Sreekanth, K. V., Perumal, J., Dinish, U. S., Prabhathan, P., Liu, Y., Singh, R., Olivo, M., & Teng, J. (2023). Tunable Tamm plasmon cavity as a scalable biosensing platform for surface enhanced resonance Raman spectroscopy. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42854-7
Abstract:
AbstractSurface enhanced Resonance Raman spectroscopy (SERRS) is a powerful technique for enhancing Raman spectra by matching the laser excitation wavelength with the plasmonic resonance and the absorption peak of biomolecules. Here, we propose a tunable Tamm plasmon polariton (TPP) cavity based on a metal on distributed Bragg reflector (DBR) as a scalable sensing platform for SERRS. We develop a gold film-coated ultralow-loss phase change material (Sb2S3) based DBR, which exhibits continuously tunable TPP resonances in the optical wavelengths. We demonstrate SERRS by matching the TPP resonance with the absorption peak of the chromophore molecule at 785 nm wavelength. We use this platform to detect cardiac Troponin I protein (cTnI), a biomarker for early diagnosis of cardiovascular disease, achieving a detection limit of 380 fM. This scalable substrate shows great promise as a next-generation tunable biosensing platform for detecting disease biomarkers in body fluids for routine real-time clinical diagnosis.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - Competitive Research Programme
Grant Reference no. : NRF-CRP26-2021-0004
This research / project is supported by the A*STAR - HBMS IAF-PP
Grant Reference no. : H19H6a0025
This research / project is supported by the A*STAR - AME Individual Research Grant
Grant Reference no. : A2083c0058
This research / project is supported by the A*STAR - AME Individual Research Grant
Grant Reference no. : A20E5c0084
This research / project is supported by the A*STAR - CRF UIBR Grant
Grant Reference no. : NA
This research / project is supported by the National Research Foundation - Competitive Research Programme
Grant Reference no. : NRF-CRP23-2019- 0005