Tan, S. C. L., Ning, Y., Yu, Y., Goh, W. P., Jiang, C., Liu, L., Zheng, X. T., Yang, L. (2024). Stretchable Sweat Lactate Sensor with Dual‐Signal Read‐Outs. Chemistry – An Asian Journal, 19(20). Portico. https://doi.org/10.1002/asia.202400496
Abstract:
Innovations in wearable sweat sensors hold great promise to provide deeper insights into molecular level health information non‐invasively. Lactate, a key metabolite present in sweat, holds immense significance in assessing physiological conditions and performance in sports physiology and health sensing. This paper presents the development and characterization of stretchable electrodes with ultrahigh active surface area of 648 % for lactate sensing. The as‐printed stretchable electrodes were functionalized with an electron transfer layer comprising Toluidine Blue O and multi‐walled carbon nanotubes (MWCNTs), and an enzymatic layer consisting of lactate dehydrogenase with β‐Nicotinamide adenine dinucleotide as the cofactor for lactate selectivity. This sensor achieves a dual‐signal read‐out in which both electrochemical and fluorescence signals were obtained during lactate detection, demonstrating promising sensor performance in terms of sensitivity and reliability. We demonstrate the robustness of the dual‐signal sensor under simulated conditions of physical deformation and shifted excitation. Under these compromised conditions, the performance of the stretchable electrodes remained largely unaffected, showcasing their potential for robust and adaptable sensing platforms in wearable health monitoring applications.
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Funding Info:
This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic Funds entitled Cyber Physiochemical Interfaces
Grant Reference no. : A18A1b0045
This research / project is supported by the National Research Foundation - National Research Foundation Fellowship
Grant Reference no. : NRF-NRFF15-2023-001
This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - A*STAR Career Development Fund
Grant Reference no. : C233312019
This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - RIE2025 Manufacturing, Trade, and Connectivity (MTC) Programmatic Fund entitled BLISS: Beyond Liquids with In-Situ Solid-state Surficial Sensorics
Grant Reference no. : M24M9b0013
Description:
This is the peer reviewed version of the following article: Tan, S. C. L., Ning, Y., Yu, Y., Goh, W. P., Jiang, C., Liu, L., Zheng, X. T., & Yang, L. (2024). Stretchable Sweat Lactate Sensor with Dual‐Signal Read‐Outs. Chemistry – An Asian Journal, 19(20). Portico. https://doi.org/10.1002/asia.202400496, which has been published in final form at https://doi.org/10.1002/asia.202400496. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.