Gastrointestinal stem cells in self-renewal and cancer

Gastrointestinal stem cells in self-renewal and cancer

Journal of Gastroenterology

10.1007/s00535-011-0424-8

https://link.springer.com/article/10.1007/s00535-011-0424-8

S. Adelia Lin, Nick Barker

cancer, Intestine, Self-renewal, Stem cell, Stomach

01 September 2011

Lin SA, Barker N. Gastrointestinal stem cells in self-renewal and cancer. J Gastroenterol. 2011;46(9):1039-1055.

The gastrointestinal epithelium is a unique model for the study of mammalian stem cells. Not only does it have a highly stereotypical organization, its remarkable rate of self-renewal provides a daily readout of stem cell activity. The past decade has seen a major investment in developing technologies dedicated to revealing the identity of the long-elusive gastrointestinal stem cells. An array of purported stem cell biomarkers is now available for the mouse, including surface-expressed proteins that hold great promise as antibody targets for use in isolating human stem cells. Here we critically appraise the validity of these biomarkers and discuss their likely impact on our understanding of stem cell roles in selfrenewal and cancer in the gastrointestinal tract. © Springer 2011.

This work was supported by Agency for Science, Technology and Research (A∗STAR) Core Funding.

https://oar.a-star.edu.sg/communities-collections/articles/16347

09441174

Institute of Medical Biology