A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads

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A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads
Title:
A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads
Journal Title:
ChemMedChem
Publication Date:
05 April 2022
Citation:
Chia, C. S. B. (2022). A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads. ChemMedChem, 17(11). Portico. https://doi.org/10.1002/cmdc.202200032
Abstract:
Antibody-drug conjugates (ADCs) have emerged as a promising class of biologics since the first approval of Gemtuzumab ozogamicin in 2000. Compared to small molecule drugs, ADCs are structurally much more complex as they comprise of an antibody conjugated to cytotoxic payloads by specially-designed linkers. Correspondingly, the ADC patent landscape is also much more complex. This review collates and discusses the patents protecting ADCs approved by the FDA up to 31 December 2021, with particular emphasis on their linker and cytotoxin payload technologies.
License type:
Publisher Copyright
Funding Info:
This research is supported by core funding from: Experimental Drug Development Centre
Grant Reference no. : NRF2021-IE-IECF-001
Description:
This is the peer reviewed version of the following article: Chia, C. S. B. (2022). A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads. ChemMedChem, 17(11). Portico. https://doi.org/10.1002/cmdc.202200032, which has been published in final form at doi.org/10.1002/cmdc.202200032. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
ISSN:
1860-7179
1860-7187
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