Arfan, G., Ong, C. Y. F., Ng, S. M. S., Lau, Q. Y., Ng, F. M., Ong, E. H. Q., Hill, J., & Chia, C. S. B. (2018). Designing an ultra‐short antibacterial peptide with potent activity against Mupirocin‐resistant MRSA. Chemical Biology & Drug Design, 93(1), 4–11. Portico. https://doi.org/10.1111/cbdd.13377
Abstract:
AbstractStaphylococcus aureus is the pathogen responsible for the majority of human skin infections. In particular, the methicillin‐resistant variety, MRSA, has become a global clinical concern. The extensive use of mupirocin, the first‐line topical antibacterial drug of choice, has led to the emergence of mupirocin‐resistant MRSA globally, resulting in the urgent need for a replacement. Antimicrobial peptides are deemed plausible candidates. Herein, we describe a structure–activity relationship approach in the design of an ultra‐short peptide with potent anti‐MRSA activity with a rapid, bactericidal mode of action. Coupled to a low cytotoxic activity, we believe our lead compound can be developed into a topical antibacterial agent to replace mupirocin as the first‐line drug for treating MRSA skin infections.
License type:
Publisher Copyright
Funding Info:
Agency for Science, Technology and Research (A*STAR) Biomedical Research Council
Description:
This is the peer reviewed version of the following article: Arfan G, Ong CYF, Ng SMS, et al. Designing an ultra‐short antibacterial peptide with potent activity against Mupirocin‐resistant MRSA. Chem Biol Drug Des. 2018;00:1–8. https://doi.org/10.1111/cbdd.13377, which has been published in final form at https://doi.org/10.1111/cbdd.13377. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.