Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA.

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Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA.
Title:
Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA.
Other Titles:
Chemical Biology & Drug Design
Publication Date:
13 August 2018
Citation:
Arfan G, Ong CYF, Ng SMS, et al. Designing an ultra‐short antibacterial peptide with potent activity against Mupirocin‐resistant MRSA. Chem Biol Drug Des. 2018;00:1–8. https://doi.org/10.1111/cbdd.13377
Abstract:
Staphylococcus aureus is the pathogen responsible for the majority of human skin infections. In particular, the Meticillin-resistant variety, MRSA, has become a global clinical concern. The extensive use of Mupirocin, the first-line topical antibacterial drug of choice, has led to the emergence of Mupirocin-resistant MRSA globally, resulting in the urgent need for a replacement. Antimicrobial peptides are deemed plausible candidates. Herein, we describe a structure-activity relationship approach in the design of an ultra-short peptide with potent anti-MRSA activity with a rapid, bactericidal mode of action. Coupled to a low cytotoxic activity, we believe our lead compound can be developed into a topical antibacterial agent to replace Mupirocin as the first-line drug for treating MRSA skin infections.
License type:
PublisherCopyrights
Funding Info:
Agency for Science, Technology and Research (A*STAR) Biomedical Research Council
Description:
This is the peer reviewed version of the following article: Arfan G, Ong CYF, Ng SMS, et al. Designing an ultra‐short antibacterial peptide with potent activity against Mupirocin‐resistant MRSA. Chem Biol Drug Des. 2018;00:1–8. https://doi.org/10.1111/cbdd.13377, which has been published in final form at https://doi.org/10.1111/cbdd.13377. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
ISSN:
1747-0277
1747-0285
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