Sathasivam, T., Kai, J., Sugiarto, S., Yu, Y., Soo, D. X. Y., Zhu, Q., Merzaban, J., & Kai, D. (2023). Nano‐Strategies for Lignin Biomaterials toward Cancer Therapy. Advanced Healthcare Materials. Portico. https://doi.org/10.1002/adhm.202300024
Abstract:
Lignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area-to-volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the ASTAR - Career Development Award
Grant Reference no. : CDA202D800033
Description:
This is the peer reviewed version of the following article: Sathasivam, T., Kai, J., Sugiarto, S., Yu, Y., Soo, D. X. Y., Zhu, Q., Merzaban, J., & Kai, D. (2023). Nano‐Strategies for Lignin Biomaterials toward Cancer Therapy. Advanced Healthcare Materials. Portico. https://doi.org/10.1002/adhm.202300024, which has been published in final form at doi.org/10.1002/adhm.202300024. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.