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25 Mar 2021 BMRC Institute of Molecular and Cell Biology Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione
17 Jul 2020 BMRC Institute of Molecular and Cell Biology Global translation during early development depends on the essential transcription factor PRDM10 Brenda Y. Han, Michelle K.Y. Seah, Imogen R. Brooks, Delia H.P. Quek, Dominic R. Huxley, Chuan-Sheng Foo, Li Ting Lee, Heike Wollmann, Huili Guo, Daniel M. Messerschmidt, Ernesto Guccione
10 Jan 2020 BMRC Institute of Molecular and Cell Biology PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly Slim Mzoughi, Federico Di Tullio, Diana H. P. Low, Corina-Mihaela Motofeanu, Sheena L. M. Ong, Heike Wollmann, Cheng Mun Wun, Paul Kruszka, Maximilian Muenke, Friedhelm Hildebrandt, N. Ray Dunn, Daniel M. Messerschmidt, Ernesto Guccione
17 Dec 2019 BMRC Institute of Molecular and Cell Biology Discovery of a chemical probe for PRDM9 Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
16 Sep 2019 BMRC Institute of Molecular and Cell Biology The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex Suneesh Kaimala, Jimsheena V. Karakkat, Sreejisha P. Sreedharan, Princy Jayaprakash, Ernest A. Adeghate, Suraiya A. Ansari, Ernesto Guccione, Eric P. K. Mensah-Brown, Bright Starling Emerald
26 Jul 2019 BMRC Institute of Molecular and Cell Biology CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I Philipp Kaldis, Nathan Palmer, S. Zakiah A. Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee, Radoslaw Sobota, Jayantha Gunaratne, Daniel M. Messerschmidt, Ernesto Guccione
10 Jul 2019 BMRC Institute of Molecular and Cell Biology The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Michelle K. Y. Seah, Yaju Wang, Pierre-Alexis Goy, Hui Mun Loh, Wen Jun Peh, Diana H. P. Low, Brenda Y. Han, Esther Wong, Ei Leen Leong, Gernot Wolf, Slim Mzoughi, Heike Wollmann, Todd S. Macfarlan, Ernesto Guccione, Daniel M. Messerschmidt
1 May 2019 BMRC Institute of Molecular and Cell Biology Epigenetic Regulation of the PTEN–AKT–RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma Akshay V. Bhat, Monica Palanichamy Kala, Vinay Kumar Rao, Luca Pignata, Huey Jin Lim, Sudha Suriyamurthy, Kenneth T. Chang, Victor K. Lee, Ernesto Guccione, Reshma Taneja
2 Apr 2019 BMRC Institute of Molecular and Cell Biology Proteomics profiling of arginine methylation defines PRMT5 substrate specificity Daniele Musiani, Jabez Bok, Enrico Massignani, Liling Wu, Tommaso Tabaglio, Marica Rosaria Ippolito, Alessandro Cuomo, Umut Ozbek, Habiba Zorgati, Umesh Ghoshdastider, Robert C. Robinson, Ernesto Guccione, Tiziana Bonaldi
7 Sep 2018 BMRC Institute of Molecular and Cell Biology MBNL1 alternative splicing isoforms play opposing roles in cancer Tommaso Tabaglio, Diana HP Low, Winnie Koon Lay Teo, Pierre Alexis Goy, Piotr Cywoniuk, Heike Wollmann, Jessica Ho, Damien Tan, Joey Aw, Andrea Pavesi, Krzysztof Sobczak, Dave Keng Boon Wee, Ernesto Guccione
19 Jul 2018 BMRC Institute of Molecular and Cell Biology PRMT5-mediated regulation of developmental myelination Patrizia Casaccia, Antonella Scaglione, Julia Patzig, Jialiang Liang, Rebecca Frawley, Jabez Bok, Angeliki Mela, Camila Yattah, Jingxian Zhang, Shun Xie Teo, Ting Zhou, Shuibing Chen, Emily Bernstein, Peter Canoll, Ernesto Guccione
9 Jul 2018 BMRC Bioinformatics Institute PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús Gil
9 Jul 2018 BMRC Institute of Molecular and Cell Biology PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús Gil
19 Dec 2017 BMRC Institute of Molecular and Cell Biology PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression Thomas L. Clarke, Jingxian Zhang, Kelly Chiang, Agnieszka E. Zielinska, Abeer M. Shaaban, Maria Pilar Sanchez-Bailon, James Jarrold, Adele Francis, Louise J. Jones, Sally Smith, Olena Barbash, Ernesto Guccione, Gillian Farnie, Matthew J. Smalley, Clare C. Davies
24 Jul 2017 BMRC Institute of Molecular and Cell Biology PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK–ERK signaling Slim Mzoughi, Jingxian Zhang, Delphine Hequet, Shun Xie Teo, Haitong Fang, Qiao Rui Xing, Marco Bezzi, Michelle Kay Yi Seah, Sheena L M Ong, Eun Myoung Shin, Heike Wollmann, Esther S M Wong, Muthafar Al-Haddawi, Colin L Stewart, Vinay Tergaonkar, Yuin-Han Loh, N Ray Dunn, Daniel M Messerschmidt, Ernesto Guccione
7 Mar 2017 BMRC Experimental Drug Development Centre Discovery and characterisation of the automethylation properties of PRDM9 Xiaoying Koh-Stenta, Anders Poulsen, Rong Li, John Liang Kuan Wee, Perlyn Zekui Kwek, Sin Yin Chew, Jianhe Peng, Liling Wu, Ernesto Guccione, Joma Joy, Jeffrey Hill
6 Nov 2015 BMRC Institute of Molecular and Cell Biology Transcription and imprinting dynamics in developing postnatal male germline stem cells Bradley R. Cairns, Jon M. Oatley, Saher Sue Hammoud, Diana H.P. Low, Chongil Yi, Chee Leng Lee, Christopher J. Payne, Douglas T. Carrell, Ernesto Guccione
29 May 2015 BMRC Institute of Medical Biology Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress. Anna V. Ivshina, Ernesto Guccione, Mei Yee Aau, Aliaksandr A. Yarmishyn, Candida Vaz, Antonis Giannakakis, Jingxian Zhang, Piroon Jenjaroenpun, Srikanth Nama, Norliyana Zainolabidin, Oleg V. Grinchuk, Mathijs Voorhoeve, Leah A. Vardy, Prabha Sampath, Vladimir A. Kuznetsov, Igor V. Kurochkin
20 Apr 2015 BMRC Institute of Molecular and Cell Biology Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity Cheryl M. Koh, Ekta Khattar, Shi Chi Leow, Chia Yi Liu, Julius Müller, Wei Xia Ang, Yinghui Li, Guido Franzoso, Shang Li, Ernesto Guccione, Vinay Tergaonkar
25 Mar 2015 BMRC Institute of Molecular and Cell Biology Trained immunity in newborn infants of HBV-infected mothers Michelle Hong, Elena Sandalova, Diana Low, Adam J. Gehring, Stefania Fieni, Barbara Amadei, Simonetta Urbani, Yap-Seng Chong, Ernesto Guccione, Antonio Bertoletti
2 Oct 2014 BMRC Institute of Molecular and Cell Biology Modeling Cerebrovascular Pathophysiology in Amyloid-β Metabolism using Neural-Crest-Derived Smooth Muscle Cells Christine Cheung, Yeek Teck Goh, Jingxian Zhang, Chenghan Wu, Ernesto Guccione
10 Sep 2014 BMRC Institute of Molecular and Cell Biology Multiplexed Analysis of Protein–Ligand Interactions by Fluorescence Anisotropy in a Microfluidic Platform Lih Feng Cheow, Ramya Viswanathan, Chee-Sing Chin, Nancy Jennifer, Robert C. Jones, Ernesto Guccione, Stephen R. Quake, William F. Burkholder
7 Aug 2014 BMRC Institute of Molecular and Cell Biology Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis Saher Sue Hammoud, Diana H.P. Low, Chongil Yi, Douglas T. Carrell, Ernesto Guccione, Bradley R. Cairns
9 Jul 2014 BMRC Institute of Molecular and Cell Biology Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis Arianna Sabò, Theresia R. Kress, Mattia Pelizzola, Stefano de Pretis, Marcin M. Gorski, Alessandra Tesi, Marco J. Morelli, Pranami Bora, Mirko Doni, Alessandro Verrecchia, Claudia Tonelli, Giovanni Fagà, Valerio Bianchi, Alberto Ronchi, Diana Low, Heiko Müller, Ernesto Guccione, Stefano Campaner, Bruno Amati
26 Jun 2014 BMRC Institute of Molecular and Cell Biology NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling Beiying Qiu, Xiaohe Shi, Ee Tsin Wong, Joy Lim, Marco Bezzi, Diana Low, Qiling Zhou, Semih Can Akıncılar, Manikandan Lakshmanan, Hannah L.F. Swa, Jill Mae Lan Tham, Jayantha Gunaratne, Kenneth K.Y. Cheng, Wanjin Hong, Karen S.L. Lam, Masahito Ikawa, Ernesto Guccione, Aimin Xu, Weiping Han, Vinay Tergaonkar
6 Mar 2014 BMRC Institute of Molecular and Cell Biology Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line Siau-Lin Loh, Cathleen Teh, Julius Müller, Ernesto Guccione, Wanjin Hong, Vladimir Korzh
31 Oct 2013 BMRC Institute of Molecular and Cell Biology Single-Cell Profiling of Epigenetic Modifiers Identifies PRDM14 as an Inducer of Cell Fate in the Mammalian Embryo Adam Burton, Julius Müller, Shengjiang Tu, Pablo Padilla-Longoria, Ernesto Guccione, Maria-Elena Torres-Padilla
26 Jul 2013 BMRC Institute of Molecular and Cell Biology Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery Sanjeeb Kumar Sahu, Leah A. Vardy, Zahid Q. Bonday, Ernesto Guccione, Marco Bezzi, Shun Xie Teo, Julius Müller, Wei Chuen Mok