Zhu, H., Li, Z., Ye, E., & Leong, D. T. (2021). Oxygenic Enrichment in Hybrid Ruthenium Sulfide Nanoclusters for an Optimized Photothermal Effect. ACS Applied Materials Interfaces, 13(50), 60351–60361. https://doi.org/10.1021/acsami.1c17608
Abstract:
Transition metal dichalcogenide (TMD) based nanomaterials have been extensively explored for photonic therapy. To the best of our knowledge, near infrared light is the requirement for photothermal therapy to achieve the feature of deep-tissue penetration, whereas no obvious absorption peaks in the near-infrared (NIR) region for existing TMD nanomaterials limited their therapeutic efficacy. As one category of TMD nanomaterials, ruthenium sulfide based nanomaterials were less exploited in biomedical application including tumor therapy so far. Here we develop a facile biomineralization assisted bottom-up strategy to synthesize oxygenic hybrid ruthenium sulfide nanoclusters (RuSx NCs) with regulating oxygen amount and sulfur defects for optimized photothermal therapy (PTT). With regulating the increasing initial molar ratios of Ru to S, RuSx NCs with small sizes were endowed with ascending oxygen content and sulfur defect, leading to the photothermal conversion efficacy (PCE) from 32.8 % to 41.9 %, which were higher that of most small sized inorganic photothermal nanoagents. In contrast to the commercial ICG, such RuSx NCs exhibited higher photostability under NIR laser irradiation. The high PCE and superior photostability allowed RuSx NCs to effectively and completely ablate cancer cells. Thus, such defect engineering strategy facilitates RuSx NCs with excellent photothermal effect for PTT of tumor of living mice, also proved the potential to explore more property of RuSx NCs for future biomedical application.
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Funding Info:
This research / project is supported by the National Environment Agency - NA
Grant Reference no. : NA
This research / project is supported by the National Research Foundation - Competitive Research Program
Grant Reference no. : NRFCRP13-2014-03