Kuroki, A., Tay, J., Lee, G. H., & Yang, Y. Y. (2021). Broad‐Spectrum Antiviral Peptides and Polymers. Advanced Healthcare Materials, 10(23), 2101113. Portico. https://doi.org/10.1002/adhm.202101113
Abstract:
As the human cost of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still being witnessed worldwide, the development of broad-spectrum antiviral agents against emerging and re-emerging viruses is seen as a necessity to hamper the spread of infections. Various targets during the viral life-cycle can be considered to inhibit viral infection, from viral attachment to viral fusion or replication. Macromolecules represent a particularly attractive class of therapeutics due to their multivalency and versatility. Although several antiviral macromolecules hold great promise in clinical applications, the emergence of resistance after prolonged exposure urges the need for improved solutions. In the present article, the recent advancement in the discovery of antiviral peptides and polymers with diverse structural features and antiviral mechanisms is reviewed. Future perspectives, such as, the development of virucidal peptides/polymers and their coatings against SARS-CoV-2 infection, standardization of antiviral testing protocols, and use of artificial intelligence or machine learning as a tool to accelerate the discovery of antiviral macromolecules, are discussed.
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Publisher Copyright
Funding Info:
This research / project is supported by the National Medical Research Council - Clinician Scientist Award
Grant Reference no. : NMRC/CSA-INV/0024/2017
This research is supported by core funding from: Institute of Bioengineering and Bioimaging
Grant Reference no. : NA
Description:
This is the peer reviewed version of the following article: Kuroki, Tay, J., Lee, G. H., & Yang, Y. Y. (2021). Broad‐Spectrum Antiviral Peptides and Polymers. Advanced Healthcare Materials, 10(23), 2101113. Portico. https://doi.org/10.1002/adhm.202101113, which has been published in final form at http://dx.doi.org/10.1002/adhm.202101113. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions