Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters

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Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters
Title:
Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters
Journal Title:
Microchimica Acta
Publication Date:
11 October 2022
Citation:
Bu, Y., Yin, R., Yu, L., Su, P., Li, Z., Ye, E., Loh, X. J., Zhu, H., & Wang, S. (2022). Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters. Microchimica Acta, 189(11). https://doi.org/10.1007/s00604-022-05509-w
Abstract:
An enhanced ratiometric fluorescence sensor was built for on-site visual detection of doxycycline (DOX) through the interaction with bovine serum albumin on the surface of red emissive copper nanoclusters. Upon the addition of weakly fluorescent DOX, the red fluorescence from copper nanoclusters gradually decreased through the inner-filter effect (IFE), while a green fluorescence appears and significantly increases, forming an interesting fluorescent isosbestic point, which was assigned to DOX due to sensitization effect of bovine serum albumin. On the basis of this ratiometric fluorescence, the system possessed good limit of detection (LOD) of 45 nM and excellent selectivity for DOX over other tetracyclines. Based on these findings, a paper-based sensor has been fabricated for distinct visual detection of trace DOX and combined with smartphone color recognizer for quantitative detection of DOX (LOD = 83 nM). This method shows broad application prospects in environmental monitoring and food safety.
License type:
Publisher Copyright
Funding Info:
This work was supported by the National Natural Science Foundation of China (U21A20290, 82001957), the Guangdong Basic and Applied Basic Research Foundation (2022A1515011656).
Description:
This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00604-022-05509-w
ISSN:
1436-5073
0026-3672
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