Ubiquitination Defect of X-Linked Inhibitor of Apoptosis Protein as a Novel Susceptibility to Invasive Fungal Pneumonia

Ubiquitination Defect of X-Linked Inhibitor of Apoptosis Protein as a Novel Susceptibility to Invasive Fungal Pneumonia

The Journal of Infectious Diseases

10.1093/infdis/jiag272

https://doi.org/10.1093/infdis/jiag272

Rachel Ying Min Tan, Zhi Xiong Chen, J Sivaraman, Kiat Whye Kong, Zhaohong Tan, Shengli Xu, Jin Zhu, Paul Anantharajah Tambyah, Yiqi Seow, Winston Koh, Ban Hock Tan, Louis Yi Ann Chai

26 May 2026

Tan, R. Y. M., Chen, Z. X., Sivaraman, J., Kong, K. W., Tan, Z., Xu, S., Zhu, J., Tambyah, P. A., Seow, Y., Koh, W., Tan, B. H., & Chai, L. Y. A. (2026). Ubiquitination Defect of X-Linked Inhibitor of Apoptosis Protein as a Novel Susceptibility to Invasive Fungal Pneumonia. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiag272

Programmed cell death and systematic protein degradation as exemplified by apoptosis and ubiquitination, respectively, are essential biological processes for homeostasis and cellular regeneration. We show that dysregulated ubiquitination and aggravated apoptosis resulting from hypomorphic X-linked inhibitor of apoptosis protein gene mutation suppressed innate immunity, predisposing to human invasive fungal pneumonia.

Publisher Copyright

Collaboration with NUHS

This research / project is supported by the National Research Foundation - Competitive Research Programme
Grant Reference no. : NA

This research / project is supported by the National Medical Research Council, Singapore Ministry of Health - Clinical Scientist Award (CSASI)
Grant Reference no. : NA

This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Infectious Diseases following peer review. The version of record Tan, R. Y. M., Chen, Z. X., Sivaraman, J., Kong, K. W., Tan, Z., Xu, S., Zhu, J., Tambyah, P. A., Seow, Y., Koh, W., Tan, B. H., & Chai, L. Y. A. (2026). Ubiquitination Defect of X-Linked Inhibitor of Apoptosis Protein as a Novel Susceptibility to Invasive Fungal Pneumonia. The Journal of Infectious Diseases. is available online at: https://doi.org/10.1093/infdis/jiag272

https://oar.a-star.edu.sg/communities-collections/articles/22717

1537-6613
0022-1899

Bioinformatics Institute