Characterising Alzheimer‘s Disease with EEG-based Energy Landscape Analysis

Characterising Alzheimer‘s Disease with EEG-based Energy Landscape Analysis
Title:
Characterising Alzheimer‘s Disease with EEG-based Energy Landscape Analysis
Other Titles:
IEEE Journal of Biomedical and Health Informatics
Publication Date:
18 August 2021
Citation:
Klepl, D., He, F., Wu, M., De Marco, M., Blackburn, D., Sarrigiannis, P. G. (2021). Characterising Alzheimers Disease with EEG-based Energy Landscape Analysis. IEEE Journal of Biomedical and Health Informatics, 1–1. doi:10.1109/jbhi.2021.3105397
Abstract:
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, with around 50 million patients worldwide. Accessible and non-invasive methods of diagnosing and characterising AD are therefore urgently required. Electroencephalography (EEG) fulfils these criteria and is often used when studying AD. Several features derived from EEG were shown to predict AD with high accuracy, e.g. signal complexity and synchronisation. However, the dynamics of how the brain transitions between stable states have not been properly studied in the case of AD and EEG data. Energy landscape analysis is a method that can be used to quantify these dynamics. This work presents the first application of this method to both AD and EEG. Energy landscape assigns energy value to each possible state, i.e. pattern of activations across brain regions. The energy is inversely proportional to the probability of occurrence. By studying the features of energy landscapes of 20 AD patients and 20 healthy age-matched counterparts, significant differences were found. The dynamics of AD patients’ EEG were shown to be more constrained – with more local minima, less variation in basin size, and smaller basins. We show that energy landscapes can predict AD with high accuracy, performing significantly better than baseline models.
License type:
Publisher Copyright
Funding Info:
The original data collection was funded by a grant from the Alzheimer’s Research UK (ARUK-PPG20114B-25). The first author is supported by A*STAR Research Attachment Programme (ARAP).
Description:
© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
ISSN:
2168-2194
2168-2208
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