Redefining Metal Organic Frameworks in Biosensors: Where Are We Now?

Redefining Metal Organic Frameworks in Biosensors: Where Are We Now?

ACS Applied Materials & Interfaces

10.1021/acsami.4c19307

https://doi.org/10.1021/acsami.4c19307

Melisa Wei Ning Leoi, Xin Ting Zheng, Yong Yu, Jiajia Gao, Deborah Hui Shan Ong, Clarence Zhi Han Koh, Peng Chen, Le Yang

metal organic frameworks, MOF composites, Structural engineering, nanomaterials, Enzymes, nanozymes, biosensors, Optical Sensors, electrochemical sensors

22 February 2025

Leoi, M. W. N., Zheng, X. T., Yu, Y., Gao, J., Ong, D. H. S., Koh, C. Z. H., Chen, P., & Yang, L. (2025). Redefining Metal Organic Frameworks in Biosensors: Where Are We Now? ACS Applied Materials & Interfaces, 17(9), 13246–13278. https://doi.org/10.1021/acsami.4c19307

As a broad class of porous nanomaterials, metal organic frameworks (MOFs) exhibit unique properties, such as broad tunability, high stability, atomically well-defined structure, and ordered uniform porosity. These features facilitate the rational design of MOFs as an outstanding nanomaterial candidate in biosensing, therapeutics delivery, and catalysis applications. Recently, novel modifications of the MOF nanoarchitecture and incorporation of synergistic guest materials have been investigated to achieve well-tailored functional design, gradually bridging the fundamental gap between structure and targeted activity. Specifically, the burgeoning studies of MOF-based high-performance biosensors have aimed to achieve high sensitivity, selectivity, and stability for a large variety of analytes in different sensing matrices. In this review, we elaborate the key roles of MOF nanomaterials in biosensors, including their high stability as a protective framework for biomolecules, their intrinsic sensitivity-enhancing functionalities, and their contribution of catalytic activity as a nanozyme. By examining the main structures of MOFs, we further identify varied structural engineering approaches, such as precursor tuning and guest molecule incorporation, that elucidate the concept of the structure−activity relationship of MOFs. Furthermore, we highlight the unique applications of MOF nanomaterials in electrochemical and optical biosensors for enhanced sensor performances. Finally, the challenges and future perspectives of developing next-generation MOF nanomaterials for biosensor applications are discussed.

Publisher Copyright

This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - RIE2025 Manufacturing, Trade, and Connectivity (MTC) Programmatic Fund
Grant Reference no. : M24M9b0013

This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic Funds
Grant Reference no. : A18A1b0045

This research / project is supported by the National Research Foundation - National Research Foundation Fellowship
Grant Reference no. : NRF-NRFF15-2023-0011

This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - Career Development Fund
Grant Reference no. : C233312019

This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - Central Research Fund
Grant Reference no. :

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsami.4c19307

https://oar.a-star.edu.sg/communities-collections/articles/21661

1944-8244
1944-8252

Institute of Materials Research & Engineering