Heng Li Chee, Yashaaswini M, Jaedeok Kim, Jing Wen Koo, Ping Luo, M. Faris H. Ramli, Jennifer L. Young, and FuKe Wang, Mechanical and Dimensional Stability of Gelatin-Based Hydrogels Through 3D Printing-Facilitated Confined Space Assembly, ACS Applied Materials Interfaces 2024 16 (44), 61105-61114. DOI: 10.1021/acsami.4c15025
Abstract:
Hydrogels have emerged as promising biomaterials for tissue regeneration; yet, their inherent swelling can cause deformation and reduced mechanical properties, posing challenges for practical applications in biomedical engineering. Traditional methods to reduce hydrogel swelling often involve complex synthesis procedures with limited flexibility. Inspired by nature’s efficient designs, we present here the approach to improve hydrogel performance using 3D printing-assisted microstructure engineering. By utilizing polymerization-induced phase separation of hydrogel from copolymerization of gelatin methacrylate and hydroxyethyl methacrylate (poly(GelMA-co-HEMA)) in the confined space during vat photopolymerization (VPP) 3D printing, we replicate the cuttlebone-like microstructure of hydrogels with enhanced mechanical properties and swelling resistance. We demonstrate here a 4-fold increase in elastic modulus compared to bulk polymerization of poly(GelMA-co-HEMA), together with improved mechanical and dimensional stability. This method offers promising opportunities for practical biomedical and tissue engineering applications, overcoming previous limitations in the design and performance.
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Funding Info:
This research / project is supported by the Agency for Science, Technology and Research - Manufacturing, Trade, and Connectivity Individual Research Grants
Grant Reference no. : M23M6c0110
This research is supported by core funding from: SERC Central Research Fund
Grant Reference no. : TIMR211001bSERCRF