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10 May 2020
|
BMRC
|
Bioinformatics Institute
|
Extending the Martini coarse-grained forcefield to N-glycans
|
Aishwary T. Shivgan,
Jan K. Marzinek,
Roland G. Huber,
Alexander Krah,
Richard H. Henchman,
Paul Matsudaira,
Chandra S. Verma,
Peter J. Bond
|
bioRxiv
|
|
5 Apr 2020
|
BMRC
|
Bioinformatics Institute
|
A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins
|
Lorena Zuzic,
Jan K. Marzinek,
Jim Warwicker,
Peter J. Bond
|
bioRxiv
|
|
3 Mar 2020
|
BMRC
|
Bioinformatics Institute
|
How Ligand Binding Affects the Dynamical Transition Temperature in Proteins
|
Alexander Krah,
Roland G. Huber,
Peter J. Bond
|
ChemPhysChem
|
|
12 Feb 2020
|
BMRC
|
Bioinformatics Institute
|
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
|
Firdaus Samsudin,
Joshua Yi Yeo,
Samuel Ken-En Gan,
Peter J. Bond
|
Chemical Science
|
|
7 Feb 2020
|
BMRC
|
Bioinformatics Institute
|
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products
|
Jitka Petrolova,
Ganna Petruk,
Roland G. Huber,
Eilish W. McBurnie,
Mariena J. A. van der Plas,
Peter J. Bond,
Manoj Puthia,
Artur Schmidtchen
|
Journal of Biological Chemistry
|
|
25 Jan 2020
|
BMRC
|
Bioinformatics Institute
|
Multiscale modelling and simulation of viruses
|
Jan K. Marzinek,
Roland G. Huber,
Peter J. Bond
|
Current Opinion in Structural Biology
|
|
24 Dec 2019
|
BMRC
|
Bioinformatics Institute
|
Flavivirus Cross-Reactivity to Dengue Nonstructural Protein 1 Antigen Detection Assays
|
Li Kiang Tan,
Wing Yan Wong,
Hui Ting Yang,
Roland G. Huber,
Peter J. Bond,
Lee Ching Ng,
Sebastian Maurer-Stroh,
Hapuarachchige Chanditha Hapuarachchi
|
Diagnostics
|
|
28 Nov 2019
|
BMRC
|
Bioinformatics Institute
|
On the ion coupling mechanism of the MATE transporter ClbM
|
Alexander Krah,
Roland G. Huber,
Ulrich Zachariae,
Peter J. Bond
|
Biochimica et Biophysica Acta (BBA) - Biomembranes
|
|
10 Oct 2019
|
BMRC
|
Bioinformatics Institute
|
Linker length affects photostability of protein-targeted sensor of cellular microviscosity
|
Markéta Kubánková,
Joseph E. Chambers,
Roland G. Huber,
Peter J. Bond,
Stefan J. Marciniak,
Marina K. Kuimova
|
Methods and Applications in Fluorescence
|
|
19 Sep 2019
|
BMRC
|
Bioinformatics Institute
|
Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C
|
Xin-Ni Lim,
Chao Shan,
Jan K. Marzinek,
Hongping Dong,
Thiam Seng Ng,
Justing S. G. Ooi,
Guntur Fibrianshah,
Jiaqi Wang,
Chandra S. Verma,
Peter J. Bond,
Pei-Yong Shi,
Shee-Mei Lok
|
PLOS Pathogens
|
|
27 Aug 2019
|
BMRC
|
Bioinformatics Institute
|
The structural basis for membrane assembly of immunoreceptor signalling complexes
|
Namita Dube,
Jan K. Marzinek,
Robert C. Glen,
Peter J. Bond
|
Journal of Molecular Modeling
|
|
24 Jul 2019
|
BMRC
|
Bioinformatics Institute
|
Multiscale modeling of innate immune receptors: Endotoxin recognition and regulation by host defense peptides
|
Daniel A. Holdbrook,
Roland G. Huber,
Jan K. Marzinek,
Astrid Stubbusch,
Artur Schmitchen,
Peter J. Bond
|
Pharmacological Research
|
|
26 Jun 2019
|
BMRC
|
Bioinformatics Institute
|
A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice
|
Kitti Wing Ki Chan,
Satoru Watanabe,
Jocelyn Y. Jin,
Julien Pompon,
Don Teng,
Sylvie Alonso,
Dhanasekaran Vijaykrishna,
Scott B. Halstead,
Jan K. Marzinek,
Peter J. Bond,
Bo Burla,
Federico Torta,
Markus R. Wenk,
Eng Eong Ooi,
Subhash G. Vasudevan
|
Science Translational Medicine
|
|
24 May 2019
|
BMRC
|
Bioinformatics Institute
|
Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ
|
Neelagandan Kamariah,
Roland G. Huber,
Wilson Nartey,
Shashi Bhushan,
Peter J. Bond,
Gerard Gruber
|
Journal of Structural Biology
|
|
29 Mar 2019
|
BMRC
|
Bioinformatics Institute
|
Structure mapping of dengue and Zika viruses reveals functional long-range interactions
|
Roland G. Huber,
Xin Ni Lim,
Wy Ching Ng,
Adelene Y. L. Sim,
Hui Xian Poh,
Yang Shen,
Su Ying Lim,
Karin B. Sundstrom,
Xuyang Sun,
Jong Ghut Aw,
Horng Khit Too,
Peng Hee Boey,
Andreas Wilm,
Tanu Chawla,
Milly M. Choy,
Lu Jiang,
Paola Florez De Sessions,
Xian Jun Loh,
Sylvie Alonso,
Martin Hibberd,
Niranjan Nagarajan,
Eng Eong Ooi,
Peter J. Bond,
October M. Sessions,
Wan Yue
|
Nature Communications
|
|
1 Mar 2019
|
BMRC
|
Bioinformatics Institute
|
Insights into water accessible pathways and the inactivation mechanism of proton translocation by the membrane-embedded domain of V-type ATPases
|
Alexander Krah,
Jan K. Marzinek,
Peter J. Bond
|
Biochimica et Biophysica Acta (BBA) - Biomembranes
|
|
28 Feb 2019
|
BMRC
|
Bioinformatics Institute
|
The disordered plant dehydrin Lti30 protects the membrane during water-related stress by cross-linking lipids
|
Anjali Gupta,
Jan K. Marzinek,
Damien Jefferies,
Peter J. Bond,
Pia Harryson,
Thorsten Wohland
|
Journal of Biological Chemistry
|
|
24 Jan 2019
|
BMRC
|
Bioinformatics Institute
|
Infectivity of Dengue Virus Serotypes 1 and 2 Is Correlated with E-Protein Intrinsic Dynamics but Not to Envelope Conformations
|
Kamal Kant Sharma,
Xin-Xiang Lim,
Sarala Neomi Tantirimudalige,
Anjali Gupta,
Jan K. Marzinek,
Daniel Holdbrook,
Xin Ying Elisa Lim,
Peter J. Bond,
Ganesh S. Anand,
Thorsten Wohland
|
Structure
|
|
4 Jan 2019
|
BMRC
|
Bioinformatics Institute
|
Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics
|
Shuting Cai,
Daniel H. Lukamto,
Jerry K. C. Toh,
Roland G. Huber,
Peter J. Bond,
Joo-Eun Jee,
Teck Chuan Lim,
Pei Liu,
Liwei Chen,
Qianqian Vicky Qu,
Su Seong Lee,
Song-Gil Lee
|
Chemical Communications
|
|
29 Nov 2018
|
BMRC
|
Bioinformatics Institute
|
Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices
|
Madhubrata Ghosh,
Loo Chien Wang,
Roland G. Huber,
Yufeng Gao,
Leslie K. Morgan,
Nikhil Kumar Tulsian,
Peter J. Bond,
Linda J. Kenney,
Ganesh S. Anand
|
Structure
|
|
21 Nov 2018
|
BMRC
|
Bioinformatics Institute
|
Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody
|
Melissa Wirawan,
Guntur Fibriansah,
Jan K. Marzinek,
Xin Xiang Lim,
Thiam Seng Ng,
Adelene Y. L. Sim,
Qian Zhang,
Victor A. Kostyuchenko,
Jian Shi,
Scott A. Smith,
Chandra S. Verma,
Ganesh Anand,
James E. Crowe Jr,
Peter J. Bond,
Shee-Mei Lok
|
Structure
|
|
21 Nov 2018
|
BMRC
|
Bioinformatics Institute
|
Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody
|
Melissa Wirawan,
Guntur Fibriansah,
Jan K. Marzinek,
Xin Xiang Lim,
Thiam-Seng Ng,
Adelene Y. L. Sim,
Qian Zhang,
Victor A. Kostyuchenko,
Jian Shi,
Scott A. Smith,
Chandra S. Verma,
Ganesh Anand,
James E. Jr Crowe,
Peter J. Bond,
Shee-Mei Lok
|
Structure
|
|
14 Sep 2018
|
BMRC
|
Bioinformatics Institute
|
Single-molecule studies of flavivirus envelope dynamics: Experiment and computation
|
Kamal Kant Sharma,
Jan K. Marzinek,
Sarala Neomi Tantirimudalige,
Peter J. Bond,
Thorsten Wohland
|
Progress in Biophysics and Molecular Biology
|
|
5 Sep 2018
|
BMRC
|
Bioinformatics Institute
|
Single mutations in the ε subunit from thermophilic Bacillus PS3 generate a high binding affinity site for ATP
|
Alexander Krah,
Peter J. Bond
|
PeerJ
|
|
24 Aug 2018
|
BMRC
|
Bioinformatics Institute
|
Facile saccharide-free mimetics that recapitulate key features of glycosaminoglycan sulfation patterns
|
Song-Gil Lee,
Teck Chuan Lim,
Shuting Cai,
Roland G. Huber,
Peter J. Bond,
Priscilla Xian Siew Chia,
Siv Ly Khou,
Shujun Gao,
Su Seong Lee
|
Chemical Science
|
|
20 Jul 2018
|
BMRC
|
Bioinformatics Institute
|
The architecture of the OmpC-MlaA complex sheds light on the maintenance of outer membrane lipid asymmetry in Escherichia coli
|
Jiang Yeow,
Kang Wei Tan,
Daniel A. Holdbrook,
Zhi-Soon Chong,
Jan K. Marzinek,
Peter J. Bond,
Shu-Sin Chng
|
Journal of Biological Chemistry
|
|
17 Jul 2018
|
BMRC
|
Bioinformatics Institute
|
Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides
|
Rathi Saravanan,
Daniel A. Holdbrook,
Jitka Petrlova,
Shalini Singh,
Nils A. Berglund,
Yeu Khai Choong,
Sven Kjellstrom,
Peter J. Bond,
Martin Malmsten,
Artur Schmidtchen
|
Nature Communications
|
|
6 Jun 2018
|
BMRC
|
Bioinformatics Institute
|
Influence of pH on the activity of thrombin-derived antimicrobial peptides
|
Daniel A. Holdbrook,
Shalini Singh,
Yeu Khai Choong,
Jitka Petrlova,
Martin Malmsten,
Peter J. Bond,
Navin Kumar Verma,
Artur Schmidtchen,
Rathi Saravanan
|
Biochimica et Biophysica Acta (BBA) - Biomembranes
|
|
17 May 2018
|
BMRC
|
Bioinformatics Institute
|
A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway
|
Roland G. Huber,
Nils A. Berglund,
Vasileios Kargas,
Jan K. Marzinek,
Daniel A. Holdbrook,
Syma Khalid,
Thomas J. Piggot,
Artur Schmidtchen,
Peter J. Bond
|
Structure
|
|
19 Apr 2018
|
BMRC
|
Bioinformatics Institute
|
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
|
Graeme I. Lancaster,
Katherine G. Langley,
Nils Anton Berglund,
Helene L. Kammoun,
Saskia Reibe,
Emma Estevez,
Jacquelyn Weir,
Natalie A. Mellett,
Gerard Pernes,
James R.W. Conway,
Man K.S. Lee,
Paul Timpson,
Andrew J. Murphy,
Seth L. Masters,
Steve Gerondakis,
Nenad Bartonicek,
Dominik C. Kaczorowski,
Marcel E. Dinger,
Peter J. Meikle,
Peter J. Bond,
Mark A. Febbraio
|
Cell Metabolism
|
|
12 Apr 2018
|
BMRC
|
Bioinformatics Institute
|
An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles
|
Joseph E. Chambers,
Markéta Kubánková,
Roland G. Huber,
Ismael López-Duarte,
Edward Avezov,
Peter J. Bond,
Stefan J. Marciniak,
Marina K. Kuimova
|
ACS Nano
|
|
6 Dec 2016
|
BMRC
|
Bioinformatics Institute
|
OmpA: A Flexible Clamp for Bacterial Cell Wall Attachment
|
Firdaus Samsudin,
Maite L. Ortiz-Suarez,
Thomas J. Piggot,
Peter J. Bond,
Syma Khalid
|
Structure
|
|
1 Nov 2016
|
BMRC
|
Bioinformatics Institute
|
Energetics and Dynamics Across the Bcl-2-Regulated Apoptotic Pathway Reveal Distinct Evolutionary Determinants of Specificity and Affinity
|
Roland G. Huber,
Stefan M. Ivanov,
Jim Warwicker,
Peter J. Bond
|
Structure
|
|
1 Nov 2016
|
BMRC
|
Bioinformatics Institute
|
Hydrocarbons Are Essential for Optimal Cell Size, Division, and Growth of Cyanobacteria
|
David J. Lea-Smith,
Maite L. Ortiz-Suarez,
Tchern Lenn,
Dennis J. Nürnberg,
Laura L. Baers,
Matthew P. Davey,
Lucia Parolini,
Roland G. Huber,
Charles A. R. Cotton,
Giulia Mastroianni,
Paolo Bombelli,
Petra Ungerer,
Tim J. Stevens,
Alison G. Smith,
Peter J. Bond,
Conrad W. Mullineaux,
Christopher J. Howe
|
Plant Physiology
|
|
18 Oct 2016
|
BMRC
|
Bioinformatics Institute
|
Full-Length OmpA: Structure, Function, and Membrane Interactions Predicted by Molecular Dynamics Simulations
|
Maite L. Ortiz-Suarez,
Firdaus Samsudin,
Thomas J. Piggot,
Peter J. Bond,
Syma Khalid
|
Biophysical Journal
|
|
29 Sep 2016
|
BMRC
|
Bioinformatics Institute
|
Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function
|
Roland G. Huber,
Irina Kulemzina,
Keven Ang,
Alap P. Chavda,
Sasikala Suranthran,
Jun-Thing Teh,
Dimitar Kenanov,
Gaowen Liu,
Giulia Rancati,
Radoslaw Szmyd,
Philipp Kaldis,
Peter J. Bond,
Dmitri Ivanov
|
Structure
|
|
10 Aug 2016
|
BMRC
|
Bioinformatics Institute
|
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6
|
Yu Fukuda,
Pak Leng Cheong,
John Lynch,
Cheryl Brighton,
Sharon Frase,
Vasileios Kargas,
Evadnie Rampersaud,
Yao Wang,
Vijay G. Sankaran,
Bing Yu,
Paul A. Ney,
Mitchell J. Weiss,
Peter Vogel,
Peter J. Bond,
Robert C. Ford,
Ronald J. Trent,
John D. Schuetz
|
Nature Communications
|
|
7 Jul 2016
|
BMRC
|
Bioinformatics Institute
|
Pushing the Envelope: Dengue Viral Membrane Coaxed into Shape by Molecular Simulations
|
Jan K. Marzinek,
Daniel A. Holdbrook,
Roland G. Huber,
Chandra Verma,
Peter J. Bond
|
Structure
|
|
16 Jun 2016
|
BMRC
|
Bioinformatics Institute
|
Dynamics of Crowded Vesicles: Local and Global Responses to Membrane Composition
|
Daniel A. Holdbrook,
Roland G. Huber,
Thomas J. Piggot,
Peter J. Bond,
Syma Khalid
|
PLOS ONE
|
|
27 May 2016
|
BMRC
|
Bioinformatics Institute
|
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications
|
Amy Cording,
Michael Gormally,
Peter J. Bond,
Mark Carrington,
Shankar Balasubramanian,
Eric A. Miska,
Beth Thomas
|
RNA Biology
|
|
20 Jan 2016
|
BMRC
|
Bioinformatics Institute
|
Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment
|
Jan K. Marzinek,
Rajamani Lakshminarayanan,
Eunice Goh,
Roland G. Huber,
Sadhana Panzade,
Chandra Verma,
Peter J. Bond
|
Scientific Reports
|