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9 Sep 2020 BMRC Bioinformatics Institute Virtual screening of potentially endocrine‑disrupting chemicals against nuclear receptors and its application to identify PPARγ‑bound fatty acids Chaitanya K Jaladanki, Yang He, Li Na Zhao, Sebastian Maurer-Stroh, Lit-Hsin Loo, Haiwei Song, Hao Fan Archives of Toxicology
23 Apr 2020 BMRC Bioinformatics Institute New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop Ruth A. Roberts, Thomas Steger-Hartmann, Evita Vanenbossche, Mark R. Viant, Matthieu Vinken, Maurice Whelan, Zvonar Zvonimir, Mark T. D. Cronin, Catherine Mahony, Randolph S. Ashton, Barbara Birk, Alan R. Boobis, Tom Cull, George P. Daston, Lorna Ewart, Thomas B. Knudsen, Irene Manou, Sebastian Maurer-Stroh, Luigi Margiotta-Casaluci, Boris P. Muller, Pär Nordlund Regulatory Toxicology and Pharmacology
16 Mar 2020 BMRC Bioinformatics Institute Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures Rachel Pung, Calvin J. Chiew, Barnaby E. Young, Sarah Chin, Mark I-C Chen, Hannah E. Clapham, Alex R. Cook, Sebastian Maurer-Stroh, Matthias P. H. S Toh, Cuiqin Poh, Mabel Low, Joshua Lum, Valerie T. J. Koh, Tze M. Mak, Lin Cui, Raymond V. T. P Lin, Derrick Heng, Yee-Sin Leo, David C. Lye, Vernon J. M. Lee The Lancet
27 Feb 2020 BMRC Bioinformatics Institute Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020 Noppavan Janejai, Pilailuk Okada, Rome Buathong, Siripaporn Phuygun, Thanutsapa Thanadachakul, Sittiporn Parnmen, Warawan Wongboot, Sunthareeya Waicharoen, Supaporn Wacharapluesadee, Sumonmal Uttayamakul, Apichart Vachiraphan, Malinee Chittaganpitch, Nanthawan Mekha, Sopon Iamsirithaworn, Raphael T. C. Lee, Sebastian Maurer-Stroh Eurosurveillance
24 Dec 2019 BMRC Bioinformatics Institute Flavivirus Cross-Reactivity to Dengue Nonstructural Protein 1 Antigen Detection Assays Li Kiang Tan, Wing Yan Wong, Hui Ting Yang, Roland G. Huber, Peter J. Bond, Lee Ching Ng, Sebastian Maurer-Stroh, Hapuarachchige Chanditha Hapuarachchi Diagnostics
13 Nov 2019 BMRC Bioinformatics Institute Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M. F. Goh, Matias J. Caldez, Elisabeth Pfeiffenberger, Oliver S. Jones, Chee Bing Ong, Igor V. Kurochkin, Vincenzo Coppola, Lino Tessarollo, Hyungwon Choi, Yoganathan Kanagasundaram, Frank Eisenhaber, Sebastian Maurer-Stroh, Philipp Kaldis Cellular and Molecular Life Sciences
9 Oct 2019 BMRC Bioinformatics Institute Inferring putative transmission clusters with Phydelity Alvin X. Han, Edyth Parker, Sebastian Maurer-Stroh, Colin A. Russell Virus Evolution
17 Sep 2019 BMRC Bioinformatics Institute Rare Human Missense Variants can affect the Function of Disease-Relevant Proteins by Loss and Gain of Peroxisomal Targeting Motifs Cheng-Shoong Chong, Markus Kunze, Bernhard Hochreiter, Martin Krenn, Johannes Berger, Sebastian Maurer-Stroh International Journal of Molecular Sciences
22 Aug 2019 BMRC Bioinformatics Institute Influenza A Hemagglutinin Passage Bias Sites and Host Specificity Mutations Raphael T. C. Lee, Hsiao-Han Chang, Colin A. Russell, Marc Lipsitch, Sebastian Maurer-Stroh Cells
15 Aug 2019 BMRC Bioinformatics Institute Intense interseasonal influenza outbreaks, Australia, 2018/19 Ian G. Barr, Yi Mo Deng, Miguel L. Grau, Alvin X. Han, Robin Gilmour, Melissa Irwin, Peter Markey, Kevin Freeman, Geoff Higgins, Mark Turra, Naomi Komadina, Heidi Peck, Robert Booy, Sebastian Maurer-Stroh, Vijaykrishna Dhanasekaran, Sheena Sullivan Eurosurveillance
30 Jun 2019 BMRC Bioinformatics Institute Influenza passaging annotations: what they tell us and why we should listen Cory D. DuPai, Claire D. McWhite, Catherine B. Smith, Rebecca Garten, Sebastian Maurer-Stroh, Claus O. Wilke Virus Evolution
5 Jun 2019 BMRC Bioinformatics Institute Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity Theresa Enkirch, Svenja Sauber, Danielle E. Anderson, Esther S. Gan, Dimitar Kenanov, Sebastian Maurer-Stroh, Veronika von Messling Frontiers in Immunology
8 Apr 2019 BMRC Bioinformatics Institute A novel method for the capture-based purification of whole viral native RNA genomes Cedric Chih Shen Tan Tan, Sebastian Maurer-Stroh, Yue Wan, October Michael Sessions, Paola Florez de Sessions AMB Express
23 Mar 2019 BMRC Bioinformatics Institute Proteomic and Bioinformatic Analyses for the Identification of Proteins With Low Allergenic Potential for Hazard Assessment Nora L. Krutz, Jason Winget, Cindy A. Ryan, Rohan Wimalasena, Sebastian Maurer-Stroh, Rebecca J. Dearman, Ian Kimber, G. Frank Gerberick Toxicological Sciences
22 Mar 2019 BMRC Bioinformatics Institute Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism Francesca Napoletano, Miguel Mano, Rebecca Bertolio, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal Nature Communications
11 Mar 2019 BMRC Bioinformatics Institute Phylogenetic Clustering by Linear Integer Programming (PhyCLIP) Alvin X. Han, Edyth Parker, Frits Scholer, Sebastian Maurer-Stroh, Colin A. Russell Molecular Biology and Evolution
18 Jan 2019 BMRC Bioinformatics Institute AllerCatPro - Prediction of protein allergenicity potential from the protein sequence Sebastian Maurer-Stroh, Nora L. Krutz, Petra S. Kern, Vithiagaran Gunalan, Minh N. Nguyen, Vachiranee Limviphuvadh, Frank Eisenhaber, G. Frank Gerberick Bioinformatics
1 Jan 2019 BMRC Bioinformatics Institute Supervised Segmentation of Un-Annotated Retinal Fundus Images by Synthesis He Zhao, Huiqi Li, Sebastian Maurer-Stroh, Yuhong Guo, Qiuju Deng, Li Cheng IEEE Transactions in Medical Imaging
3 Dec 2018 BMRC Bioinformatics Institute Individual immune selection pressure has limited impact on seasonal influenza virus evolution Alvin X. Han, Sebastian Maurer-Stroh, Colin A. Russell Nature Ecology & Evolution
27 Nov 2018 BMRC Bioinformatics Institute The Geographic Variation of Surveillance and Zoonotic Spillover Potential of Influenza Viruses in Domestic Poultry and Swine Kathryn A. Berger, David M. Pigott, Francesca Tomlinson, David Godding, Sebastian Maurer-Stroh, Biruhalem Taye, Fernanda L. Sirota, Alvin Han, Raphael T. C. Lee, Vithiagaran Gunalan, Frank Eisenhaber, Simon I. Hay, Colin A. Russell Open Forum Infectious Diseases
24 Oct 2018 BMRC Bioinformatics Institute Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure Vipin Narang, Yanxia Lu, Crystal Tan, Xavier F. N. Camous, Shwe Zin Nyunt, Christopher Carre, Esther Wing Hei Mok, Glenn Wong, Sebastian Maurer-Stroh, Brian Abel, Nicolas Burdin, Michael Poidinger, Paul Anantharajah Tambyah, Nabil Bosco, Lucian Visan, Tze Pin Ng, Anis Larbi Frontiers in Immunology
4 Jul 2018 BMRC Bioinformatics Institute Synthesizing retinal and neuronal images with generative adversarial nets He Zhao, Huiqi Li, Sebastian Maurer-Stroh, Li Cheng Medical Image Analysis
3 Jul 2018 BMRC Bioinformatics Institute Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017. Angie Lackenby, Terry G. Besselaar, Rod S. Daniels, Alicia Fry, Vicki Gregory, Larisa V. Gubareva, Weijuan Huang, Aeron C. Hurt, Sook-Kwan Leang, Raphael T. C. Lee, Janice Lo, Lori Lollis, Sebastian Maurer-Stroh, Takato Odagiri, Dmitriy Pereyaslov, Emi Takashita, Dayan Wang, Wenqing Zhang, Adam Meijer Antiviral Research
30 May 2018 BMRC Bioinformatics Institute Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes Manuela Pigors, John E. A. Common, Xuan Fei Colin C. Wong, Sajid Malik, Claire A. Scott, Niloofar Tabarra, Herty Liany, Jianjun Liu, Vachiranee Limviphuvadh, Nicholas Lench, Sebastian Maurer-Stroh, Mark B. Y. Tang, David J. Margolis, David A. van Heel, Charles A. Mein, Natalija Novak, Hansjorg Baurecht, Stephan Weidinger, W. H. Irwin McLean, Alan D. Irvine, Edel A. O'Toole, Michael A. Simpson, David P. Kelsell Journal of Investigative Dermatology
30 May 2018 BMRC Bioinformatics Institute Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes Manuela Pigors, John E. A. Common, Xuan Fei Colin C. Wong, Sajid Malik, Claire A. Scott, Niloofar Tabarra, Herty Liany, Jianjun Liu, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Mark B. Y. Tang, Nicholas Lench, David J. Margolis, David A. van Heel, Charles A. Mein, Natalija Novak, Hansjorg Baurecht, Stephan Weidinger, Erwin W. H. McLean, Alan D. Irvine, Edel A. O'Toole, Michael A. Simpson, David P. Kelsell Journal of Investigative Dermatology
11 May 2018 BMRC Bioinformatics Institute Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy Vachiranee Limviphuvadh, Chee Seng Tan, Fumikazu Konishi, Piroon Jenjaroenpun, Joy Shengnan Xiang, Yuliya Kremenska, Yar Soe Mu, Syn Nicholas, Lee Soo Chin, Ross A. Soo, Frank Eisenhaber, Sebastian Maurer-Stroh, Wei Peng Yong BMC Cancer
11 Nov 2016 BMRC Bioinformatics Institute Viral factors in influenza pandemic risk assessment Marc Lipsitch, Wendy Barclay, Rahul Raman, Charles J Russell, Jessica A Belser, Sarah Cobey, Peter M Kasson, James O Lloyd-Smith, Sebastian Maurer-Stroh, Steven Riley, Catherine AA Beauchemin, Trevor Bedford, Thomas C Friedrich, Andreas Handel, Sander Herfst, Pablo R Murcia, Benjamin Roche, Claus O Wilke, Colin A Russell eLife
22 Sep 2016 BMRC Bioinformatics Institute South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016 Sebastian Maurer-Stroh, Tze-Minn Mak, Yi-Kai Ng, Shiau-Pheng Phuah, Roland G Huber, Jan K Marzinek, Daniel A Holdbrook, Raphael TC Lee, Lin Cui, Raymond TP Lin Eurosurveillance
13 Sep 2016 BMRC Bioinformatics Institute Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice Andrei V. Tkatchenko, Xiaoyan Luo, Tatiana V. Tkatchenko, Candida Vaz, Vivek M. Tanavde, Sebastian Maurer-Stroh, Stefan Zauscher, Pedro Gonzalez, Terri L. Young PLOS ONE
7 Sep 2016 BMRC Bioinformatics Institute Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years’ History of H3N2 Influenza Evolution Hui Chen, Qiang Deng, Sock Hoon Ng, Raphael Tze Chuen Lee, Sebastian Maurer-Stroh, Weiwei Zhai Molecular Biology and Evolution
25 Aug 2016 BMRC Bioinformatics Institute Molecular and biochemical characterization of the NS1 protein of non-cultured influenza B virus strains circulating in Singapore Muhammad Raihan Jumat, Puisan Wong, Raphael Tze Chuen Lee, Sebastian Maurer-Stroh, Boon Huan Tan, Richard J. Sugrue Microbial Genomics
1 Jul 2016 BMRC Bioinformatics Institute Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Tomokazu Souma, Stuart W. Tompson, Benjamin R. Thomson, Owen M. Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, Vachiranee Limviphuvadh, Kristina N. Whisenhunt, Sebastian Maurer-Stroh, Tammy L. Yanovitch, Luba Kalaydjieva, Dimitar N. Azmanov, Simone Finzi, Lucia Mauri, Shahrbanou Javadiyan, Emmanuelle Souzeau, Tiger Zhou, Alex W. Hewitt, Bethany Kloss, Kathryn P. Burdon, David A. Mackey, Keri F. Allen, Jonathan B. Ruddle, Sing-Hui Lim, Steve Rozen, Khanh-Nhat Tran-Viet, Xiaorong Liu, Simon John, Janey L. Wiggs, Francesca Pasutto, Jamie E. Craig, Jing Jin, Susan E. Quaggin, Terri L. Young Journal of Clinical Investigation
3 Jun 2016 BMRC Bioinformatics Institute Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015 Aeron C. Hurt, Terry G. Besselaar, Rod S. Daniels, Burcu Ermetal, Alicia Fry, Larisa Gubareva, Weijuan Huang, Angie Lackenby, Raphael T.C. Lee, Janice Lo, Sebastian Maurer-Stroh, Ha T. Nguyen, Dmitriy Pereyaslov, Helena Rebelo-de-Andrade, Marilda M. Siqueira, Emi Takashita, Masato Tashiro, Danielle Tilmanis, Dayan Wang, Wenqing Zhang, Adam Meijer Antiviral Research
24 Mar 2016 BMRC Bioinformatics Institute HIV-1 adaptation to low levels of CCR5 results in V3 and V2 loop changes that increase envelope pathogenicity, CCR5 affinity and decrease susceptibility to Maraviroc Himanshu Garg, Raphael T.C. Lee, Sebastian Maurer-Stroh, Anjali Joshi Virology
4 Mar 2016 BMRC Bioinformatics Institute Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission Hapuarachchige Chanditha Hapuarachchi, Carmen Koo, Relus Kek, Helen Xu, Yee Ling Lai, Lilac Liu, Suet Yheng Kok, Yuan Shi, Raphael Lee Tze Chuen, Kim-Sung Lee, Sebastian Maurer-Stroh, Lee Ching Ng Scientific Reports
15 Jan 2016 BMRC Bioinformatics Institute Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance Keng Boon Wee, Raphael Tze Chuen Lee, Jing Lin, Zacharias Aloysius Dwi Pramono, Sebastian Maurer-Stroh PLOS Computational Biology
16 Jan 2015 BMRC Bioinformatics Institute The contrasting phylodynamics of human influenza B viruses Udayan Joseph, Dhanasekaran Vijaykrishna, Edward C Holmes, Mathieu Fourment, Yvonne CF Su, Rebecca Halpin, Raphael TC Lee, Yi-Mo Deng, Vithiagaran Gunalan, Xudong Lin, Timothy B Stockwell, Nadia B Fedorova, Bin Zhou, Natalie Spirason, Denise Kühnert, Veronika Bošková, Tanja Stadler, Anna-Maria Costa, Dominic E Dwyer, Q Sue Huang, Lance C Jennings, William Rawlinson, Sheena G Sullivan, Aeron C Hurt, Sebastian Maurer-Stroh, David E Wentworth, Gavin JD Smith, Ian G Barr eLife
23 Dec 2014 BMRC Bioinformatics Institute Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: THE CO-RECEPTOR PEX5L DRASTICALLY INCREASES THE INTERACTION STRENGTH BETWEEN THE CARGO PROTEIN AND THE RECEPTOR PEX7 Sebastian Maurer-Stroh, Christoph Wiesinger, Johannes A. Schmid, Johannes Berger, Markus Kunze, Naila Malkani Journal of Biological Chemistry
18 Dec 2014 BMRC Bioinformatics Institute Emergence of norovirus GI.2 outbreaks in military camps in Singapore Zheng Jie Marc Ho, Gunalan Vithia, Ching Ging Ng, Sebastian Maurer-Stroh, Clive M. Tan, Jimmy Loh, Tzer Pin Raymond Lin, Jian Ming Vernon Lee International Journal of Infectious Diseases
10 Dec 2014 BMRC Bioinformatics Institute Adaptation of Pandemic H2N2 Influenza A Viruses in Humans Udayan Joseph, Martin Linster, Yuka Suzuki, Scott Krauss, Rebecca A. Halpin, Dhanasekaran Vijaykrishna, Thomas P. Fabrizio, Theo M. Bestebroer, Sebastian Maurer-Stroh, Richard J. Webby, David E. Wentworth, Ron A. M. Fouchier, Justin Bahl, Gavin J. D. Smith Journal of Virology
8 Dec 2014 BMRC Bioinformatics Institute Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients Tzia Liang Mah, Xin Ning Adeline Yap, Vachiranee Limviphuvadh, Nanpu Li, Srinath Sridharan, Vellaisemy Kuralmani, Mengling Feng, Natalia Liem, Sharmila Adhikari, Wei Peng Yong, Ross A Soo, Sebastian Maurer-Stroh, Frank Eisenhaber, Joo Chuan Tong BMC Genomics
3 Nov 2014 BMRC Bioinformatics Institute Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks Julia Ponomarenko, Kerrie Vaughan, Alessandro Sette, Sebastian Maurer-Stroh PLoS Currents
16 Oct 2014 BMRC Bioinformatics Institute Improving pandemic influenza risk assessment Colin A Russell, Peter M Kasson, Ruben O Donis, Steven Riley, John Dunbar, Andrew Rambaut, Jason Asher, Stephen Burke, C Todd Davis, Rebecca J Garten, Sandrasegaram Gnanakaran, Simon I Hay, Sander Herfst, Nicola S Lewis, James O Lloyd-Smith, Catherine A Macken, Sebastian Maurer-Stroh, Elizabeth Neuhaus, Colin R Parrish, Kim M Pepin, Samuel S Shepard, David L Smith, David L Suarez, Susan C Trock, Marc-Alain Widdowson, Dylan B George, Marc Lipsitch, Jesse D Bloom eLife
12 Sep 2014 BMRC Bioinformatics Institute Recognizing flu-like symptoms from videos Sebastian Maurer-Stroh, Li Cheng, Tuan Hue Thi, Li Wang, Ning Ye, Jian Zhang BMC Bioinformatics
18 Jul 2014 BMRC Institute of Molecular and Cell Biology Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers Lawrence S. Lee, Jenny G.H. Low, Eng Eong Ooi, Kantharaj Ethirajulu, Pauline Yeo, Alex Matter, John E. Connolly, David A.G. Skibinski, Philippe Saudan, Martin Bachmann, Brendon J. Hanson, Qingshu Lu, Sebastian Maurer-Stroh, Sam Lim, Veronica Novotny-Diermayr Vaccine
6 May 2014 BMRC Bioinformatics Institute Detection of Evolutionarily Distinct Avian Influenza A Viruses in Antarctica Gonzalo Medina-Vogel, Bjorn Olsen, Anne Kelso, Ian G. Barr, Daniel Gonzalez-Acuna, Aeron C. Hurt, Dhanasekaran Vijaykrishna, Jeffrey Butler, Chantal Baas, Sebastian Maurer-Stroh, M. Carolina Silva-de-la-Fuente MBio
3 Apr 2014 BMRC Bioinformatics Institute Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses Jesse D. Bloom, Aeron C. Hurt, Kathryn A. Hooper, Jeff Butler, Stephen Petrie, Raphael Lee, Sebastian Maurer-Stroh, Lucia Reh, Teagan Guarnaccia, Chantal Baas, Lumin Xue, Sophie Vitesnik, Sook-Kwan Leang, Jodie McVernon, Anne Kelso, Ian G. Barr, James M. McCaw PLoS Pathogens
14 Mar 2014 BMRC Bioinformatics Institute Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection Yi-Mo Deng, Vithiagaran Gunalan, Sebastian Maurer-Stroh, Patrick C. Reading, Michelle D. Tate, Emma R. Job Viruses
10 Dec 2013 BMRC Bioinformatics Institute Automatic phylogenetic classification of bacterial beta-lactamase sequences including structural and antibiotic substrate preference information Jianmin Ma, Frank Eisenhaber, Sebastian Maurer-Stroh Journal of Bioinformatics and Computational Biology
2 Dec 2013 BMRC Bioinformatics Institute A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads Sebastian Maurer-Stroh, Vithiagaran Gunalan, Wing-Cheong Wong, Frank Eisenhaber Journal of Bioinformatics and Computational Biology