PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity

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Please use this identifier to cite or link to this item: https://oar.a-star.edu.sg/communities-collections/articles/21012

Title:

PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity

Journal Title:

Theranostics

DOI:

10.7150/thno.93127

Publication URL:

http://dx.doi.org/10.7150/thno.93127

Authors:

Zu Ye, Chee Ping Ng, Haidong Liu, Qimei Bao, Shengfeng Xu, Dan Zu, Yanhua He, Yixing Huang, Abdul Qader Omer Al-aidaroos, Ke Guo, Jie Li, Lai Ping Yaw, Qiancheng Xiong, Min Thura, Weihui Zheng, Fenghui Guan, Xiangdong Cheng, Yin Shi, Qi Zeng

Keywords:

PRL1, PRL3, lipid phosphatase, macropinocytosis, cancer development

Publication Date:

29 May 2024

Citation:

Ye, Z., Ng, C. P., Liu, H., Bao, Q., Xu, S., Zu, D., He, Y., Huang, Y., Al-Aidaroos, A. Q. O., Guo, K., Li, J., Yaw, L. P., Xiong, Q., Thura, M., Zheng, W., Guan, F., Cheng, X., Shi, Y., & Zeng, Q. (2024). PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity. Theranostics, 14(9), 3423–3438. https://doi.org/10.7150/thno.93127

Abstract:

PRL1 and PRL3, members of the protein tyrosine phosphatase family, have been associated with cancer metastasis and poor prognosis. Despite extensive research on their protein phosphatase activity, their potential role as lipid phosphatases remains elusive.

License type:

Attribution 4.0 International (CC BY 4.0)

Funding Info:

This research / project is supported by the Natural Science Foundation of Zhejiang Province of China - NA
Grant Reference no. : LTGY23H160018

This research / project is supported by the Zhejiang Medical and Health Science and Technology Program - NA
Grant Reference no. : 2024KY789

This research / project is supported by the National Natural Science Foundation of China - NA
Grant Reference no. : 32370797

This research / project is supported by the Agency for Science, Technology and Research - Career Development Fund
Grant Reference no. : C210812005

This research is supported by core funding from: Institute of Molecular and Cell Biology
Grant Reference no. :

Description:

© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions

URI:

https://oar.a-star.edu.sg/communities-collections/articles/21012

ISSN:

1838-7640

Collections:

Institute of Molecular and Cell Biology

Files uploaded:

https://www.thno.org/v14p3423.pdf