Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes

Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes
Title:
Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes
Other Titles:
Journal of Investigative Dermatology
DOI:
10.1016/j.jid.2018.05.013
Keywords:
Publication Date:
30 May 2018
Citation:
Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes Pigors, Manuela et al. Journal of Investigative Dermatology, Volume 138, Issue 12, 2674 - 2677
Abstract:
Atopic eczema (AE) is a heterogeneous chronic inflammatory skin condition that affects approximately 15–20% of children worldwide (Nutten, 2015). The prevalence varies widely among different countries, between rural and urban areas within a single country, and particular Asian skin types are more sensitive to urban environments (Ben-Gashir et al., 2004, Krutmann et al., 2014, Nutten, 2015, Odhiambo et al., 2009). In this study, we analyzed the genetic architecture of patients with AE from the South Asian Bangladeshi community in East London, UK using whole-exome sequencing combined with rare variant enrichment analysis.
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PublisherCopyrights
Funding Info:
Description:
The full paper is available for download at the publisher's URL here: https://doi.org/10.1016/j.jid.2018.05.013
ISSN:
0022-202X
1523-1747
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