Anders Poulsen, Brian Chia, Melgious Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim, Audrey Khoo, Eric Rubin, Thomas Dick
20 Mar 2015 BMRC Institute of Molecular and Cell Biology Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study Melgious J. Y. Ang, Qiu Ying Lau, Fui Mee Ng, Siew Wen Then, Anders Poulsen, Yuen Kuen Cheong, Zi Xian Ngoh, Yong Wah Tan, Jianhe Peng, Thomas H. Keller, Jeffrey Hill, Justin J. H. Chu, C. S. Brian Chia
7 Nov 2014 BMRC Experimental Drug Development Centre A Head-to-Head Comparison of the Antimicrobial Activities of 30 Ultra- Short Antimicrobial Peptides Against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans Qiu Ying Lau, Fui Mee Ng, Jeffrey Hill, Brian Chia
15 Oct 2014 SERC Institute of Chemical and Engineering Sciences 3-Deazaneplanocin A and Neplanocin A analogues and their effects on apoptotic cell death Eric K. W. Tam, Tuan Minh Nguyen, Cheryl Z. H. Lim, Puay Leng Lee, Zhimei Li, Xia Jiang, Sridhar Santhanakrishnan, Tiong Wei Tan, Yi Ling Goh, Sze Yue Wong, Haiyan Yang, Esther H. Q. Ong, Jeffrey Hill, Qiang Yu, Christina L. L. Chai
12 Oct 2014 SERC Institute of Chemical and Engineering Sciences Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core Christina L. L. Chai, Jin Xu, Esther H.Q. Ong, Jeffrey Hill, Anqi Chen
15 Jul 2014 BMRC Experimental Drug Development Centre Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques Xiaoying Koh-Stenta, Joma Joy, Anders Poulsen, Yvonne Tan, Anna Ngo, Jianhe Peng, Wei Guamg Seetoh, Jing Cao, John Liang Kuan Wee, Perlyn Zekui Kwek, Alvin Hung, Umayal Lakshmanan, Horst Flowtow, Jeffrey Hill
8 Aug 2013 SERC Institute of Chemical and Engineering Sciences Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor Vanessa Joanne Xavier, Jin Xu, Anqi Chen, Joma Joy, Esther H. Q. Ong, Jeffrey Hill, Christina L. L. Chai