Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

RSC Chemical Biology

10.1039/D3CB00149K

http://dx.doi.org/10.1039/d3cb00149k

Clare Jelinska, Srinivasaraghavan Kannan, Yuri Frosi, Siti Radhiah Ramlan, Fernaldo Winnerdy, Rajamani Lakshminarayanan, Charles W Johannes, Christopher J Brown, Anh-Tuan Phan, Daniela Rhodes, Chandra S Verma

11 October 2023

Jelinska, C., Kannan, S., Frosi, Y., Ramlan, S. R., Winnerdy, F., Lakshminarayanan, R., Johannes, C. W., Brown, C. J., Phan, A.-T., Rhodes, D., & Verma, C. S. (2023). Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein. RSC Chemical Biology, 4(12), 1096–1110. https://doi.org/10.1039/d3cb00149k

Interactions between DAXX and numerous protein interaction partners, along with the autoregulation of a DAXX SUMO Interaction Motif (SIM), can be inhibited by stapled and stitched peptides derived from a minimal DAXX binding peptide found in ATRX.

Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

This research / project is supported by NTU Lee Kong Chian School of Medicine / Singapore Ministry of Education (MOE) Academic Research Fund (AcRF) Tier 3

https://oar.a-star.edu.sg/communities-collections/articles/20706

2633-0679

Bioinformatics Institute