Zhang, R., Bi, R., Ho Jun Hui, C., Rajarahm, P., Dinish, U. S., & Olivo, M. (2021). A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies. ACS Sensors, 6(8), 2960–2966. https://
Confocal Raman spectroscopy (CRS) has shown potential in non-invasive skin analysis. However, current CRS systems have various limitations including a narrow detection band, large size, non-flexibility, slowness, and complexity, which hinder their clinical applications. Herein, we developed a portable ultrawideband CRS system with a fiber-based handheld probe to acquire the Raman spectra in both fingerprint and high wavenumber regions in a fast and quasi-simultaneous way. Dual-wavelength excitation with a dual-passband laser cleaning filter and high-speed fiber array multiplexer was adopted instead of a specialized grating and detector to achieve instant switching between the detection regions and improve system robustness. Preliminary in vivo results demonstrated its depth profiling capability in an ultrawide detection range for stratum corneum thickness, natural moisturizing factor, and water content quantification, indicating its great potential in a wide range of clinical and cosmeceutical applications.
This research / project is supported by the A*STAR - Industry Alignment Fund prepositioning program (IAF-PP)
Grant Reference no. : H19H6a0025
This research is supported by core funding from: BMRC Central Research Fund
Grant Reference no. : (UIBR) 2021