We thank F. Aguilo, M. Walsh and W.W. Tee for helpful discussions and critically reading the manuscript, H.-H. Ng (GIS/Singapore) for the kind gift of antibodies, and T. Teng and BRC Shared facilities for technical support. We acknowledge the technical expertise provided by the Advanced Molecular Pathology Laboratory (AMPL) at IMCB, and in particular we thank C.B. Ong. This work was supported by the Biomedical Research Council of A*STAR (Agency for Science, Technology and Research), Singapore. We acknowledge support from NMRC/OFIRG/0032/2017, an AGA-SINGA (Singapore Graduate Award) fellowship to S.M. and M.B., the French College of Gynecology and Obstetrics to D.H. and an NRF fellowship to D.M.M.