Li, Q., & Kang, C. (2023). Targeting RNA‐binding proteins with small molecules: Perspectives, pitfalls and bifunctional molecules. FEBS Letters, 597(16), 2031–2047. Portico. https://doi.org/10.1002/1873-3468.14710
Abstract:
RNA‐binding proteins (RBPs) play vital roles in organisms through binding with RNAs to regulate their functions. Small molecules affecting the function of RBPs have been developed, providing new avenues for drug discovery. Herein, we describe the perspectives on developing small molecule regulators of RBPs. The following types of small molecule modulators are of great interest in drug discovery: small molecules binding to RBPs to affect interactions with RNA molecules, bifunctional molecules binding to RNA or RBP to influence their interactions, and other types of molecules that affect the stability of RNA or RBPs. Moreover, we emphasize that the bifunctional molecules may play important roles in small molecule development to overcome the challenges encountered in the process of drug discovery.
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Publisher Copyright
Funding Info:
This research / project is supported by the National Medical Research Council - Open Fund Individual Research Grant
Grant Reference no. : MOH-000378-00
Description:
This is the peer reviewed version of the following article: Li, Q., & Kang, C. (2023). Targeting RNA‐binding proteins with small molecules: Perspectives, pitfalls and bifunctional molecules. FEBS Letters, 597(16), 2031–2047. Portico. https://doi.org/10.1002/1873-3468.14710
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