Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens

Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens

Science

10.1126/science.ado5294

https://www.science.org/doi/10.1126/science.ado5294

Meera Shenoy, Diane Rico, Alina Lorant, Hamadoun Toure, Shannon Gordon, Luke Milburn, Jeanette Schwensen, Madelyn Caban, Meghan Koch

Immunology, Microbiome, Oral tolerance, Breast milk, Antibody binding

14 August 2025

Meera K. Shenoy et al. ,Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens.Science389,eado5294(2025).DOI:10.1126/science.ado5294

Publisher Copyright

M.K.S. was supported by the Fred Hutchinson Cancer Center’s Immunotherapy Integrated Research Center Award. H.T. and A.K.L. are Washington Research Foundation Postdoctoral Fellows. M.A.K. is a Pew Scholar in the Biomedical Sciences, supported by The Pew Charitable Trusts. R01A1173199 and grants from the Hartwell Foundation, Rita Allen Foundation, Fred Hutchinson Cancer Center’s Microbiome Research Initiative Integrated Research Center and the Kenneth Rainin Foundation to M.A.K. also supported this work.

Copyright © 2025 the authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original US government works. https://www.science.org/about/science-licenses-journal-article-reuse.

https://oar.a-star.edu.sg/communities-collections/articles/22122

1095-9203

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