The use of porcupine inhibitors to target Wnt-driven cancers

The use of porcupine inhibitors to target Wnt-driven cancers
Title:
The use of porcupine inhibitors to target Wnt-driven cancers
Other Titles:
Bioorganic & Medicinal Chemistry Letters
Publication Date:
23 October 2015
Citation:
Abstract:
Over the past decade, academic groups and pharmaceutical companies have uncovered several components and targets for intervention in the Wnt pathway. One approach is to block Wnt signalling through the use of orally bioavailable small molecules that prevent Wnt ligand secretion. In recent years, the membrane bound O-acyl transferase (MBOAT) porcupine (PORCN) has emerged as a molecular target of interest in the search for clinical options to treat Wnt-driven cancers. This review shall provide an overview of the reported small molecule inhibitors for PORCN and discuss the progress made in identifying human disease models that are responsive to PORCN inhibitors.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
ASTAR BMRC
Description:
Full paper can be downloaded from the Publisher's URL provided.
ISSN:
0960-894X
Files uploaded:

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