Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction

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Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction
Title:
Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction
Journal Title:
Advanced Healthcare Materials
Publication Date:
09 November 2023
Citation:
Fang, C., You, Y., Luo, F., Li, Z., Shen, Y., Wang, F., Zhang, J., Gan, R., & Ye, Y. (2023). Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction. Advanced Healthcare Materials, 13(6). Portico. https://doi.org/10.1002/adhm.202302899
Abstract:
AbstractBisphenol A (BPA) is a prevalent endocrine disruptor found in natural environments. Exposure to BPA has been associated with male infertility. The natural phytochemical icariin (ICA) has demonstrated significant promise for the treatment of male infertility. However, its effectiveness is limited due to its low bioavailability, poor water solubility, and insufficient targeting abilities. Herein, novel nanoparticles are generated from the natural silk fibroin, which are used to load ICA. The efficient drug delivery system (ICA‐SNPs) result in significantly focused drug distribution to spermatogonium, enhancing the anti‐infertility properties of ICA, and can effectively mitigate spermatogenesis dysfunction induced by BPA, control serum sex hormone levels, and enhance testicular ultrastructure. Additionally, the ICA‐SNPs restore spermatogenesis dysfunction primarily via the hormone biosynthesis, spermatogonium meiosis process, and glycerophospholipid metabolism.
License type:
Publisher Copyright
Funding Info:
This research was funded by Sichuan Natural Science Foundation [NO. 2023NSFSC1766, No. 2023NSFSC0167].
Description:
This is the peer reviewed version of the following article: Fang, C., You, Y., Luo, F., Li, Z., Shen, Y., Wang, F., Zhang, J., Gan, R., & Ye, Y. (2023). Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction. Advanced Healthcare Materials, 13(6). Portico. https://doi.org/10.1002/adhm.202302899, which has been published in final form at doi.org/10.1002/adhm.202302899. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
ISSN:
2192-2659
2192-2640
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