Loh JT, Teo JKH, Lim H-H and Lam K-P (2020) Emerging Roles of Downstream of Kinase 3 in Cell Signaling. Front. Immunol. 11:566192. doi: 10.3389/fimmu.2020.566192
Abstract:
Downstream of kinase (Dok) 3 is a member of the Dok family of adaptor proteins known to regulate signaling pathways downstream of various immunoreceptors. As Dok-3 lacks intrinsic catalytic activity, it functions primarily as a molecular scaffold to facilitate the nucleation of protein complexes in a regulated manner and hence, achieve specificity in directing signaling cascades. Since its discovery, considerable progress has been made toward defining the role of Dok-3 in limiting B cell-receptor signaling. Nonetheless, Dok-3 has since been implicated in the signaling of Toll-like and C-type lectin receptors. Emerging data further demonstrate that Dok-3 can act both as an activator and inhibitor, in lymphoid and non-lymphoid cell types, suggesting Dok-3 involvement in a plethora of signal transduction pathways. In this review, we will focus on the structure and expression profile of Dok-3 and highlight its role during signal transduction in B cells, innate cells as well as in bone and lung tissues.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This work is supported by the Singapore Ministry of Health’s National Medical Research Council under its Open Fund–Young Individual Research Grant (NMRC/OFYIRG/083/2018 to JTL) and Open Fund-Individual Research Grant (NMRC/OFIRG19may-0083 to K-PL, JTL, and H-HL), and an ASTAR core grant (to K-PL).
Description:
Please find the link to the article at the publisher's URL: https://doi.org/10.3389/fimmu.2020.566192