Paul, S. S., Patwa, S. M., Tan, Y. (2023). Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applications. Journal of Viral Hepatitis, 30(11), 870–878. Portico. https://doi.org/10.1111/jvh.13880
Abstract:
Over 250 million people are living with chronic infection caused by the hepatitis B virus (HBV). HBV has three surface proteins, namely small (SHBs), medium (MHBs) and large (LHBs), and they play different roles in the virus life cycle. The approved hepatitis B vaccine only contains the SHBs protein and many studies have focused on characterising the functional domains in SHBs. Although the LHBs protein is less studied, recent studies have shown that it plays important roles in mediating viral entry, replication and assembly. Over the years, there have been major advancements in monoclonal antibody (mAb) discovery tools and multiple mAbs have been developed to specifically target the preS1 domain in LHBs. We summarise the HBV infection systems and antibody discovery strategies that have been utilised by various research groups to assess the potential use of anti‐preS1 mAbs as therapeutic antibodies against HBV or in the development of new diagnostic assays.
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Funding Info:
This research / project is supported by the Agency for Science, Technology and Research - GAP fund
Grant Reference no. : I22D1AG008
This research / project is supported by the Agency for Science, Technology and Research - Singapore International Graduate Award (SINGA)
Grant Reference no. :
Description:
This is the peer reviewed version of the following article: Paul, S. S., Patwa, S. M., & Tan, Y. (2023). Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applications. Journal of Viral Hepatitis, 30(11), 870–878. Portico. https://doi.org/10.1111/jvh.13880, which has been published in final form at https://doi.org/10.1111/jvh.13880. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.