Variant-Specific IgA Protects Against Omicron Infection

Variant-Specific IgA Protects Against Omicron Infection

The Journal of Infectious Diseases

10.1093/infdis/jiad525

https://doi.org/10.1093/infdis/jiad525

Yun Shan Goh, Siew-Wai Fong, Pei Xiang Hor, Chiew Yee Loh, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, Raphael Tze Chuen Lee, Xuan Ying Poh, Suma Rao, Po Ying Chia, Sean W X Ong, Tau Hong Lee, Clarissa Lim, Jefanie Teo, Surinder Pada, Louisa Jin Sun, Desmond Luan Seng Ong, Jyoti Somani, Eng Sing Lee, Sebastian Maurer-Stroh, Cheng-I Wang, Yee-Sin Leo, David C Lye, Barnaby Edward Young, Lisa F P Ng, Laurent Renia, , Jocelyn Jin Yu, Zheng Kuang Soh, Yi Qing Chin, Jonathan Jordon Lim, Juwinda Ongko, Eshele Anak Libau, Celine Theo, Mohammed Ridzwan Bin Abdullah, Shiau Hui Diong, He Ping Yeo, , Angeline Rouers, Chang Zi Wei, Matthew Zirui Tay, Anthony Torres-Ruesta, Nathan Wong, Yuling Huang, Alice Soh Meoy Ong, Adeline Chiew Yen Chua, Samantha Nguee, Yong Jie Tan, Vanessa Neo, Isaac Kai Jie Kam, Ajayanandan Yadunandan, Sooriya Kannan Selvam, Jarvis Goh, Ng Kah Ying, Sim Xin Yi, Wong Wei Lun, Anna Xinyi Loo, Liang Hui Loo

Covid-19, IgA, Omicrons

24 November 2023

Goh, Y. S., Fong, S.-W., Hor, P. X., Loh, C. Y., Wang, B., Salleh, S. N. M., Ngoh, E. Z. X., Lee, R. T. C., Poh, X. Y., Rao, S., Chia, P. Y., Ong, S. W. X., Lee, T. H., Lim, C., Teo, J., Pada, S., Sun, L. J., Ong, D. L. S., Somani, J., … Loo, L. H. (2023). Variant-Specific IgA Protects Against Omicron Infection. The Journal of Infectious Diseases, 230(2), e287–e291. https://doi.org/10.1093/infdis/jiad525

Abstract Background The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated. Methods We examined 2 prospective cohorts of mRNA vaccinated and boosted individuals during the Omicron wave of infection in Singapore. Results We found that individuals who remain uninfected over the follow-up period had a higher variant-specific IgA, but not IgG, antibody response at 1 month after booster vaccination, compared with individuals who became infected. Conclusions We conclude that IgA may have a potential contributory role in protection against Omicron infection. Clinical Trials Registration . NCT05142319.

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

This research / project is supported by the Biomedical Research Council Singapore A*CRUSE vaccine monitoring project; Agency for Science, Technology and Research (A*STAR) A*ccelerate GAP project - NA
Grant Reference no. : ACCL/19-GAP064-R20H-H

This research / project is supported by the National Medical Research Council Singapore COVID-19 Research Fund - NA
Grant Reference no. : COVID19RF-001, COVID19RF-007, COVID19RF-0008, COVID19RF-0018, COVID19RF-060, OFLCG19May-0034

This research / project is supported by the US Food and Drug Administration - NA
Grant Reference no. : 75F40120C00085

This research / project is supported by the A*STAR COVID-19 research - NA
Grant Reference no. : H/20/04/g1/006

This research / project is supported by the A*STAR Career Development Fund - NA
Grant Reference no. : SC35/22-805100

This research / project is supported by the Medical Research Council Singapore COVID-19 Research - NA
Grant Reference no. : COVID19RF-0018

© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com https://doi.org/10.1093/infdis/jiad525

https://oar.a-star.edu.sg/communities-collections/articles/22206

0022-1899
1537-6613

Bioinformatics Institute