Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes

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Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes
Title:
Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes
Other Titles:
ChemMedChem
Publication Date:
29 August 2021
Citation:
Yi, G., Riduan, S. N., Armugam, A., Ong, J. T., Hon, P. Y., Abdad, M. Y., Vasoo, S., Ang, B. S., & Zhang, Y. (2021). Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes. ChemMedChem, 16(23), 3553–3558. Portico. https://doi.org/10.1002/cmdc.202100504
Abstract:
In the search for a fast contact-killing antimicrobial surface to break the transmission pathway of lethal pathogens, nanostructured copper surfaces were found to exhibit the desired antimicrobial properties. Compared with plain copper, these nanostructured copper surfaces with Cu(OH)(2) nano-sword or CuO nano-foam were found to completely eliminate pathogens at a fast rate, including clinically isolated drug resistant species. Additionally these nanostructured copper surfaces demonstrated potential antiviral properties when assessed against bacteriophages, as a viral surrogate, and murine hepatitis virus, a surrogate for SARS-CoV-2. The multiple modes of killing, physical killing and copper ion mediated killing contribute to the superior and fast kinetics of antimicrobial action against common microbes, and ESKAPE pathogens. Prototypes for air and water cleaning with current nanostructured copper surface have also been demonstrated.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the National Research Foundation - NRF Competitive Research Program
Grant Reference no. : NRF-CRP19-2017-02

This research is supported by core funding from: A*STAR, Biomedical Research Council
Grant Reference no. :
Description:
This is the peer reviewed version of the following article: Yi, G., Riduan, S. N., Armugam, A., Ong, J. T., Hon, P. Y., Abdad, M. Y., Vasoo, S., Ang, B. S., & Zhang, Y. (2021). Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes. ChemMedChem, 16(23), 3553–3558. Portico. https://doi.org/10.1002/cmdc.202100504 ], which has been published in final form at doi.org/10.1002/cmdc.202100504. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited
ISSN:
1860-7179
1860-7187
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