The Singapore National Precision Medicine Strategy

The Singapore National Precision Medicine Strategy

Nature Genetics

10.1038/s41588-022-01274-x

http://dx.doi.org/10.1038/s41588-022-01274-x

Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin-Fang Chai, Jimmy Lee, Joseph Jao-Yiu Sung, Tien Yin Wong, Calvin Woon Loong Chin, Peter D. Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee Tan, , Rob M. van Dam, Yik Ying Teo, Marie Loh, Paul Eillot, Eng Sing Lee, Joanne Ngeow, Elio Riboli, Rinkoo Dalan, Irfahan Kassam, Lakshmi Narayanan Lakshmanan, Tock Han Lim, Hong Kiat Ng, Theresia Mina, Darwin Tay, Charumathi Sabanayagam, Yih Chung Tham, Tyler Rim, Tin Aung, Miao Ling Chee, Hengtong Li, Miao Li Chee, Khung Keong Yeo, Stuart Alexander Cook, Chee Jian Pua, Chengxi Yang, Yap Seng Chong, Johan Gunnar Eriksson, Kok Hian Tan, Fabian Yap, Chia Wei Lim, Pi Kuang Tsai, Wen Jie Chew, Wey Ching Sim, Li-xian Grace Toh, Clarabelle Bitong Lin, Yee Yen Sia, Tat Hung Koh, Wee Yang Meah, Joanna Hui Juan Tan, Justin Jeyakani, Jack Ow, Shimin Ang, Ashar J. Malik, Dimitar Kenanov, Xueling Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jianjun Liu, Shyam Prabhakar, Sebastian Maurer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C. Chambers, E. Shyong Tai, Patrick Tan

19 January 2023

Wong, E., Bertin, N., Hebrard, M., Tirado-Magallanes, R., Bellis, C., Lim, W. K., Chua, C. Y., Tong, P. M. L., Chua, R., Mak, K., Lim, T. M., Cheong, W. Y., Thien, K. E., Goh, K. T., Chai, J.-F., Lee, J., Sung, J. J.-Y., Wong, T. Y., Chin, C. W. L., … Tan, P. (2023). The Singapore National Precision Medicine Strategy. Nature Genetics, 55(2), 178–186. https://doi.org/10.1038/s41588-022-01274-x

Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world’s population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.

Publisher Copyright

This research / project is supported by the A*STAR - Industry Alignment Fund Pre-Positioning (IAF-PP)
Grant Reference no. : H17/01/a0/007

This research / project is supported by the National Medical Research Council - Singapore Translational Research Investigator Award
Grant Reference no. : NMRC/STaR/0028/2017

This research / project is supported by the ASTAR - Industry Alignment Fund Pre-Positioning (IAF-PP)
Grant Reference no. : H18/01/a0/016

This research / project is supported by the National Medical Research Council / Ministry of Health (MOH) - Translational and Clinical Research Flagship Program
Grant Reference no. : NMRC/TCR/004-NUS/2008

This research / project is supported by the National Medical Research Council / Ministry of Health (MOH) - Translational and Clinical Research (TCR) Flagship Program
Grant Reference no. : NMRC/TCR/012-NUHS/2014

This research / project is supported by the A*STAR - Industry Alignment Fund Pre-Positioning (IAF-PP)
Grant Reference no. : H17/01/a0/005

This research / project is supported by the National Medical Research Council - Clinician Scientist Individual Research Grant
Grant Reference no. : NMRC/CIRG/1417/2015

This research / project is supported by the National Medical Research Council - Clinician Scientist Individual Research Grant
Grant Reference no. : NMRC/CIRG/1488/2018

This research / project is supported by the National Medical Research Council - Open Fund Large Collaborative Grant
Grant Reference no. : NMRC/OFLCG/004/2018

This research / project is supported by the Ministry of Health (MOH) / National Medical Research Council - Individual research and clinical scientist award
Grant Reference no. : MOH-000271-00

This research / project is supported by the National Medical Research Council - Centre Grant
Grant Reference no. : NMRC/CG/M006/2017_NHCS

This research / project is supported by the National Medical Research Council - Singapore Translational Research Investigator Award
Grant Reference no. : NMRC/STaR/0011/2012

This research / project is supported by the National Medical Research Council - Singapore Translational Research Investigator Award
Grant Reference no. : NMRC/STaR/0026/2015

This research / project is supported by the National Medical Research Council - Centre Grant
Grant Reference no. : NMRC/CG12AUG2017

This research / project is supported by the National Medical Research Council - Centre Grant
Grant Reference no. : CGAug16M012

This research / project is supported by the Ministry of Health (MOH) - National Precision Medicine Program (NPM) Phase II
Grant Reference no. : MOH-000588

This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41588-022-01274-x

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