Li, Y., Loh, Y. R., Li, Q., Luo, D., & Kang, C. (2024). 1H, 15N and 13C backbone resonance assignment of the N-terminal region of Zika virus NS4B protein in detergent micelles. Biomolecular NMR Assignments, 19(1), 1–6. https://doi.org/10.1007/s12104-024-10208-z
Abstract:
Zika virus has raised global concerns due to its link to microcephaly and Guillain–Barré syndrome in adults. One of viral nonstructural proteins-NS4B, an integral membrane protein, plays crucial roles in viral replication by interacting with both viral and host proteins, rendering it an attractive drug target for antiviral development. We purified the N-terminal region of ZIKV NS4B (NS4B NTD) and reconstituted it into detergent micelles. Here, we report the assignments of the backbone resonances of NS4B NTD in detergent micelles. The available assignment is useful for understanding its structure and ligand binding to provide useful information for developing NS4B inhibitors.
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Publisher Copyright
Funding Info:
This research is supported by core funding from: Experimental Drug Development Centre
Grant Reference no. : NA
Description:
This is a post-peer-review, pre-copyedit version of an article published in Biomolecular NMR Assignments. The final authenticated version is available online at: http://dx.doi.org/https://doi.org/10.1007/s12104-024-10208-z.