Lan, H., Tan, X. H. M., Le, M.-T. T., Chien, H.-Y., Zheng, R., Rowat, A. C., Teitell, M. A., & Chiou, P.-Y. (2024). Optomagnetic Micromirror Arrays for Mapping Large Area Stiffness Distributions of Biomimetic Materials. Small, 21(1). Portico. https://doi.org/10.1002/smll.202406389
Abstract:
Abstract
A new device termed “Optomagnetic Micromirror Arrays” (OMA) is demonstrated capable of mapping the stiffness distribution of biomimetic materials across a 5.1 mm × 7.2 mm field of view with cellular resolution. The OMA device comprises an array of 50 000 magnetic micromirrors with optical grating structures embedded beneath an elastic PDMS film, with biomimetic materials affixed on top. Illumination of a broadband white light beam onto these micromirrors results in the reflection of microscale rainbow light rays on each micromirror. When a magnetic field is applied, it causes each micromirror to tilt differently depending on the local stiffness of the biomimetic materials. Through imaging these micromirrors with low N.A. optics, a specific narrow band of reflection light rays from each micromirror is captured. Changing a micromirror's tilt angle also alters the color spectrum it reflects back to the imaging system and the color of the micromirror image it represents. As a result, OMA can infer the local stiffness of the biomimetic materials through the color change detected on each micromirror. OMA offers the potential for high‐throughput stiffness mapping at the tissue‐level while maintaining spatial resolution at the cellular level.
License type:
Publisher Copyright
Funding Info:
This research is supported by the USA: National Institutes of Health (NIH) R01GM127985, and NSF CMMI 2029454, NSF DBI 2345571 and a NSF BRITE Fellow Award to ACR (CMMI-2135747).
Reference
Description:
This is the peer reviewed version of the following article: Lan, H., Tan, X. H. M., Le, M.-T. T., Chien, H.-Y., Zheng, R., Rowat, A. C., Teitell, M. A., & Chiou, P.-Y. (2024). Optomagnetic Micromirror Arrays for Mapping Large Area Stiffness Distributions of Biomimetic Materials. Small, 21(1). Portico. https://doi.org/10.1002/smll.202406389
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