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7 May 2021
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Riemannian Similarity Learning
|
Cheng Li
|
|
11 Jan 2021
|
Identification of pathways modulating vemurafenib resistance in melanoma cells via a genome-wide CRISPR/Cas9 screen
|
Corinna Jie Hui Goh,
Jin Huei Wong,
Chadi El Farran,
Ban Xiong Tan,
Cynthia R. Coffill,
Yuin-Hain Loh,
David Lane,
Prakash Arumugam
|
|
29 Sep 2020
|
Structural Modelling of the Lumenal Domain of Human GPAA1, the Metallo-Peptide Synthetase Subunit of the Transamidase Complex, Reveals Zinc-Binding Mode and Two Flaps Surrounding the Active Site
|
Tran-To Su Su,
Swati Sinha,
Birgit Eisenhaber,
Frank Eisenhaber
|
|
12 Sep 2020
|
Disorder driven allosteric control of protein activity
|
Wei-Ven Tee,
Enrico Guarnera,
Igor N Berezovsky
|
|
9 Sep 2020
|
Virtual screening of potentially endocrine‑disrupting chemicals against nuclear receptors and its application to identify PPARγ‑bound fatty acids
|
Chaitanya K Jaladanki,
Yang He,
Li Na Zhao,
Sebastian Maurer-Stroh,
Lit-Hsin Loo,
Haiwei Song,
Hao Fan
|
|
3 Sep 2020
|
Augmented Reality in scientific visualization and communications: A new dawn of looking at antibody interactions
|
Samuel Ken-En Gan,
Kwok-Fong Chan,
Jun-Jie Poh,
Wei-Ling Wu
|
|
1 Sep 2020
|
Critical role for cold shock protein YB-1 in cytokinesis
|
Antony Braithwaite,
Sunali Mehta,
Michael Algie,
Tariq Al-Jabry,
Cushla McKinney,
Srinivasaraghavan Kannan,
Chandra S Verma,
Weini Ma,
Jessie Zhang,
Tara K Bartolec,
V. Pragathi Masamsetti,
Kim Parker,
Luke Henderson,
Maree L Gould,
Puja Bhatia,
Rhodri Harfoot,
Megan Chircop,
Torsten Kleffmann,
Scott B Cohen,
Adele G Woolley,
Anthony J Cesare
|
|
18 Aug 2020
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Straightforward incorporation of multiple ligand types into molecular dynamics simulations for efficient binding site detection and characterization
|
Yaw Sing Tan,
Chandra S Verma
|
|
13 Aug 2020
|
Accelerated spin dynamics using deep learning corrections
|
Sojeong Park,
Wooseop Kwak,
Hwee Kuan Lee
|
|
29 Jun 2020
|
Optimum concentration-response curve metrics for supervised selection of discriminative cellular phenotypic endpoints for chemical hazard assessment
|
James A Miller
|
|
11 May 2020
|
Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability
|
Srinivasaraghavan Kannan,
Pietro G. A. Aronica,
Simon Ng,
Dawn Thean Gek Lian,
Yuri Frosi,
Sharon Chee,
Shimin Jiang,
Tsz Ying Yuen,
Ahmad Sadruddin,
Hung Yi Kristal Kaan,
Arun Chandramohan,
Yi Han,
Jin Huei Wong,
Yaw Sing Tan,
Zi Wei Chang,
Fernando Jose Ferrer-Gago,
Prakash Arumugam,
Shiying Chen,
Laurent Claude Stephane Renia,
Christopher J. Brown,
Charles W. Johannes,
Brian Henry,
David P. Lane,
Tomi K Sawyer,
Chandra S. Verma,
Anthony William Patridge
|
|
11 May 2020
|
AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations
|
Zhen Wah Tan,
Enrico Guarnera,
Wei-Ven Tan,
Igor N. Berezovsky
|
|
10 May 2020
|
Extending the Martini coarse-grained forcefield to N-glycans
|
Aishwary T. Shivgan,
Jan K. Marzinek,
Roland G. Huber,
Alexander Krah,
Richard H. Henchman,
Paul Matsudaira,
Chandra S. Verma,
Peter J. Bond
|
|
5 May 2020
|
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits
|
Simon Ng,
Yu-Chi Juang,
Arun Chandramohan,
Hung Yi Kristal Kaan,
Ahmad Sadruddin,
Tsz Ying Yuen,
Fernando J. Ferrer-Gago,
Xue'Er Cheryl Lee,
Liew Xi,
Charles W. Johanes,
Christopher J. Brown,
Srinivasaraghavan Kanan,
Pietro G. Aronica,
Nils A. Berglund,
Chandra S. Verma,
Lijuan Liu,
Alexander Stoeck,
Tomi K. Sawyer,
Anthony W. Partridge,
David P. Lane
|
|
29 Apr 2020
|
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
|
Li Ren Kong,
Richard Weijie Ong,
Tua Zea Tan,
Nur Afiqah Binte Mohamed Salleh,
Matan Thangavelu,
Jane Vin Chan,
Lie Yong Judice Koh,
Giridharan Periyasamy,
Jieying Amelia Lau,
Thi Bich Uyen Le,
Lingzhi Wang,
Miyoung Lee,
Srinivasaraghavan Kannan,
Chandra S. Verma,
Chwee Ming Lim,
Wee Joo Chng,
David P. Lane,
Ashok Venkitaraman,
Huynh The Hung,
Chit Fang Cheok,
Boon Cher Goh
|
|
24 Apr 2020
|
Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes
|
Jianguo Li,
Roger Beuerman,
Chandra S. Verma
|
|
24 Apr 2020
|
Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)
|
James Chun Yip Chan,
Stephanie Chupin,
Lei Zhou,
Naïg Gueguen,
Valérie Desquiret-Dumas,
Siew Kwan Koh,
Jianguo Li,
Yao Gan,
Lu Deng,
Chandra Verma,
Roger W. Beuerman,
Dan Milea,
Eric Chun Yong Chan Chan,
Pascal Reynier
|
|
23 Apr 2020
|
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop
|
Ruth A. Roberts,
Thomas Steger-Hartmann,
Evita Vanenbossche,
Mark R. Viant,
Matthieu Vinken,
Maurice Whelan,
Zvonar Zvonimir,
Mark T. D. Cronin,
Catherine Mahony,
Randolph S. Ashton,
Barbara Birk,
Alan R. Boobis,
Tom Cull,
George P. Daston,
Lorna Ewart,
Thomas B. Knudsen,
Irene Manou,
Sebastian Maurer-Stroh,
Luigi Margiotta-Casaluci,
Boris P. Muller,
Pär Nordlund
|
|
21 Apr 2020
|
Directed Computational Evolution of Quorum-Quenching Lactonases from the Amidohydrolase Superfamily
|
Maybelle Kho Kho,
Lin Na Zhao,
Bo Xue,
Shreyas Supekar,
Robert C. Robinson,
Hao Fan,
Wen Shan Yew
|
|
18 Apr 2020
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Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
|
Wei-Li Ling,
Wai-Heng Lua,
Samuel Ken-En Gan
|
|
5 Apr 2020
|
A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins
|
Lorena Zuzic,
Jan K. Marzinek,
Jim Warwicker,
Peter J. Bond
|
|
4 Apr 2020
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Probability of change in life: Amino acid changes in single nucleotide substitutions
|
Kwok-Fong Chan,
Stelios Koukouravas,
Joshua Yi Yeo,
Darius Wen-Shuo Koh,
Ken-En Samuel Gan
|
|
25 Mar 2020
|
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
|
Nur Afiqah Binte Mohamed Salleh,
Richard Weijie Ong,
Li Ren Kong,
Tuan Zea Tan,
Nicholas L. Syn,
Robby Miguel Goh,
Chee Wai Fhu,
Daniel S W Tan,
Gopalakrishna Iyer,
Srinivasaraghavan Kannan,
Chandra S. Verma,
Yaw Chyn Lim,
Ross Soo,
Jingshan Ho,
Yiqing Huang,
Joline S. J. Lim,
Benedict Junrong Yan,
Min En Nga,
Seng Gee Lim,
H. Philip Koeffler,
Soo Chin Lee,
Dennis Kappei,
Huyhn The Hung,
Boon Cher Goh
|
|
19 Mar 2020
|
Identification and engineering of 32 membered antifungal macrolactone notonesomycins
|
Falicia Goh,
Mingzi M. Zhang,
Tian Ru Lim,
Kia Ngee Low,
Choy Eng Nge,
Elena Heng,
Wan Lin Yeo,
Fernanda L. Sirota,
Sharon Crasta,
Zann Tan,
Veronica Ng,
Chung Yan Leong,
Hubin Zhang,
Alexander Lezhava,
Swaine L. Chen,
Shawn S. Hoon,
Frank Eisenhaber,
Birgit Eisenhaber,
Yoganathan Kanagasundaram,
Fong T. Wong,
Siew Bee Ng
|
|
16 Mar 2020
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Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures
|
Rachel Pung,
Calvin J. Chiew,
Barnaby E. Young,
Sarah Chin,
Mark I-C Chen,
Hannah E. Clapham,
Alex R. Cook,
Sebastian Maurer-Stroh,
Matthias P. H. S Toh,
Cuiqin Poh,
Mabel Low,
Joshua Lum,
Valerie T. J. Koh,
Tze M. Mak,
Lin Cui,
Raymond V. T. P Lin,
Derrick Heng,
Yee-Sin Leo,
David C. Lye,
Vernon J. M. Lee
|
|
9 Mar 2020
|
The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance
|
Joshua Yi Yeo,
Ghin-Ray Goh,
Chinh Tran-To Su,
Samuel Ken-En Gan
|
|
3 Mar 2020
|
How Ligand Binding Affects the Dynamical Transition Temperature in Proteins
|
Alexander Krah,
Roland G. Huber,
Peter J. Bond
|
|
28 Feb 2020
|
Viruses go modular
|
Ariel Shepley-McTaggart,
Hao Fan,
Marius Sudol,
Ronald N. Harty
|
|
27 Feb 2020
|
Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020
|
Noppavan Janejai,
Pilailuk Okada,
Rome Buathong,
Siripaporn Phuygun,
Thanutsapa Thanadachakul,
Sittiporn Parnmen,
Warawan Wongboot,
Sunthareeya Waicharoen,
Supaporn Wacharapluesadee,
Sumonmal Uttayamakul,
Apichart Vachiraphan,
Malinee Chittaganpitch,
Nanthawan Mekha,
Sopon Iamsirithaworn,
Raphael T. C. Lee,
Sebastian Maurer-Stroh
|
|
14 Feb 2020
|
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
|
Youwen Zhuang,
Heng Liu,
X Edward Zhou,
Ravi Kumar Verma,
Parker W. de Waal,
Wonjo Jang,
Ting-Hai Xu,
Lei Wang,
Xing Meng,
Gongpu Zhao,
Yanyong Kang,
Karsten Melcher,
Hao Fan,
Nevin A. Lambert,
H. Eric Xu,
Cheng Zhang
|
|
12 Feb 2020
|
Allosteric drugs and mutations: chances, challenges, and necessity
|
Enrico Guarnera,
Igor N. Berezovsky
|
|
12 Feb 2020
|
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
|
Firdaus Samsudin,
Joshua Yi Yeo,
Samuel Ken-En Gan,
Peter J. Bond
|
|
11 Feb 2020
|
A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health
|
Leo T. M. van der Ven,
Emiel Rorije,
R. Connie Sprong,
Daniele Zink,
Remco Derr,
Giel Hendriks,
Lit-Hsin Loo,
Mirjam Luijten
|
|
7 Feb 2020
|
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products
|
Jitka Petrolova,
Ganna Petruk,
Roland G. Huber,
Eilish W. McBurnie,
Mariena J. A. van der Plas,
Peter J. Bond,
Manoj Puthia,
Artur Schmidtchen
|
|
7 Feb 2020
|
Machine-Learning Studies on Spin Models
|
Kenta Shiina,
Hiroyuki Mori,
Yutaka Okabe,
Hwee-Kuan Lee
|
|
25 Jan 2020
|
Multiscale modelling and simulation of viruses
|
Jan K. Marzinek,
Roland G. Huber,
Peter J. Bond
|
|
6 Jan 2020
|
Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding
|
Hao Fan,
Sachdev S. Sidhu,
Ziying Han,
Shantoshini Dash,
Cari A. Sagum,
Gordon Ruthel,
Chaitanya K. Jaladanki,
Corbett T. Berry,
Michael P. Schwoerer,
Nina M. Harty,
Bruce D. Freedman,
Mark T. Bedford,
Marius Sudol,
Olena Shtanko,
Ronald N. Harty
|
|
24 Dec 2019
|
Flavivirus Cross-Reactivity to Dengue Nonstructural Protein 1 Antigen Detection Assays
|
Li Kiang Tan,
Wing Yan Wong,
Hui Ting Yang,
Roland G. Huber,
Peter J. Bond,
Lee Ching Ng,
Sebastian Maurer-Stroh,
Hapuarachchige Chanditha Hapuarachchi
|
|
12 Dec 2019
|
In Memory of Vladimir B. Bajic (1952–2019)
|
Zhang Zhang,
Jun Yu,
Frank Eisenhaber,
Xin Gao,
Takashi Gojobori
|
|
10 Dec 2019
|
Quantum scale biomimicry of low dimensional growth: An unusual complex amorphous precursor route to TiO2 band confinement by shape adaptive biopolymer-like flexibility for energy applications
|
Dahyun Choi,
Sanjiv Sonkaria,
Stephen J. Fox,
Shivraj Poudel,
Sung-yong Kim,
Suhee Kang,
Seheon Kim,
Chandra S. Verma,
Sung Hoon Ahn,
Caroline Sunyong Lee,
Varsha Khare
|
|
6 Dec 2019
|
Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition
|
Dilraj Lama,
Chandra S. Verma
|
|
1 Dec 2019
|
New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation
|
Justin L. Tan,
Feng Li,
Joanna Z. Yeo,
Kol Jia Yong,
Mahmoud A. Bassal,
Guo Hao Ng,
May Yin Lee,
Chung Yan Leong,
Hong Kee Tan,
Chan-shuo Wu,
Bee Hui Liu,
Tim H. Chan,
Zi Hui Tan,
Yun Shen Chan,
Siyu Wang,
Zhi Han Lim,
Tan Boon Toh,
Lissa Hooi,
Kia Ngee Low,
Siming Ma,
Nikki R. Kong,
Alicia J. Stein,
Yue Wu,
Matan T. Thangavelu,
Atsushi Suzuki,
Giridharan Periyasamy,
John M. Asara,
Yock Young Dan,
Glenn K. Bonney,
Edward K. Chow,
Guo-Dong Lu,
Huck Hui Ng,
Yoganathan Kanagasundaram,
Siew Bee Ng,
Wai Leong Tam,
Daniel G. Tenen,
Li Chai
|
|
28 Nov 2019
|
The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
|
Srinivasaraghavan Kannan,
Anthony W. Partridge,
David P. Lane,
Chandra S. Verma
|
|
28 Nov 2019
|
On the ion coupling mechanism of the MATE transporter ClbM
|
Alexander Krah,
Roland G. Huber,
Ulrich Zachariae,
Peter J. Bond
|
|
25 Nov 2019
|
G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action
|
Stacy Gelhaus Wendell,
Hao Fan,
Cheng Zhang
|
|
13 Nov 2019
|
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
|
Joanna Niska-Blakie,
Lakshmi Gopinathan,
Kia Ngee Low,
Yang Lay Kien,
Christine M. F. Goh,
Matias J. Caldez,
Elisabeth Pfeiffenberger,
Oliver S. Jones,
Chee Bing Ong,
Igor V. Kurochkin,
Vincenzo Coppola,
Lino Tessarollo,
Hyungwon Choi,
Yoganathan Kanagasundaram,
Frank Eisenhaber,
Sebastian Maurer-Stroh,
Philipp Kaldis
|
|
11 Nov 2019
|
Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1
|
Umesh Kalathiya,
Monikaben Padariya,
Kamila Pawlicka,
Chandra S. Verma,
Douglas Houston,
Ted R. Hupp,
Javier Antonio Alfaro
|
|
1 Nov 2019
|
The quantification of antibody elements and receptors subunit expression using qPCR: The design of VH, VL, CH, CL, FcR subunits primers for a more holistic view of the immune system
|
Wei-Li Ling,
Yuen-Ling Ng,
Anil Wipat,
David Philip Lane,
Samuel Ken-En Gan
|
|
10 Oct 2019
|
Linker length affects photostability of protein-targeted sensor of cellular microviscosity
|
Markéta Kubánková,
Joseph E. Chambers,
Roland G. Huber,
Peter J. Bond,
Stefan J. Marciniak,
Marina K. Kuimova
|
|
9 Oct 2019
|
Inferring putative transmission clusters with Phydelity
|
Alvin X. Han,
Edyth Parker,
Sebastian Maurer-Stroh,
Colin A. Russell
|