Fatehullah, A., Tan, S. & Barker, N. Organoids as an in vitro model of human development and disease. Nat Cell Biol 18, 246–254 (2016).
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.
This work was supported by Agency for Science, Technology and Research (A*STAR). Core Funding