Institute of Medical Biology

Publication date Article title Author(s)
5 Feb 2020 AQP5 enriches for stem cells and cancer origins in the distal stomach Si Hui Tan, Yada Swathi, Shawna Tan, Jasmine Goh, Ryo Seishima, Kazuhiro Murakami, Masanobu Oshima, Toshikatsu Tsuji, Phyllis Phuah, Liang Thing Tan, Esther Wong, Aliya Fatehullah, Taotao Sheng, Shamaine Wei Ting Ho, Heike I. Grabsch, Supriya Srivastava, Ming Teh, Simon L. I. J. Denil, Seri Mustafah, Patrick Tan, Asim Shabbir, Jimmy So, Khay Guan Yeoh, Nick Barker
3 Sep 2019 Membrane lipid binding molecules for the isolation of bona fide extracellular vesicle types and associated biomarkers in liquid biopsy Ruenn Chai Lai, Kok Hian Tan, Sai Kiang Lim
22 Aug 2019 Circulating extracellular vesicle-associated TGFβ3 modulates response to cytotoxic therapy in head and neck squamous cell carcinoma André Luiz Vettore, Dorival Mendes-Junior Rodrigues, Soon Sim Tan, Sai Kiang Lim, Hui Sun Leong, Matias Eliseo Melendez, Cintia Regina Niederauer Ramos, Luciano de Souza Viana, Daniel S. W. Tan, André Lopes Carvalho, N. Gopalakrishna Iyer
6 Aug 2019 The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology Federica Natali, Giulia Rancati
8 Jul 2019 The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse
17 Jun 2019 Distinct localization of mature hgf from its precursor form in developing and repairing the stomach Nawaphat Jangphattananont, Hiroki Sato, Ryu Imamura, Katsuya Sakai, Yumi Terakado, Kazuhiro Murakami, Nick Barker, Hiroko Oshima, Masanobu Oshima, Junichi Takagi, Yukinari Kato, Seiji Yano, Kunio Matsumoto
28 May 2019 Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo Nick Barker, Shawn Hoon, Yuezhen Xue, Pingping He, Teena Thakur, Shifana Raja Abdeen, Priadarsini Maruthappan, Farid J. Ghadessy, David P. Lane
29 Apr 2019 Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications Kenneth W. Witwer, Bas W. M. van Balkom, Stefania Bruno, Andre Choo, Massimo Dominici, Mario Gimona, Andrew F. Hill, Dominique De Kleijn, Mickey Koh, Ruenn Chai Lai, S. Alex Mitsialis, Luis A. Ortiz, Eva Rohde, Takashi Asada, Wei Seong Toh, Daniel J. Weiss, Lei Zheng, Bernd Giebel, Sai Kiang Lim
23 Apr 2019 A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma Dorival Mendes Rodrigues-Junior, Soon Sim Tan, Luciano de Souza Viana, André Lopes Carvalho, Sai Kiang Lim, N Gopalakrishna Iyer, André Luiz Vettore
30 Jan 2019 One rogue agent suffices for genomic chaos Katherine E. Larrimore, Giulia Rancati
8 Jan 2019 Frizzled-7 is required for Wnt signaling in gastric tumors with and without APC mutations Dustin J. Flanagan, Nick Barker, Natasha S. Di Costanzo, Elizabeth A. Mason, Austin Gurney, Valerie S. Meniel, Sarah Koushyar, Chloe R. Austin, Matthias Ernst, Helen B. Pearson, Alex Boussioutas, Hans Clevers, Toby J. Phesse, Elizabeth Vincan
31 Dec 2018 Environmental stresses induce karyotypic instability in colorectal cancer cells Norman Pavelka, Daniela Cimini, Giulia Rancati, Zhihao Tan, Yong Jie Andrew Chan, Ying Jie Karen Chua, Samuel D. Rutledge
31 Dec 2018 Environmental stresses induce karyotypic instability in colorectal cancer cells Zhihao Tan, Yong Jie Andrew Chan, Ying Jie Karen Chua, Samuel D. Rutledge, Norman Pavelka, Daniela Cimini, Giulia Rancati
11 Sep 2018 Differential Expression of Keratinocyte-Derived Extracellular Membrane Vesicle MiRNAs Discriminates Exosomes from Apoptotic Bodies and Microvesicles. Uyen T.T. Than, Dominic Guanzon, James A. Broadbent, David Leavesley, Carlos Salomon, Tony J. Parker
3 Apr 2018 Cancer: a CINful evolution Altea Targa, Giulia Rancati
1 Mar 2018 Xanthine Oxidoreductase – A novel therapeutic target for the treatment of chronic wounds. Melissa Laura Fernandez, Dario Stupar, Tristan Croll, David Leavesley, Zee Upton
21 Feb 2018 Recent Advances in Lgr5+ Stem Cell Research Carly Leung, Si Hui Tan, Nick Barker
13 Feb 2018 Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis Zhihao Tan, De Zhi Valerie Chu, Yong Jie Andrew Chan, Yi Ena Lu, Giulia Rancati
9 Jan 2018 C/EBPβ Mediates RNA Polymerase III-driven Transcription of oncomiR-138 in Malignant Gliomas Federica Di Pascale, Srikanath Nama, Manish Muhuri, Shan Quah, Hisyam M Ismail, Xin Hui Derryn Chan, Gopinath M Sundaram, Rajkumar Ramalingam, Brian Burke, Prabha Sampath
8 Jan 2018 Chapter Two - Wnt Signaling in Adult Epithelial Stem Cells and Cancer Si Hui Tan, Nick Barker
13 Dec 2017 Extracellular vesicles yield predictive pre-eclampsia biomarkers Kok Hian Tan, Soon Sim Tan, Mor Jack Ng, Wan Shi Tay, Wei Kian Sim, John Carson Allen, Sai Kiang Lim
2 Aug 2017 Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo Dustin J. Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J. Phesse, Elizabeth Vincan
5 Jun 2017 Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach Marc Leushacke, Si Hui Tan, Angeline Wong, Yada Swathi, Amin Hajamohideen, Liang Thing Tan, Jasmine Goh, Esther Wong, Simon L. I. J. Denil, Kazuhiro Murakami, Nick Barker
1 May 2017 Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing. Tony J. Parker, Uyen T.T. Than, Dominic Guanzon, David Leavesley
17 Feb 2017 A fence barrier method of leading edge cell capture for explorative biochemical research Lucas J. Wager, Rachael Z. Murray, Erik W. Thompson, David Leavesley
5 Dec 2016 The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis Floriane Meuris, Laetitia Carthagena, Agnieszka Jaracz-Ros, Françoise Gaudin, Pasquale Cutolo, Claire Deback, Yuezhen Xue, Françoise Thierry, John Doorbar, Françoise Bachelerie
26 Feb 2016 Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium Marc Leushacke, Nick Barker, Carmen Pin
25 Feb 2016 Organoids as an in vitro model of human development and disease Aliya Fatehullah, Si Hui Tan, Nick Barker
22 Feb 2016 Adaptive Evolution: Don't Fix What's Broken Gaowen Liu, Giulia Rancati
31 Dec 2015 Applying extracellular vesicles based therapeutics in clinical trials Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit Buzas, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A. Court, Hernando A. del Portillo, Lorraine O’Driscoll, Stefano Fais, Juan M. Falcón-Pérez, Ursula Felderhoff-Mueser, Lorenzo Fraile, Yong Song Gho, André Görgens, Ramesh C. Gupta, An Hendrix, Dirk M. Hermann, Andrew F. Hill, Fred Hochberg, Peter A. Horn, Dominique De Kleijn, Lambros Kordelas, Boris W. Kramer, Eva-Maria Krämer-Albers, Sandra Laner-Plamberger, Saara Laitinen, Tommaso Leonardi, Magdalena J. Lorenowicz, Sai Kiang Lim, Jan Lötvall, Casey A. Maguire, Antonio Marcilla, Irina Nazarenko, Takahiro Ochiya, Tushar Patel, Shona Pedersen, Gabriella Pocsfalvi, Stefano Pluchino, Peter Quesenberry, Ilona G. Reischl, Francisco J. Rivera, Ralf Sanzenbacher, Katharina Schallmoser, Ineke Slaper-Cortenbach, Dirk Strunk, Torsten Tonn, Pieter Vader, Bas W. M. van Balkom, Marca Wauben, Samir El Andaloussi, Coltilde Thery, Eva Rohde, Bernd Giebel
25 Nov 2015 Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability Gaowen Liu, Mei Yun Jacy Yong, Marina Yurieva, Kandhadayar Gopalan Srinivasan, Jaron Liu, John Soon Yew Lim, Michael Poidinger, Graham Daniel Wright, Francesca Zolezzi, Hyungwon Choi, Norman Pavelka, Giulia Rancati
17 Sep 2015 ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway Lena Ho, Shawn Y.X. Tan, Sheena Wee, Yixuan Wu, Sam J.C. Tan, Navin B. Ramakrishna, Serene C. Chng, Srikanth Nama, Iwona Szczerbinska, Yun-Shen Chan, Stuart Avery, Norihiro Tsuneyoshi, Huck Hui Ng, Jayantha Gunaratne, N. Ray Dunn, Bruno Reversade
9 Sep 2015 Ovary and fimbrial stem cells: biology, niche and cancer origins Annie Ng, Nick Barker
14 Aug 2015 Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro Gopu Sriram, Paul Lorenz Bigliardi, Mei Bigliardi-Qi
6 Aug 2015 An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Rachel Sennett, Zichen Wang, Ame´ lie Rezza, Laura Grisanti, Nataly Roitershtein, Cristina Sicchio, Ka Wai Mok, Nicholas J. Heitman, Carlos Clavel, Avi Ma’ayan, Michael Rendl
3 Aug 2015 E-cadherin can limit the transforming properties of activating β-catenin mutations Sujata Biswas, Simon Leedham, David J. Huels, Rachel A Ridgway, Sorina Radulescu, Marc Leushacke, Andrew D. Campbell, Stefano Serra, Runjan Chetty, Guenievre Moreauz, Lee Parry, James Matthews, Fei Song, Ann Hedley, Gabriela Kalna, Fatih Ceteci, Karen R. Reed, Valerie S. Meniel, Aoife Maguire, Brendan Doyle, Ola Söderberg, Nick Barker, Alastair Watson, Lionel Larue, Alan R. Clarke, Owen J. Sansom
22 Jul 2015 Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice Amanda M. Goh, Yuezhen Xue, Marc Leushacke, Ling Li, Julin S. Wong, Poh Cheang Chiam, Siti Aishah Rahmat, Michael B. Mann, Karen M. Mann, Nick Barker, Guillermina Lozano, Tamara Terzian, David P. Lane
21 Jul 2015 Directional bleb formation in spherical cells under temperature gradient. Takeshi Itabashi, Takashi Ohki, Madoka Suzuki, Shin'ichi Ishiwata, Kotaro Oyama, Tomomi Arai, Akira Isaka, Taku Sekiguchi, Hideki Itoh, Yusuke Seto, Makito Miyazaki
14 Jul 2015 Transcriptional control of late differentiation in human keratinocytes by TAp63 and Notch Li Fang Koh, Boon Kiat Ng, Juliette Bertrand, Françoise Thierry
29 May 2015 Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress. Anna V. Ivshina, Ernesto Guccione, Mei Yee Aau, Aliaksandr A. Yarmishyn, Candida Vaz, Antonis Giannakakis, Jingxian Zhang, Piroon Jenjaroenpun, Srikanth Nama, Norliyana Zainolabidin, Oleg V. Grinchuk, Mathijs Voorhoeve, Leah A. Vardy, Prabha Sampath, Vladimir A. Kuznetsov, Igor V. Kurochkin
20 May 2015 Aneuploidy and chromosomal instability in cancer: a jackpot to chaos Maybelline Giam, Giulia Rancati
2 Apr 2015 PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells Christopher V.E. Wright, Norris Ray Dunn, Adrian Kee Keong Teo, Norihiro Tsuneyoshi, Shawn Hoon, Ee Kim Tan, Lawrence W. Stanton
24 Mar 2015 Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis Alvin Wen Choong Chua, Ennan Yang, Peiyun Teo, Yixin Ting, Colin Song, Dongrui Ma, Ellen Birgitte Lane, Seng Teik Lee
10 Mar 2015 Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, Helen E Abud
9 Mar 2015 Mesenchymal Stem Cell Exosomes Ruenn Chai Lai, Ronne Wee Yeh Yeo, Sai Kiang Lim
1 Feb 2015 The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3 Mei Bigliardi-Qi, Christian Widmann, Paul L. Bigliardi, Christine Neumann
1 Jan 2015 Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration P. L. Bigliardi, C. Neumann, Y. L. Teo, A. Pant, M Bigliardi-Qi
19 Dec 2014 A unique role for p53 in the regulation of M2 macrophage polarization L Li, DSW Ng, W-C Mah, FF Almeida, SA Rahmat, VK Rao, SC Leow, F Laudisi, MT Peh, AM Goh, JSY Lim, GD Wright, A Mortellaro, R Taneja, F Ginhoux, CG Lee, PK Moore, DP Lane
17 Dec 2014 Katanin p80 regulates human cortical development by limiting centriole and cilia number Mohammed Al-Dosari, Anas Alazami, Mohammed Alowain, Fowzan S. Alkuraya, Jeremy F. Reiter, Matthew P. Harris, Bruno Reversade, Christopher A. Walsh, Wen F. Hu, Oz Pomp, Tawfeg Ben-Omran, Andrew Kodani, Katrin Henke, Ganeshwaran H. Mochida, Timothy W. Yu, Mollie B. Woodworth, Carine Bonnard, Grace Selva Raj, Thong Teck Tan, Hanan Hamamy, Amira Masri, Mohammad Shboul, Muna Al Saffar, Jennifer N. Partlow
22 Oct 2014 Immunotherapeutic potential of extracellular vesicles Bin Zhang, Yijun Yin, Ruenn Chai Lai, Sai Kiang Lim