Protein Nanotubes Assembled from Imidazole-Grafted Horseradish Peroxidase Nanogels

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Protein Nanotubes Assembled from Imidazole-Grafted Horseradish Peroxidase Nanogels
Title:
Protein Nanotubes Assembled from Imidazole-Grafted Horseradish Peroxidase Nanogels
Journal Title:
ACS Macro Letters
Publication Date:
11 July 2023
Citation:
Fan, X., Li, K., Liu, S., Wang, T., Ma, Y., Li, Z., & He, C. (2023). Protein Nanotubes Assembled from Imidazole-Grafted Horseradish Peroxidase Nanogels. ACS Macro Letters, 12(8), 1031–1036. https://doi.org/10.1021/acsmacrolett.3c00198
Abstract:
Protein assembly, a common phenomenon in nature, plays an important role in the evolution of life. Inspired by nature, assembling protein monomers into delicate nanostructures has emerged as an attractive research area. However, sophisticated protein assemblies usually need complicated designs or templates. In this work, we successfully fabricated protein nanotubes in a facile way by coordination interactions between imidazole-grafted horseradish peroxidase (HRP) nanogels (iHNs) and Cu2+. The iHNs were synthesized by polymerization on the surface of HRP by employing vinyl imidazole as a comonomer. By direct addition of Cu2+ into iHN solution, protein tubes were therefore formed. The size of the protein tubes could be adjusted by changing the added Cu2+ amount, and the mechanism behind the formation of protein nanotubes was elucidated. Furthermore, a highly sensitive H2O2 detection system was established based on the protein tubes. This work provides a facile method to construct diverse sophisticated functional protein nanomaterials.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - Science and Engineering Research Council (SERC) Central Research Fund (Use-Inspired Basic Research)
Grant Reference no. : NA
Description:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsmacrolett.3c00198.
ISSN:
2161-1653
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