Institute of Molecular and Cell Biology

Publication date Article title Author(s)
25 Apr 2021 Functional Comparison of Interferon‐α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon‐α and Interferon‐γ Signaling Jieliang Chen, Yaming Li, Fritz Lai, Yang Wang, Kathrin Sutter, Ulf Dittmer, Jianyu Ye, Wenjing Zai, Min Liu, Fang Shen, Min Wu, Kongying Hu, Baocun Li, Mengji Lu, Xiaonan Zhang, Jiming Zhang, Jianhua Li, Qingfeng Chen, Zhenghong Yuan
25 Mar 2021 Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione
18 Mar 2021 Analysis and validation of human targets and treatments using a hepatocellular carcinoma‐immune humanized mouse model Yue Zhao, Jiaxu Wang, Wai Nam Liu, Shin Yie Fong, Timothy Wai Ho Shuen, Min Liu, Sarah Harden, Sue Yee Tan, Jia Ying Cheng, Wilson Wei Sheng Tan, Jerry Kok Yen Chan, Cheng Ean Chee, Guan Huei Lee, Han Chong Toh, Seng Gee Lim, Yue Wan, Qingfeng Chen
1 Mar 2021 sORF-Encoded MicroPeptides: New players in inflammation, metabolism, and precision medicine Ying Chen, Lena Ho, Vinay Tergaonkar
19 Feb 2021 Establishment of Humanized Mice for the Study of HBV Fritz Lai, Cherry Yong Yi Wee, Qingfeng Chen
28 Jan 2021 Exometabolomic Analysis of Decidualizing Human Endometrial Stromal and Perivascular Cells Sarah Louise Harden, Jieliang Zhou, Seley Gharanei, Maria Diniz-da-Costa, Emma S. Lucas, Liang Cui, Keisuke Murakami, Jinling Fang, Qingfeng Chen, Jan J. Brosens, Yie Hou Lee
26 Jan 2021 A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis Si Hui Tan, Phyllis Phuah, Liang Thing Tan, Swathi Yada, Jasmine Goh, Lucian B. Tomaz, Magdalene Chua, Esther Wong, Bernett Lee, Nick Barker
26 Jan 2021 A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells Kazuhiro Murakami, Yumi Terakado, Kikue Saito, Yoshie Jomen, Haruna Takeda, Masanobu Oshima, Nick Barker
22 Dec 2020 Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation Carly Leung, Katzrin Bte Ahmad Murad, Adelyn Liang Thing Tan, Swathi Yada, Sowmya Sagiraju, Peter Karl Bode, Nicholas Barker
21 Dec 2020 Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division Jin Rong Ow, Matias J Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyungwon Choi, Philipp Kaldis
25 Nov 2020 NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis Semih Can AKINCILAR, LeLe Wu, Qin Feng NG, Joelle Yi Heng Chua, Bilal Unal, Taichi Noda, Wei Hong Jeff Chor, Masahito Ikawa, Vinay Tergaonkar
4 Nov 2020 Loss of hepatocyte cell division leads to liver inflammation and fibrosis Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis
15 Oct 2020 Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics Kylie Su Mei Yong, Zhisheng Her, Sue Yee Tan, Wilson Wei Sheng Tan, Min Liu, Fritz Lai, Shi Min Heng, Yong Fan, Kenneth Tou En Chang, Cheng-I Wang, Jerry Kok Yen Chan, Jianzhu Chen, Qingfeng Chen
11 Sep 2020 CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice Zhisheng Her, Joel Heng Loong Tan, Yee-Siang Lim, Sue Yee Tan, Xue Ying Chan, Wilson Wei Sheng Tan, Min Liu, Kylie Su Mei Yong, Fritz Lai, Erica Ceccarello, Zhiqiang Zheng, Yong Fan, Kenneth Tou En Chang, Lei Sun, Shih Chieh Chang, Chih-Liang Chin, Guan Huei Lee, Yock Young Dan, Yun-Shen Chan, Seng Gee Lim, Jerry Kok Yen Chan, K. George Chandy, Qingfeng Chen
31 Jul 2020 ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization Hiu Yan Lam, Surendar Arumugam, Han Gyu Bae, Cheng Chun Wang, Sangyong Jung, Ashley Lauren St. John, Wanjin Hong, Weiping Han, Vinay Tergaonkar
22 Jul 2020 Small Molecule NF-κB Pathway Inhibitors in Clinic Venkataramanan Ramadass, Thamilselvan Vaiyapuri, NRF-CRP17-2017-02 Tergaonkar
17 Jul 2020 Global translation during early development depends on the essential transcription factor PRDM10 Brenda Y. Han, Michelle K.Y. Seah, Imogen R. Brooks, Delia H.P. Quek, Dominic R. Huxley, Chuan-Sheng Foo, Li Ting Lee, Heike Wollmann, Huili Guo, Daniel M. Messerschmidt, Ernesto Guccione
18 May 2020 BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells Larry Sai Weng Loo, Andreas Alvin Purnomo Soetedjo, Hwee Hui Lau, Natasha Hui Jin Ng, Soumita Ghosh, Linh Nguyen, Vidhya Gomathi Krishnan, Hyungwon Choi, Xavier Roca, Shawn Hoon, Adrian Kee Keong Teo
22 Apr 2020 Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy Wilson Wei Sheng Tan, Sue Yee Tan, Wai Nam Liu, Shin Yie Fong, Min Liu, Jia Ying Cheng, Sherlly Lim, Lisda Suteja, Edwin Kunxiang Huang, Jerry Kok Yen Chan, Narayanan Gopalakrishna Iyer, Joe Poh Sheng Yeong, Darren Wan-Teck Lim, Qingfeng Chen
16 Apr 2020 Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia Joel H. L. Tan, Heike Wollmann, Ans M.M. van Pelt, Philipp Kaldis, Daniel M. Messerschmidt
16 Apr 2020 IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice Wei-Xiang Sin, Joe Poh-Sheng Yeong, Thomas Jun Feng Lim, I-Hsin Su, John Edward Connolly, Keh-Chuang Chin
31 Mar 2020 Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies Kwang Seok Ahn, Hiu Yan Lam, Vinay Tergaonkar
13 Mar 2020 Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment - Winanto, Zi Jian Khong, Yong Fan, Boon Seng Soh, Shi-Yan Ng
13 Mar 2020 miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation Henry Yang, Giorgia Beffagna, Stefano Campanaro, Wai Leong Tam, Francesco Argenton, Lavanya Adusumilli, Nicola Facchinello, Cathleen Teh, Giorgia Busolin, Minh TN Le, Bing Lim, Vladimir Korzh, Natascia Tiso
11 Mar 2020 Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly Shan Zhang, Boris Reljić, Chao Liang, Baptiste Kerouanton, Joel Celio Francisco, Jih Hou Peh, Camille Mary, Narendra Suhas Jagannathan, Volodimir Olexiouk, Claire Tang, Gio Fidelito, Srikanth Nama, Ruey-Kuang Cheng, Caroline Lei Wee, Loo Chien Wang, Paula Duek Roggli, Prabha Sampath, Lydie Lane, Enrico Petretto, Radoslaw M. Sobota, Suresh Jesuthasan, Lisa Tucker-Kellogg, Bruno Reversade, Gerben Menschaert, Lei Sun, David A. Stroud, Lena Ho
9 Mar 2020 Therapeutics targeting the fibrinolytic system Haili Lin, Luning Xu, Shujuan Yu, Wanjin Hong, Mingdong Huang, Peng Xu
27 Feb 2020 Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation Belinda X. Ong, Reinhard Brunmeir, Qiongyi Zhang, Xu Peng, Muhammad Idris, Chungang Liu, Feng Xu
27 Feb 2020 Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation Belinda X. Ong, Reinhard Brunmeir, Qiongyi Zhang, Xu Peng, Muhammad Idris, Chungang Liu, Feng Xu
12 Feb 2020 Embryonic geometry underlies phenotypic variation in decanalized conditions Anqi Huang, Jean-François Rupprecht, Timothy E Saunders
11 Feb 2020 A new perspective of probe development for imaging pancreatic beta cell in vivo Claire Wen Ying Neo, Larissa Miasiro Ciaramicoli, Andreas Alvin Purnomo Soetedjo, Adrian Kee Keong Teo, Nam-Young Kang
10 Feb 2020 Multimodal Imaging Probe Development for Pancreatic β Cells: From Fluorescence to PET Nam-Young Kang, Jung Yeol Lee, Sang Hee Lee, In Ho Song, Yong Hwa Hwang, Min Jun Kim, Wut Hmone Phue, Bikram Keshari Agrawalla, Si Yan Diana Wan, Janise Lalic, Sung-Jin Park, Jong-Jin Kim, Haw-Young Kwon, So Hee Im, Myung Ae Bae, Jin Hee Ahn, Chang Siang Lim, Adrian Kee Keong Teo, Sunyou Park, Sang Eun Kim, Byung Chul Lee, Dong Yun Lee, Young-Tae Chang
3 Feb 2020 The mirtron miR-1010 functions in concert with its host gene SKIP to balance elevation of nAcRβ2 Christopher Amourda, Timothy E. Saunders
1 Feb 2020 AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells Maria L. Lotsberg, Katarzyna Wnuk-Lipinska, Stéphane Terry, Tuan Zea Tan, Ning Lu, Laura Trachsel-Moncho, Gro V. Røsland, Muntequa I. Siraji, Monica Hellesøy, Austin Rayford, Kirstine Jacobsen, Henrik J. Ditzel, Olav K. Vintermyr, Trever G. Bivona, John Minna, Rolf A. Brekken, Bruce Baguley, David Micklem, Lars A. Akslen, Gro Gausdal, Anne Simonsen, Jean Paul Thiery, Salem Chouaib, James B. Lorens, Agnete Svendsen Tenfjord Engelsen
30 Jan 2020 Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy Monica Yau, Nader Handal, Werner Deigendesch, Reinhard Keimer, Hiyam M. Marzouqa, Holger Hengel, Célia Bosso-Lefèvre, George Grady, Emmanuelle Szenker-Ravi, Hankun Li, Sarah Pierce, Élise Lebigot, Thong-Teck Tan, Michelle Y. Eio, Gunaseelan Narayanan, Kagistia Hana Utami, Meral Gunay-Aygun, Michael J. Muriello, Helene Verhelst, Sarah Weckhuysen, Sonal Mahida, Sakkubai Naidu, Terrence G. Thomas, Jiin Ying Lim, Ee Shien Tan, Damien Haye, Michèl A. A. P. Willemsen, Renske Oegema, Wendy G. Mitchell, Tyler Mark Pierson, Marisa V. Andrews, Marcia C. Willing, Lance H. Rodan, Tahsin Stefan Barakat, Marjon van Slegtenhorst, Ralitza H. Gavrilova, Diego Martinelli, Tal Gilboa, Abdullah M. Tamim, Mais O. Hashem, Moeenaldeen D. AlSayed, Maha M. Abdulrahim, Mohammed Al-Owain, Ali Awaji, Adel A. H. Mahmoud, Eissa A. Faqeih, Ali Al Asmari, Sulwan M. Algain, Lamyaa A. Jad, Hesham M. Aldhalaan, Ingo Helbig, David A. Koolen, Angelika Riess, Ingeborg Kraegeloh-Mann, Peter Bauer, Suleyman Gulsuner, Hannah Stamberger, Alvin Yu Jin Ng, Sha Tang, Sumanty Tohari, Boris Keren, Laura E. Schultz-Rogers, Eric W. Klee, Sabina Barresi, Marco Tartaglia, Hagar Mor-Shaked, Sateesh Maddirevula, Amber Begtrup, Aida Telegrafi, Rolph Pfundt, Rebecca Schüle, Brian Ciruna, Carine Bonnard, Mahmoud A. Pouladi, James C. Stewart, Adam Claridge-Chang, Dirk J. Lefeber, Fowzan S. Alkuraya, Bruno Reversade, Ajay S. Mathuru, Byrappa Venkatesh, Joseph J. Barycki, Melanie A. Simpson, Saumya S. Jamuar, Ludger Schöls
23 Jan 2020 Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris) Jay F. Storz, Chandrasekhar Natarajan, Magnus K. Grouleff, Michael Vandewege, Federico G. Hoffmann, Xinxin You, Byrappa Venkatesh, Angela Fago
10 Jan 2020 The RNA-binding protein HuR is a negative regulator in adipogenesis Diana Teh Chee Siang, Yen Ching Lim, Aung Maung Maung Kyaw, Khaing Nwe Win, Sook Yoong Chia, Ufuk Degirmenci, Xiang Hu, Bryan C. Tan, Arcinas Camille Esther Walet, Lei Sun, Dan Xu
10 Jan 2020 A Humanized Mouse Model to Study Mast Cells Mediated Cutaneous Adverse Drug Reactions Andrea Mencarelli, Merry Gunawan, Kylie Su Mei Yong, Pradeep Bist, Wilson Wei Sheng Tan, Sue Yee Tan, Min Liu, Edwin Kunxiang Huang, Yong Fan, Jerry Kok Yen Chan, Hae Woong Choi, Soman N. Abraham, Qingfeng Chen
10 Jan 2020 PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly Slim Mzoughi, Federico Di Tullio, Diana H. P. Low, Corina-Mihaela Motofeanu, Sheena L. M. Ong, Heike Wollmann, Cheng Mun Wun, Paul Kruszka, Maximilian Muenke, Friedhelm Hildebrandt, N. Ray Dunn, Daniel M. Messerschmidt, Ernesto Guccione
7 Jan 2020 Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease Yong Fan, Winanto, Shi-Yan Ng
3 Jan 2020 Candida albicans Ubiquitin and Heat Shock Factor-Type Transcriptional Factors Are Involved in 2-Dodecenoic Acid-Mediated Inhibition of Hyphal Growth Dongliang Yang, Yanling Hu, Zixin Yin, Qianru Gao, Yuqian Zhang, Fong Yee Chan, Guisheng Zeng, Lixing Weng, Lianhui Wang, Yue Wang
20 Dec 2019 PP2A-Like Protein Phosphatase (Sit4) Regulatory Subunits, Sap155 and Sap190, Regulate Candida albicans’ Cell Growth, Morphogenesis, and Virulence Jianli Sang, Qi Han, Chaoying Pan, Yueqing Wang, Linpeng Zhao, Yue Wang
18 Dec 2019 CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance Anette Langebäck, Smaranda Bacanu, Henriette Laursen, Lisanne Mout, Takahiro Seki, Sigrun Erkens-Schulze, Anderson Daniel Ramos, Anna Berggren, Yihai Cao, Johan Hartman, Wytske van Weerden, Jonas Bergh, Pär Nordlund, Sara Lööf
17 Dec 2019 Discovery of a chemical probe for PRDM9 Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
13 Dec 2019 Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong-Jae Shin, Do-Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar
11 Dec 2019 Dynamic proteome profiling of human pluripotent stem cellderived pancreatic progenitors Larry Sai Weng Loo, Heidrun Vethe, Andreas Alvin Purnomo Soetedjo, Joao A. Paulo, Joanita Jasmen, Nicholas Jackson, Yngvild Bjørlykke, Ivan A. Valdez, Marc Vaudel, Harald Barsnes, Steven P. Gygi, Helge Ræder, Adrian Kee Keong Teo, Rohit N. Kulkarni
3 Dec 2019 Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
29 Nov 2019 Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction Natalie Jia Ying Yeo, Ebenezer Jia Jun Chan, Christine Cheung
24 Nov 2019 The unusual di‐domain structure of Dunaliella salina glycerol‐3‐phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol Qinghua He, Joel Dewei Toh, Rya Ero, Zhu Qiao, Veerendra Kumar, Aida Serra, Jackie Tan, Siu Kwan Sze, Yong‐Gui Gao
19 Nov 2019 New insights into human beta cell biology using human pluripotent stem cells Nur Shabrina Amirruddin, Blaise Su Jun Low, Kok Onn Lee, E Shyong Tai, Adrian Kee Keong Teo
12 Nov 2019 Computational geometric tools for quantitative comparison of locomotory behavior Soo Go, Matthew T. Stamps, Ajay S. Mathuru