Aiderus, A., Barker, N., Tergaonkar, V. (2024). Serrated colorectal cancer: preclinical models and molecular pathways. Trends in Cancer, 10(1), 76–91. https://doi.org/10.1016/j.trecan.2023.09.011
Abstract:
Serrated lesions are histologically heterogeneous, and detection can be challenging
as these lesions have subtle features that may be missed by endoscopy. Furthermore, while approximately 30% of colorectal cancers (CRCs) arise from serrated
lesions, only 8–10% of invasive serrated CRCs exhibit serrated morphology at presentation, suggesting potential loss of apparent characteristics with increased
malignancy. Thus, understanding the genetic basis driving serrated CRC initiation
and progression is critical to improve diagnosis and identify therapeutic biomarkers
and targets to guide disease management. This review discusses the preclinical
models of serrated CRCs reported to date and how these systems have been
used to provide mechanistic insights into tumor initiation, progression, and novel
treatment targets.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the Agency for Science, Technology and Research - BMRC Central Research Fund - User Inspired Basic Research (UIBR) award
Grant Reference no. :
This research / project is supported by the National Research Foundation (NRF) - Competitive Research Programme
Grant Reference no. : NRF-CRP26-2021-0001
This research / project is supported by the National Medical Research Council (NMRC) - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG21jun-0101
This research / project is supported by the National Medical Research Council (NMRC) - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG19may-0069