Wang, Y., Narasimamurthy, R., Qu, M., Shi, N., Guo, H., Xue, Y., & Barker, N. (2024). Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis. Nature Cancer, 5(4), 546–556. https://doi.org/10.1038/s43018-024-00759-4
Abstract:
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of gene expression and biochemical functions. Circadian disruption is associated with enhanced tumor formation and metastasis via dysregulation of key biological processes and modulation of cancer stem cells (CSCs) and their specialized microenvironment. Here, we review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis. Identifying circadian therapeutic targets could facilitate the development of new treatments that leverage circadian modulation to ablate tumor-resident CSCs, inhibit tumor metastasis and enhance response to current therapies.
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Funding Info:
This research / project is supported by the National Medical Research Council - Open Fund - Individual Research Grant (OF-IRG)
Grant Reference no. : OFIRG23jan-0037
Program of Shanghai Academic Research Leader
Description:
This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s43018-024-00759-4