A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies

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A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies
Title:
A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies
Other Titles:
ACS Sensors
Publication Date:
11 August 2021
Citation:
Zhang, R., Bi, R., Ho Jun Hui, C., Rajarahm, P., Dinish, U. S., & Olivo, M. (2021). A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies. ACS Sensors, 6(8), 2960–2966. https:// doi.org/10.1021/acssensors.1c00761
Abstract:
Confocal Raman spectroscopy (CRS) has shown potential in non-invasive skin analysis. However, current CRS systems have various limitations including a narrow detection band, large size, non-flexibility, slowness, and complexity, which hinder their clinical applications. Herein, we developed a portable ultrawideband CRS system with a fiber-based handheld probe to acquire the Raman spectra in both fingerprint and high wavenumber regions in a fast and quasi-simultaneous way. Dual-wavelength excitation with a dual-passband laser cleaning filter and high-speed fiber array multiplexer was adopted instead of a specialized grating and detector to achieve instant switching between the detection regions and improve system robustness. Preliminary in vivo results demonstrated its depth profiling capability in an ultrawide detection range for stratum corneum thickness, natural moisturizing factor, and water content quantification, indicating its great potential in a wide range of clinical and cosmeceutical applications.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - Industry Alignment Fund prepositioning program (IAF-PP)
Grant Reference no. : H19H6a0025

This research is supported by core funding from: BMRC Central Research Fund
Grant Reference no. : (UIBR) 2021
Description:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sensors, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see doi.org/10.1021/acssensors.1c00761
ISSN:
2379-3694
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