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2 Feb 2023 BMRC Institute of Molecular and Cell Biology G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma Maxine S. Y. Lam, Jose Antonio Reales-Calderon, Jin Rong Ow, Joey J. Y. Aw, Damien Tan, Ragavi Vijayakumar, Erica Ceccarello, Tommaso Tabaglio, Yan Ting Lim, Wang Loo Chien, Fritz Lai, Anthony Tan Tanoto, Qingfeng Chen, Radoslaw M. Sobota, Giulia Adriani, Antonio Bertoletti, Ernesto Guccione, Andrea Pavesi Nature Communications
25 Mar 2021 BMRC Institute of Molecular and Cell Biology Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione Nucleic Acid Therapeutics
17 Jul 2020 BMRC Institute of Molecular and Cell Biology Global translation during early development depends on the essential transcription factor PRDM10 Brenda Y. Han, Michelle K.Y. Seah, Imogen R. Brooks, Delia H.P. Quek, Dominic R. Huxley, Chuan-Sheng Foo, Li Ting Lee, Heike Wollmann, Huili Guo, Daniel M. Messerschmidt, Ernesto Guccione Nature Communications
10 Jan 2020 BMRC Institute of Molecular and Cell Biology PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly Slim Mzoughi, Federico Di Tullio, Diana H. P. Low, Corina-Mihaela Motofeanu, Sheena L. M. Ong, Heike Wollmann, Cheng Mun Wun, Paul Kruszka, Maximilian Muenke, Friedhelm Hildebrandt, N. Ray Dunn, Daniel M. Messerschmidt, Ernesto Guccione Science Advances
17 Dec 2019 BMRC Institute of Molecular and Cell Biology Discovery of a chemical probe for PRDM9 Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi Nature Communications
16 Sep 2019 BMRC Institute of Molecular and Cell Biology The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex Suneesh Kaimala, Jimsheena V. Karakkat, Sreejisha P. Sreedharan, Princy Jayaprakash, Ernest A. Adeghate, Suraiya A. Ansari, Ernesto Guccione, Eric P. K. Mensah-Brown, Bright Starling Emerald Nucleic Acids Research
26 Jul 2019 BMRC Institute of Molecular and Cell Biology CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I Philipp Kaldis, Nathan Palmer, S. Zakiah A. Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee, Radoslaw Sobota, Jayantha Gunaratne, Daniel M. Messerschmidt, Ernesto Guccione Journal of Cell Biology
10 Jul 2019 BMRC Institute of Molecular and Cell Biology The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Michelle K. Y. Seah, Yaju Wang, Pierre-Alexis Goy, Hui Mun Loh, Wen Jun Peh, Diana H. P. Low, Brenda Y. Han, Esther Wong, Ei Leen Leong, Gernot Wolf, Slim Mzoughi, Heike Wollmann, Todd S. Macfarlan, Ernesto Guccione, Daniel M. Messerschmidt Development
1 May 2019 BMRC Institute of Molecular and Cell Biology Epigenetic Regulation of the PTEN–AKT–RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma Akshay V. Bhat, Monica Palanichamy Kala, Vinay Kumar Rao, Luca Pignata, Huey Jin Lim, Sudha Suriyamurthy, Kenneth T. Chang, Victor K. Lee, Ernesto Guccione, Reshma Taneja Cancer Research
2 Apr 2019 BMRC Institute of Molecular and Cell Biology Proteomics profiling of arginine methylation defines PRMT5 substrate specificity Daniele Musiani, Jabez Bok, Enrico Massignani, Liling Wu, Tommaso Tabaglio, Marica Rosaria Ippolito, Alessandro Cuomo, Umut Ozbek, Habiba Zorgati, Umesh Ghoshdastider, Robert C. Robinson, Ernesto Guccione, Tiziana Bonaldi Science Signaling