Skin‐Attachable Ink‐Dispenser‐Printed Paper Fluidic Sensor Patch for Colorimetric Sweat Analysis

Skin‐Attachable Ink‐Dispenser‐Printed Paper Fluidic Sensor Patch for Colorimetric Sweat Analysis

Advanced Healthcare Materials

10.1002/adhm.202302173

http://dx.doi.org/10.1002/adhm.202302173

Xin Ting Zheng, Wei Peng Goh, Yong Yu, Laura Sutarlie, Der Ying Chen, Sherwin Chong Li Tan, Changyun Jiang, Meng Zhao, Te Ba, Hongying Li, Xiaodi Su, Le Yang

28 October 2023

Zheng, X. T., Goh, W. P., Yu, Y., Sutarlie, L., Chen, D. Y., Tan, S. C. L., Jiang, C., Zhao, M., Ba, T., Li, H., Su, X., & Yang, L. (2023). Skin‐Attachable Ink‐Dispenser‐Printed Paper Fluidic Sensor Patch for Colorimetric Sweat Analysis. Advanced Healthcare Materials, 13(3). Portico. https://doi.org/10.1002/adhm.202302173

AbstractIn situ analysis of sweat biomarkers potentially provides noninvasive lifestyle monitoring and early diagnosis. Quantitative detection of sweat rate is crucial for thermoregulation and preventing heat injuries. Here, a skin‐attachable paper fluidic patch is reported for in situ colorimetric sensing of multiple sweat markers (pH, glucose, lactate, and uric acid) with concurrent sweat rate tracking. Two sets of fluidic patterns—multiplexed detection zones and a longitudinal sweat rate channel—are directly printed by an automated ink dispenser from a specially developed ceramic‐based ink. The ceramic ink thermal‐cures into an impervious barrier, confining sweat within the channels. The ceramic‐ink‐printed boundary achieves higher pattern resolution, prevents fluid leakage, attains pattern thermal stability, and resistant to organic solvents. The cellulose matrix of the detection zones is modified with nanoparticles to improve the color homogeneity and sweat sensor sensitivity. The sweat rate channel is made moisture sensitive by incorporating a metal‐salt‐based dye. The change in saturation/color of the detection zones and/or channels upon sweat addition can be visually detected or quantified by a smartphone camera. A cost‐effective way is provided to fabricate paper fluidic sensor patches, successfully demonstrating on‐body multiplexed evaluation of sweat analytes. Such skin wearables offer on‐site analysis, meaningful to an increasingly health‐conscious population.

Publisher Copyright

This research / project is supported by the A*STAR - RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic
Grant Reference no. : A18A8b0059

This research / project is supported by the A*STAR - AME Programmatic Funds
Grant Reference no. : A18A1b0045

This research is supported by core funding from: A*STAR Central Research Fund (CRF)
Grant Reference no. : NA

This research / project is supported by the National Research Foundation - National Research Foundation Fellowship (NRFF)
Grant Reference no. : NRF-NRFF15-2023-0011

This research is supported by core funding from: A*STAR Graduate Academy studentships
Grant Reference no. : NA

This research / project is supported by the A*STAR - Career Development Fund
Grant Reference no. : C210812027

This is the peer reviewed version of the following article: Skin‐Attachable Ink‐Dispenser‐Printed Paper Fluidic Sensor Patch for Colorimetric Sweat Analysis, Zheng, X. T., Goh, W. P., Yu, Y., Sutarlie, L., Chen, D. Y., Tan, S. C. L., Jiang, C., Zhao, M., Ba, T., Li, H., Su, X., & Yang, L. (2023). Skin‐Attachable Ink‐Dispenser‐Printed Paper Fluidic Sensor Patch for Colorimetric Sweat Analysis. Advanced Healthcare Materials, 13(3). Portico. https://doi.org/10.1002/adhm.202302173, which has been published in final form at http://dx.doi.org/10.1002/adhm.202302173. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

https://oar.a-star.edu.sg/communities-collections/articles/20512

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