Liu, M., Zhu, B., & Li, Q.-J. (2024). IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled. Cancer Cell, 42(11), 1820–1822. https://doi.org/10.1016/j.ccell.2024.09.015
Abstract:
In a Science paper, Park et al. identified interleukin (IL)-1a as a key driver of positive feedback in inflammaging, linking aging-associated downregulationofDNMT3AtoincreasedIL-1aproductioninlungmyeloidcells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice.
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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - NRF Investigatorship
Grant Reference no. : NRF-NRFI09-0016
This research is supported by core funding from: Biomedical Research Council
Grant Reference no. :